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Concepts of blood transfusion in adults.

Publication ,  Other
Goodnough, LT; Levy, JH; Murphy, MF
Published in: Lancet
May 25, 2013

Recent progress has been made in the identification and implementation of best transfusion practices on the basis of evidence-based clinical trials, published clinical practice guidelines, and process improvements for blood use and clinical patient outcomes. However, substantial variability persists in transfusion outcomes for patients in some clinical settings--eg, patients undergoing cardiothoracic surgery. This variability could be the result of insufficient understanding of published guidelines; different recommendations of medical societies, including the specification of a haemoglobin concentration threshold to use as a transfusion trigger; the value of haemoglobin as a surrogate indicator for transfusion benefit, even though only changes in concentration and not absolute red cell mass of haemoglobin can be identified; and disagreement about the validity of the level 1 evidence for clinical practice guidelines. Nevertheless, institutional experience and national databases suggest that a restrictive blood transfusion approach is being increasingly implemented as best practice.

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Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

May 25, 2013

Volume

381

Issue

9880

Start / End Page

1845 / 1854

Location

England

Related Subject Headings

  • Transfusion Reaction
  • Randomized Controlled Trials as Topic
  • Professional Practice
  • Practice Guidelines as Topic
  • Postoperative Complications
  • Humans
  • Hemoglobins
  • Guideline Adherence
  • General & Internal Medicine
  • Evidence-Based Medicine
 

Citation

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Goodnough, L. T., Levy, J. H., & Murphy, M. F. (2013). Concepts of blood transfusion in adults. Lancet. England. https://doi.org/10.1016/S0140-6736(13)60650-9
Goodnough, Lawrence T., Jerrold H. Levy, and Michael F. Murphy. “Concepts of blood transfusion in adults.Lancet, May 25, 2013. https://doi.org/10.1016/S0140-6736(13)60650-9.
Goodnough LT, Levy JH, Murphy MF. Concepts of blood transfusion in adults. Vol. 381, Lancet. 2013. p. 1845–54.
Goodnough, Lawrence T., et al. “Concepts of blood transfusion in adults.Lancet, vol. 381, no. 9880, 25 May 2013, pp. 1845–54. Pubmed, doi:10.1016/S0140-6736(13)60650-9.
Goodnough LT, Levy JH, Murphy MF. Concepts of blood transfusion in adults. Lancet. 2013. p. 1845–1854.
Journal cover image

Published In

Lancet

DOI

EISSN

1474-547X

Publication Date

May 25, 2013

Volume

381

Issue

9880

Start / End Page

1845 / 1854

Location

England

Related Subject Headings

  • Transfusion Reaction
  • Randomized Controlled Trials as Topic
  • Professional Practice
  • Practice Guidelines as Topic
  • Postoperative Complications
  • Humans
  • Hemoglobins
  • Guideline Adherence
  • General & Internal Medicine
  • Evidence-Based Medicine