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Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature.

Publication ,  Journal Article
Stauffer, PR; Rodriques, DB; Salahi, S; Topsakal, E; Oliveira, TR; Prakash, A; D'Isidoro, F; Reudink, D; Snow, BW; Maccarini, PF
Published in: Proceedings of SPIE--the International Society for Optical Engineering
February 2013

There are numerous clinical applications for non-invasive monitoring of deep tissue temperature. We present the design and experimental performance of a miniature radiometric thermometry system for measuring volume average temperature of tissue regions located up to 5cm deep in the body.We constructed a miniature sensor consisting of EMI-shielded log spiral microstrip antenna with high gain on-axis and integrated high-sensitivity 1.35GHz total power radiometer with 500 MHz bandwidth. We tested performance of the radiometry system in both simulated and experimental multilayer phantom models of several intended clinical measurement sites: i) brown adipose tissue (BAT) depots within 2cm of the skin surface, ii) 3-5cm deep kidney, and iii) human brain underlying intact scalp and skull. The physical models included layers of circulating tissue-mimicking liquids controlled at different temperatures to characterize our ability to quantify small changes in target temperature at depth under normothermic surface tissues.We report SAR patterns that characterize the sense region of a 2.6cm diameter receive antenna, and radiometric power measurements as a function of deep tissue temperature that quantify radiometer sensitivity. The data demonstrate: i) our ability to accurately track temperature rise in realistic tissue targets such as urine refluxed from prewarmed bladder into kidney, and 10°C drop in brain temperature underlying normothermic scalp and skull, and ii) long term accuracy and stability of ∓0.4°C over 4.5 hours as needed for monitoring core body temperature over extended surgery or monitoring effects of brown fat metabolism over an extended sleep/wake cycle.A non-invasive sensor consisting of 2.6cm diameter receive antenna and integral 1.35GHz total power radiometer has demonstrated sufficient sensitivity to track clinically significant changes in temperature of deep tissue targets underlying normothermic surface tissues for clinical applications like the detection of vesicoureteral reflux, and long term monitoring of brown fat metabolism or brain core temperature during extended surgery.

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Published In

Proceedings of SPIE--the International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

February 2013

Volume

8584

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering
 

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Stauffer, P. R., Rodriques, D. B., Salahi, S., Topsakal, E., Oliveira, T. R., Prakash, A., … Maccarini, P. F. (2013). Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature. Proceedings of SPIE--the International Society for Optical Engineering, 8584. https://doi.org/10.1117/12.2003976
Stauffer, Paul R., Dario B. Rodriques, Sara Salahi, Erdem Topsakal, Tiago R. Oliveira, Aniruddh Prakash, Fabio D’Isidoro, Douglas Reudink, Brent W. Snow, and Paolo F. Maccarini. “Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature.Proceedings of SPIE--the International Society for Optical Engineering 8584 (February 2013). https://doi.org/10.1117/12.2003976.
Stauffer PR, Rodriques DB, Salahi S, Topsakal E, Oliveira TR, Prakash A, et al. Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature. Proceedings of SPIE--the International Society for Optical Engineering. 2013 Feb;8584.
Stauffer, Paul R., et al. “Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature.Proceedings of SPIE--the International Society for Optical Engineering, vol. 8584, Feb. 2013. Epmc, doi:10.1117/12.2003976.
Stauffer PR, Rodriques DB, Salahi S, Topsakal E, Oliveira TR, Prakash A, D’Isidoro F, Reudink D, Snow BW, Maccarini PF. Stable Microwave Radiometry System for Long Term Monitoring of Deep Tissue Temperature. Proceedings of SPIE--the International Society for Optical Engineering. 2013 Feb;8584.

Published In

Proceedings of SPIE--the International Society for Optical Engineering

DOI

EISSN

1996-756X

ISSN

0277-786X

Publication Date

February 2013

Volume

8584

Related Subject Headings

  • 5102 Atomic, molecular and optical physics
  • 4009 Electronics, sensors and digital hardware
  • 4006 Communications engineering