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The pharmacology of novel oral anticoagulants.

Publication ,  Journal Article
DeWald, TA; Becker, RC
Published in: J Thromb Thrombolysis
2014

Anticoagulation for the prevention of stroke is an important aspect of the management of atrial fibrillation. Novel anticoagulants including oral factor Xa inhibitors rivaroxaban and apixaban and the direct thrombin inhibitor dabigatran have emerged as important therapeutic treatment options for prevention of stroke in non-valvular atrial fibrillation. These agents offer practical advantages over traditional vitamin K antagonists, however an understanding of their individual pharmacokinetic and other agent-specific differences is essential for identifying appropriate candidates for therapy, and for selecting the appropriate agent that will be effective and safe. Here, we review the pharmacokinetic process of oral medication use, summarize the newer anticoagulants, their pharmacology, individual pharmacokinetic features, and explore possible explanations for the differences in bleeding outcomes observed in the clinical trials.

Duke Scholars

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

2014

Volume

37

Issue

2

Start / End Page

217 / 233

Location

Netherlands

Related Subject Headings

  • Vitamin K
  • Stroke
  • Humans
  • Hemorrhage
  • Factor Xa Inhibitors
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Anticoagulants
  • Administration, Oral
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
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DeWald, T. A., & Becker, R. C. (2014). The pharmacology of novel oral anticoagulants. J Thromb Thrombolysis, 37(2), 217–233. https://doi.org/10.1007/s11239-013-0967-z
DeWald, Tracy A., and Richard C. Becker. “The pharmacology of novel oral anticoagulants.J Thromb Thrombolysis 37, no. 2 (2014): 217–33. https://doi.org/10.1007/s11239-013-0967-z.
DeWald TA, Becker RC. The pharmacology of novel oral anticoagulants. J Thromb Thrombolysis. 2014;37(2):217–33.
DeWald, Tracy A., and Richard C. Becker. “The pharmacology of novel oral anticoagulants.J Thromb Thrombolysis, vol. 37, no. 2, 2014, pp. 217–33. Pubmed, doi:10.1007/s11239-013-0967-z.
DeWald TA, Becker RC. The pharmacology of novel oral anticoagulants. J Thromb Thrombolysis. 2014;37(2):217–233.
Journal cover image

Published In

J Thromb Thrombolysis

DOI

EISSN

1573-742X

Publication Date

2014

Volume

37

Issue

2

Start / End Page

217 / 233

Location

Netherlands

Related Subject Headings

  • Vitamin K
  • Stroke
  • Humans
  • Hemorrhage
  • Factor Xa Inhibitors
  • Clinical Trials as Topic
  • Cardiovascular System & Hematology
  • Anticoagulants
  • Administration, Oral
  • 3202 Clinical sciences