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Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial.

Publication ,  Journal Article
Wrist and Radius Injury Surgical Trial (WRIST) Study Group,
Published in: J Hand Surg Am
June 2013

The Wrist and Radius Injury Surgery Trial (WRIST) study group is a collaboration of 21 hand surgery centers in the United States, Canada, and Singapore, to showcase the interest and capability of hand surgeons to conduct a multicenter clinical trial. The WRIST study group was formed in response to the seminal systematic review by Margaliot et al and the Cochrane report that indicated marked deficiency in the quality of evidence in the distal radius fracture literature. Since the initial description of this fracture by Colles in 1814, over 2,000 studies have been published on this subject; yet, high-level studies based on the principles of evidence-based medicine are lacking. As we continue to embrace evidence-based medicine to raise the quality of research, the lessons learned during the organization and conduct of WRIST can serve as a template for others contemplating similar efforts. This article traces the course of WRIST by sharing the triumphs and, more important, the struggles faced in the first year of this study.

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Published In

J Hand Surg Am

DOI

EISSN

1531-6564

Publication Date

June 2013

Volume

38

Issue

6

Start / End Page

1194 / 1201

Location

United States

Related Subject Headings

  • Wrist Injuries
  • United States
  • Research Support as Topic
  • Research Design
  • Randomized Controlled Trials as Topic
  • Patient Selection
  • Orthopedics
  • National Institutes of Health (U.S.)
  • Multicenter Studies as Topic
  • Humans
 

Citation

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ICMJE
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Wrist and Radius Injury Surgical Trial (WRIST) Study Group, . (2013). Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial. J Hand Surg Am, 38(6), 1194–1201. https://doi.org/10.1016/j.jhsa.2013.02.027
Wrist and Radius Injury Surgical Trial (WRIST) Study Group, Ehsan. “Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial.J Hand Surg Am 38, no. 6 (June 2013): 1194–1201. https://doi.org/10.1016/j.jhsa.2013.02.027.
Wrist and Radius Injury Surgical Trial (WRIST) Study Group. Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial. J Hand Surg Am. 2013 Jun;38(6):1194–201.
Wrist and Radius Injury Surgical Trial (WRIST) Study Group, Ehsan. “Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial.J Hand Surg Am, vol. 38, no. 6, June 2013, pp. 1194–201. Pubmed, doi:10.1016/j.jhsa.2013.02.027.
Wrist and Radius Injury Surgical Trial (WRIST) Study Group. Reflections 1 year into the 21-Center National Institutes of Health--funded WRIST study: a primer on conducting a multicenter clinical trial. J Hand Surg Am. 2013 Jun;38(6):1194–1201.
Journal cover image

Published In

J Hand Surg Am

DOI

EISSN

1531-6564

Publication Date

June 2013

Volume

38

Issue

6

Start / End Page

1194 / 1201

Location

United States

Related Subject Headings

  • Wrist Injuries
  • United States
  • Research Support as Topic
  • Research Design
  • Randomized Controlled Trials as Topic
  • Patient Selection
  • Orthopedics
  • National Institutes of Health (U.S.)
  • Multicenter Studies as Topic
  • Humans