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Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.

Publication ,  Journal Article
Hull, C; Regehr, WG
Published in: Neuron
January 12, 2012

Here we provide evidence that revises the inhibitory circuit diagram of the cerebellar cortex. It was previously thought that Golgi cells, interneurons that are the sole source of inhibition onto granule cells, were exclusively coupled via gap junctions. Moreover, Golgi cells were believed to receive GABAergic inhibition from molecular layer interneurons (MLIs). Here we challenge these views by optogenetically activating the cerebellar circuitry to determine the timing and pharmacology of inhibition onto Golgi cells and by performing paired recordings to directly assess synaptic connectivity. In contrast to current thought, we find that Golgi cells, not MLIs, make inhibitory GABAergic synapses onto other Golgi cells. As a result, MLI feedback does not regulate the Golgi cell network, and Golgi cells are inhibited approximately 2 ms before Purkinje cells, following a mossy fiber input. Hence, Golgi cells and Purkinje cells receive unique sources of inhibition and can differentially process shared granule cell inputs.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

January 12, 2012

Volume

73

Issue

1

Start / End Page

149 / 158

Location

United States

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  • Neurology & Neurosurgery
 

Citation

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Hull, C., & Regehr, W. G. (2012). Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity. Neuron, 73(1), 149–158. https://doi.org/10.1016/j.neuron.2011.10.030
Hull, Court, and Wade G. Regehr. “Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.Neuron 73, no. 1 (January 12, 2012): 149–58. https://doi.org/10.1016/j.neuron.2011.10.030.
Hull, Court, and Wade G. Regehr. “Identification of an inhibitory circuit that regulates cerebellar Golgi cell activity.Neuron, vol. 73, no. 1, Jan. 2012, pp. 149–58. Pubmed, doi:10.1016/j.neuron.2011.10.030.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

January 12, 2012

Volume

73

Issue

1

Start / End Page

149 / 158

Location

United States

Related Subject Headings

  • Transfection
  • Thy-1 Antigens
  • Rats, Sprague-Dawley
  • Rats
  • Quinoxalines
  • Pyridazines
  • Piperazines
  • Patch-Clamp Techniques
  • Neurons
  • Neurology & Neurosurgery