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mir-17-92: a polycistronic oncomir with pleiotropic functions.

Publication ,  Journal Article
Olive, V; Li, Q; He, L
Published in: Immunol Rev
May 2013

Neoplastic transformation is caused by accumulation of genetic lesions that ultimately convert normal cells into tumor cells with uncontrolled proliferation and survival, unlimited replicative potential, and invasive growth. Emerging evidence has highlighted the functional importance of non-coding RNAs, particularly microRNAs (miRNAs), in the initiation and progression of tumor development. The mir-17-92 miRNA is among the best characterized miRNA oncogenes, whose genomic amplification or aberrant elevation are frequently observed in a variety of tumor types. Unlike protein-coding oncogenes, where one transcript produces one protein, mir-17-92 encodes a polycistronic miRNA transcript that yields six individual miRNA components. This unique gene structure, shared by many important miRNA oncogenes and tumor suppressors, underlies the unique functionality of mir-17-92 in a cell type and context-dependent manner. Recent functional dissection of mir-17-92 indicates that individual mir-17-92 components perform distinct biological functions, which collectively regulate multiple related cellular processes during development and disease. The structural complexity of mir-17-92 as a polycistronic miRNA oncogene, along with the complex mode of interactions among its components, constitutes the molecular basis for its unique functional complexity during normal and tumor development.

Duke Scholars

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

May 2013

Volume

253

Issue

1

Start / End Page

158 / 166

Location

England

Related Subject Headings

  • Structure-Activity Relationship
  • RNA, Long Noncoding
  • Organ Specificity
  • Oncogenes
  • Neoplasms
  • MicroRNAs
  • Immunology
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Cellular Microenvironment
 

Citation

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ICMJE
MLA
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Olive, V., Li, Q., & He, L. (2013). mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev, 253(1), 158–166. https://doi.org/10.1111/imr.12054
Olive, Virginie, Qijing Li, and Lin He. “mir-17-92: a polycistronic oncomir with pleiotropic functions.Immunol Rev 253, no. 1 (May 2013): 158–66. https://doi.org/10.1111/imr.12054.
Olive V, Li Q, He L. mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev. 2013 May;253(1):158–66.
Olive, Virginie, et al. “mir-17-92: a polycistronic oncomir with pleiotropic functions.Immunol Rev, vol. 253, no. 1, May 2013, pp. 158–66. Pubmed, doi:10.1111/imr.12054.
Olive V, Li Q, He L. mir-17-92: a polycistronic oncomir with pleiotropic functions. Immunol Rev. 2013 May;253(1):158–166.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

May 2013

Volume

253

Issue

1

Start / End Page

158 / 166

Location

England

Related Subject Headings

  • Structure-Activity Relationship
  • RNA, Long Noncoding
  • Organ Specificity
  • Oncogenes
  • Neoplasms
  • MicroRNAs
  • Immunology
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Cellular Microenvironment