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Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.

Publication ,  Journal Article
Hull, CA; Chu, Y; Thanawala, M; Regehr, WG
Published in: J Neurosci
April 3, 2013

Golgi cells (GoCs) are inhibitory interneurons that influence the cerebellar cortical response to sensory input by regulating the excitability of the granule cell layer. While GoC inhibition is essential for normal motor coordination, little is known about the circuit dynamics that govern the activity of these cells. In particular, although GoC spontaneous spiking influences the extent of inhibition and gain throughout the granule cell layer, it is not known whether this spontaneous activity can be modulated in a long-term manner. Here we describe a form of long-term plasticity that regulates the spontaneous firing rate of GoCs in the rat cerebellar cortex. We find that membrane hyperpolarization, either by mGluR2 activation of potassium channels, or by somatic current injection, induces a long-lasting increase in GoC spontaneous firing. This spike rate plasticity appears to result from a strong reduction in the spike after hyperpolarization. Pharmacological manipulations suggest the involvement of calcium-calmodulin-dependent kinase II and calcium-activated potassium channels in mediating these firing rate increases. As a consequence of this plasticity, GoC spontaneous spiking is selectively enhanced, but the gain of evoked spiking is unaffected. Hence, this plasticity is well suited for selectively regulating the tonic output of GoCs rather than their sensory-evoked responses.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 3, 2013

Volume

33

Issue

14

Start / End Page

5895 / 5902

Location

United States

Related Subject Headings

  • Time Factors
  • Receptors, Metabotropic Glutamate
  • Rats, Sprague-Dawley
  • Rats
  • Propanolamines
  • Potassium Channels, Calcium-Activated
  • Phosphinic Acids
  • Patch-Clamp Techniques
  • Neurology & Neurosurgery
  • Male
 

Citation

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MLA
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Hull, C. A., Chu, Y., Thanawala, M., & Regehr, W. G. (2013). Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci, 33(14), 5895–5902. https://doi.org/10.1523/JNEUROSCI.4052-12.2013
Hull, Court A., YunXiang Chu, Monica Thanawala, and Wade G. Regehr. “Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.J Neurosci 33, no. 14 (April 3, 2013): 5895–5902. https://doi.org/10.1523/JNEUROSCI.4052-12.2013.
Hull CA, Chu Y, Thanawala M, Regehr WG. Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci. 2013 Apr 3;33(14):5895–902.
Hull, Court A., et al. “Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells.J Neurosci, vol. 33, no. 14, Apr. 2013, pp. 5895–902. Pubmed, doi:10.1523/JNEUROSCI.4052-12.2013.
Hull CA, Chu Y, Thanawala M, Regehr WG. Hyperpolarization induces a long-term increase in the spontaneous firing rate of cerebellar Golgi cells. J Neurosci. 2013 Apr 3;33(14):5895–5902.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 3, 2013

Volume

33

Issue

14

Start / End Page

5895 / 5902

Location

United States

Related Subject Headings

  • Time Factors
  • Receptors, Metabotropic Glutamate
  • Rats, Sprague-Dawley
  • Rats
  • Propanolamines
  • Potassium Channels, Calcium-Activated
  • Phosphinic Acids
  • Patch-Clamp Techniques
  • Neurology & Neurosurgery
  • Male