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Risk factors for ovarian cancers with and without microsatellite instability.

Publication ,  Journal Article
Segev, Y; Pal, T; Rosen, B; McLaughlin, JR; Sellers, TA; Risch, HA; Zhang, S; Ping, S; Narod, SA; Schildkraut, J
Published in: Int J Gynecol Cancer
July 2013

OBJECTIVE: The objective of this study was to evaluate the association between microsatellite instability (MSI) status and (1) ovarian cancer risk factors and (2) the distribution of the specific histologic subtypes in a population-based sample of epithelial ovarian cancers. METHODS: Participants were drawn from 3 population-based studies of primary epithelial ovarian cancer. Tumor DNA was analyzed using 5 standardized microsatellite markers to assess MSI status. Patients were divided into 3 groups (MSI-high, MSI-low, and MSI-stable) according to National Cancer Institute criteria. We compared the prevalence of specific known risk and protective factors among the 3 subgroups, including body mass index, smoking history, parity, BRCA1 and BRCA2 mutation status, past oral contraceptive use, and tubal ligation. Similarly, we compared the distribution of the histologic subtypes among the 3 subgroups. RESULTS: A total of 917 ovarian cancer patients were included. One hundred twenty-seven (13.8%) cancers were MSI-high. Subgroup analyses according to smoking, body mass index, parity, past oral contraceptive use, and past tubal ligation did not reveal any statistically significant differences among the groups. Among the 29 patients with BRCA1 mutations, 20.7% had MSI-high cancers compared with 5.9% among 17 BRCA2-mutation patients. The proportions of different ovarian cancer histologic findings among the various MSI subgroups were similar. CONCLUSIONS: The prevalence of risk and protective factors among ovarian cancer patients is similar for cancers with and without MSI. The distributions of MSI do not differ significantly among ovarian cancers with different histologic findings. Ovarian cancer patients with BRCA1 mutations had a 21% rate of MSI-high tumors, compared with 6% among patients with BRCA2 mutations, but this difference was not statistically significant.

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Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

July 2013

Volume

23

Issue

6

Start / End Page

1010 / 1015

Location

England

Related Subject Headings

  • United States
  • Risk Factors
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Microsatellite Instability
  • Humans
  • Follow-Up Studies
 

Citation

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Chicago
ICMJE
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Segev, Y., Pal, T., Rosen, B., McLaughlin, J. R., Sellers, T. A., Risch, H. A., … Schildkraut, J. (2013). Risk factors for ovarian cancers with and without microsatellite instability. Int J Gynecol Cancer, 23(6), 1010–1015. https://doi.org/10.1097/IGC.0b013e31829a5527
Segev, Yakir, Tuya Pal, Barry Rosen, John R. McLaughlin, Thomas A. Sellers, Harvey A. Risch, Shiyu Zhang, Sun Ping, Steven A. Narod, and Joellen Schildkraut. “Risk factors for ovarian cancers with and without microsatellite instability.Int J Gynecol Cancer 23, no. 6 (July 2013): 1010–15. https://doi.org/10.1097/IGC.0b013e31829a5527.
Segev Y, Pal T, Rosen B, McLaughlin JR, Sellers TA, Risch HA, et al. Risk factors for ovarian cancers with and without microsatellite instability. Int J Gynecol Cancer. 2013 Jul;23(6):1010–5.
Segev, Yakir, et al. “Risk factors for ovarian cancers with and without microsatellite instability.Int J Gynecol Cancer, vol. 23, no. 6, July 2013, pp. 1010–15. Pubmed, doi:10.1097/IGC.0b013e31829a5527.
Segev Y, Pal T, Rosen B, McLaughlin JR, Sellers TA, Risch HA, Zhang S, Ping S, Narod SA, Schildkraut J. Risk factors for ovarian cancers with and without microsatellite instability. Int J Gynecol Cancer. 2013 Jul;23(6):1010–1015.
Journal cover image

Published In

Int J Gynecol Cancer

DOI

EISSN

1525-1438

Publication Date

July 2013

Volume

23

Issue

6

Start / End Page

1010 / 1015

Location

England

Related Subject Headings

  • United States
  • Risk Factors
  • Prognosis
  • Ovarian Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Microsatellite Instability
  • Humans
  • Follow-Up Studies