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Fanconi's anemia treated by allogeneic marrow transplantation.

Publication ,  Journal Article
Deeg, HJ; Storb, R; Thomas, ED; Appelbaum, F; Buckner, CD; Clift, RA; Doney, K; Johnson, L; Sanders, JE; Stewart, P; Sullivan, KM; Witherspoon, RP
Published in: Blood
May 1983

Eight patients with Fanconi's anemia were given cyclophosphamide alone (seven patients) or combined with procarbazine and antithymocyte globulin (one patient) followed by marrow grafts from HLA-identical siblings. All patients had engraftment. Seven developed acute and three chronic graft-versus-host disease (GVHD). Three patients died with GVHD and infectious complications (days 19, 56, and 82) and one with an intracerebral hemorrhage (day 540). Four patients are surviving 647-3435 days after grafting, two are well, and two have chronic GVHD that is improving. These results show that Fanconi's anemia can be treated successfully by allogeneic marrow transplantation.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

May 1983

Volume

61

Issue

5

Start / End Page

954 / 959

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Male
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Female
  • Fanconi Anemia
  • Child, Preschool
  • Child
  • Bone Marrow Transplantation
 

Citation

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Chicago
ICMJE
MLA
NLM
Deeg, H. J., Storb, R., Thomas, E. D., Appelbaum, F., Buckner, C. D., Clift, R. A., … Witherspoon, R. P. (1983). Fanconi's anemia treated by allogeneic marrow transplantation. Blood, 61(5), 954–959.
Deeg, H. J., R. Storb, E. D. Thomas, F. Appelbaum, C. D. Buckner, R. A. Clift, K. Doney, et al. “Fanconi's anemia treated by allogeneic marrow transplantation.Blood 61, no. 5 (May 1983): 954–59.
Deeg HJ, Storb R, Thomas ED, Appelbaum F, Buckner CD, Clift RA, et al. Fanconi's anemia treated by allogeneic marrow transplantation. Blood. 1983 May;61(5):954–9.
Deeg, H. J., et al. “Fanconi's anemia treated by allogeneic marrow transplantation.Blood, vol. 61, no. 5, May 1983, pp. 954–59.
Deeg HJ, Storb R, Thomas ED, Appelbaum F, Buckner CD, Clift RA, Doney K, Johnson L, Sanders JE, Stewart P, Sullivan KM, Witherspoon RP. Fanconi's anemia treated by allogeneic marrow transplantation. Blood. 1983 May;61(5):954–959.

Published In

Blood

ISSN

0006-4971

Publication Date

May 1983

Volume

61

Issue

5

Start / End Page

954 / 959

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Male
  • Immunology
  • Humans
  • Graft vs Host Reaction
  • Female
  • Fanconi Anemia
  • Child, Preschool
  • Child
  • Bone Marrow Transplantation