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APOE ϵ4, rated life experiences, and affect among centenarians.

Publication ,  Journal Article
Martin, P; Jazwinski, SM; Davey, A; Green, RC; Macdonald, M; Margrett, JA; Siegler, IC; Arnold, J; Woodard, JL; Johnson, MA; Kim, S; Dai, J ...
Published in: Aging Ment Health
March 2014

OBJECTIVES: The purpose of this study was to assess the relationship between apolipoprotein E (APOE), life events and engagement, and subjective well-being (as measured by positive and negative affect) among centenarians. Based on the life stress paradigm, we predicted that higher levels of stress would allow APOE to influence positive and negative affect. METHOD: 196 centenarians and near-centenarians (98 years and older) of the Georgia Centenarian Study participated in this research. The APOE, positive and negative affect, the number of recent (last 2 years) and lifelong (more than 20 years prior to testing) events, as well as a number of life engagement tasks were assessed. RESULTS: Results suggested that centenarians carrying the APOE ϵ4 allele rated lower in positive affect, the number of lifelong events, and in engaged lifestyle, when compared to centenarians without the APOE ϵ4 allele (t = 3.43, p < .01; t = 3.19, p < .01; and t = 2.33, p < .05, respectively). Blockwise multiple regressions indicated that the APOE ϵ4 predicted positive but not negative affect after controlling for demographics. Gene-environment interactions were obtained for the APOE ϵ4 and lifelong events, suggesting that carriers of the APOE ϵ4 allele had higher scores of negative affect after having experienced more events, whereas noncarriers had reduced negative affect levels after having experienced more events. CONCLUSION: APOE ϵ4 is directly related to positive affect and is related to negative affect in interaction with life events.

Duke Scholars

Published In

Aging Ment Health

DOI

EISSN

1364-6915

Publication Date

March 2014

Volume

18

Issue

2

Start / End Page

240 / 247

Location

England

Related Subject Headings

  • Quality of Life
  • Male
  • Life Change Events
  • Humans
  • Geriatrics
  • Gene-Environment Interaction
  • Female
  • Apolipoprotein E4
  • Alleles
  • Aging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Martin, P., Jazwinski, S. M., Davey, A., Green, R. C., Macdonald, M., Margrett, J. A., … For The Georgia Centenarian Study, . (2014). APOE ϵ4, rated life experiences, and affect among centenarians. Aging Ment Health, 18(2), 240–247. https://doi.org/10.1080/13607863.2013.827624
Martin, Peter, S Michal Jazwinski, Adam Davey, Robert C. Green, Maurice Macdonald, Jennifer A. Margrett, Ilene C. Siegler, et al. “APOE ϵ4, rated life experiences, and affect among centenarians.Aging Ment Health 18, no. 2 (March 2014): 240–47. https://doi.org/10.1080/13607863.2013.827624.
Martin P, Jazwinski SM, Davey A, Green RC, Macdonald M, Margrett JA, et al. APOE ϵ4, rated life experiences, and affect among centenarians. Aging Ment Health. 2014 Mar;18(2):240–7.
Martin, Peter, et al. “APOE ϵ4, rated life experiences, and affect among centenarians.Aging Ment Health, vol. 18, no. 2, Mar. 2014, pp. 240–47. Pubmed, doi:10.1080/13607863.2013.827624.
Martin P, Jazwinski SM, Davey A, Green RC, Macdonald M, Margrett JA, Siegler IC, Arnold J, Woodard JL, Johnson MA, Kim S, Dai J, Li L, Batzer MA, Poon LW, For The Georgia Centenarian Study. APOE ϵ4, rated life experiences, and affect among centenarians. Aging Ment Health. 2014 Mar;18(2):240–247.

Published In

Aging Ment Health

DOI

EISSN

1364-6915

Publication Date

March 2014

Volume

18

Issue

2

Start / End Page

240 / 247

Location

England

Related Subject Headings

  • Quality of Life
  • Male
  • Life Change Events
  • Humans
  • Geriatrics
  • Gene-Environment Interaction
  • Female
  • Apolipoprotein E4
  • Alleles
  • Aging