Plasmonic nanoprobes: from chemical sensing to medical diagnostics and therapy.
This article provides an overview of the development and applications of plasmonics-active nanoprobes in our laboratory for chemical sensing, medical diagnostics and therapy. Molecular Sentinel nanoprobes provide a unique tool for DNA/RNA biomarker detection both in a homogeneous solution or on a chip platform for medical diagnostics. The possibility of combining spectral selectivity and high sensitivity of the surface-enhanced Raman scattering (SERS) process with the inherent molecular specificity of nanoprobes provides an important multiplex diagnostic modality. Gold nanostars can provide an excellent multi-modality platform, combining two-photon luminescence with photothermal therapy as well as Raman imaging with photodynamic therapy. Several examples of optical detection using SERS and photonics-based treatments are presented to illustrate the usefulness and potential of the plasmonic nanoprobes for theranostics, which seamlessly combines diagnostics and therapy.
Duke Scholars
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Related Subject Headings
- Spectrum Analysis, Raman
- Photosensitizing Agents
- Photochemotherapy
- Neoplasms
- Nanostructures
- Nanoscience & Nanotechnology
- Humans
- Gold
- DNA
- Biosensing Techniques
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Spectrum Analysis, Raman
- Photosensitizing Agents
- Photochemotherapy
- Neoplasms
- Nanostructures
- Nanoscience & Nanotechnology
- Humans
- Gold
- DNA
- Biosensing Techniques