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Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.

Publication ,  Journal Article
Hull, C; Adesnik, H; Scanziani, M
Published in: J Neurosci
July 15, 2009

In his theory of functional polarity, Ramon y Cajal first identified the soma and dendrites as the principal recipient compartments of a neuron and the axon as its main output structure. Despite notable exceptions in other parts of the nervous system (Schoppa and Urban, 2003; Wässle, 2004; Howard et al., 2005), this route of signal propagation has been shown to underlie the functional properties of most neocortical circuits studied so far. Recent evidence, however, suggests that neocortical excitatory cells may trigger the release of the inhibitory neurotransmitter GABA by directly depolarizing the axon terminals of inhibitory interneurons, thus bypassing their somatodendritic compartments (Ren et al., 2007). By using a combination of optical and electrophysiological approaches, we find that synaptically released glutamate fails to trigger GABA release through a direct action on GABAergic terminals under physiological conditions. Rather, our evidence suggests that glutamate triggers GABA release only after somatodendritic depolarization and action potential generation at GABAergic interneurons. These data indicate that neocortical inhibition is recruited by classical somatodendritic integration rather than direct activation of interneuron axon terminals.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

July 15, 2009

Volume

29

Issue

28

Start / End Page

8991 / 8995

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Tetrodotoxin
  • Synapses
  • Sodium Channel Blockers
  • Reaction Time
  • Rats, Wistar
  • Rats
  • Potassium Channel Blockers
  • Photic Stimulation
  • Patch-Clamp Techniques
 

Citation

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Hull, C., Adesnik, H., & Scanziani, M. (2009). Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. J Neurosci, 29(28), 8991–8995. https://doi.org/10.1523/JNEUROSCI.5717-08.2009
Hull, Court, Hillel Adesnik, and Massimo Scanziani. “Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.J Neurosci 29, no. 28 (July 15, 2009): 8991–95. https://doi.org/10.1523/JNEUROSCI.5717-08.2009.
Hull C, Adesnik H, Scanziani M. Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. J Neurosci. 2009 Jul 15;29(28):8991–5.
Hull, Court, et al. “Neocortical disynaptic inhibition requires somatodendritic integration in interneurons.J Neurosci, vol. 29, no. 28, July 2009, pp. 8991–95. Pubmed, doi:10.1523/JNEUROSCI.5717-08.2009.
Hull C, Adesnik H, Scanziani M. Neocortical disynaptic inhibition requires somatodendritic integration in interneurons. J Neurosci. 2009 Jul 15;29(28):8991–8995.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

July 15, 2009

Volume

29

Issue

28

Start / End Page

8991 / 8995

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Tetrodotoxin
  • Synapses
  • Sodium Channel Blockers
  • Reaction Time
  • Rats, Wistar
  • Rats
  • Potassium Channel Blockers
  • Photic Stimulation
  • Patch-Clamp Techniques