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Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics

Publication ,  Journal Article
Vo-Dinh, T; Wang, HN
Published in: Proceedings of SPIE - The International Society for Optical Engineering
December 1, 2012

This lecture presents an overview of recent advances in the development of optical nanobiosensor and nanoprobe technology at the nexus of engineering, biology, medicine and nanotechnology. The presentation describes two areas of research related to the development of nanoprobes and nanosensors for biomolecule detection and single-cell analysis : (1) plasmonics nanoprobes using surface-enhanced Raman scattering (SERS) detection; and (2) nanobiosensors for in vivo analysis of a single cell for molecular diagnostics and imaging, and ultra-high throughput screening. Novel nanobiosensors and nanoprobes combining bio-recognition and nanotechnology have been developed for in-vitro molecular diagnostics and in-vivo monitoring of biological targets and biochemical processes in a single living cell. These studies demonstrate applications of plasmonics molecular sentinel nanoprobes for diagnostics of diseases such as cancer and the use of nano-biosensors for measurements of molecular signaling pathways inside a single cell. Fiberoptics-based nanobiosensors are used to detect apoptotic processes in single cells following photodynamic cancer treatment or to monitor pH in cancer cells. These nanodevices open new possibilities to a wide range of applications in medical diagnostics at the point of care, global health, molecular imaging, biology research, ultra-high throughput screening, and investigations of the therapeutic action of pharmaceutical agents. © 2012 SPIE.

Duke Scholars

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 2012

Volume

8421

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

Citation

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Vo-Dinh, T., & Wang, H. N. (2012). Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering, 8421. https://doi.org/10.1117/12.2007658
Vo-Dinh, T., and H. N. Wang. “Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics.” Proceedings of SPIE - The International Society for Optical Engineering 8421 (December 1, 2012). https://doi.org/10.1117/12.2007658.
Vo-Dinh T, Wang HN. Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering. 2012 Dec 1;8421.
Vo-Dinh, T., and H. N. Wang. “Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics.” Proceedings of SPIE - The International Society for Optical Engineering, vol. 8421, Dec. 2012. Scopus, doi:10.1117/12.2007658.
Vo-Dinh T, Wang HN. Optical nanosensors and nanoprobes: From single-cell exploration to medical diagnostics. Proceedings of SPIE - The International Society for Optical Engineering. 2012 Dec 1;8421.

Published In

Proceedings of SPIE - The International Society for Optical Engineering

DOI

ISSN

0277-786X

Publication Date

December 1, 2012

Volume

8421

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering