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Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.

Publication ,  Journal Article
Vigh, J; Li, G-L; Hull, C; von Gersdorff, H
Published in: Neuron
May 5, 2005
Published version (DOI) Link to item

The flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2-3 ms) and transient GABA(A) IPSCs and a much slower and more sustained GABA(C) feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.

Duke Scholars

Court Alan Hull
Author Court Alan Hull Neurobiology

Published In

Neuron

DOI

10.1016/j.neuron.2005.03.027

ISSN

0896-6273

Publication Date

May 5, 2005

Volume

46

Issue

3

Start / End Page

469 / 482

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Retina
  • Receptors, Metabotropic Glutamate
  • Receptors, GABA
  • Patch-Clamp Techniques
  • Organ Culture Techniques
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Goldfish
 

Citation

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ICMJE
MLA
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Vigh, J., Li, G.-L., Hull, C., & von Gersdorff, H. (2005). Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse. Neuron, 46(3), 469–482. https://doi.org/10.1016/j.neuron.2005.03.027
Vigh, Jozsef, Geng-Lin Li, Court Hull, and Henrique von Gersdorff. “Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.” Neuron 46, no. 3 (May 5, 2005): 469–82. https://doi.org/10.1016/j.neuron.2005.03.027.
Vigh J, Li G-L, Hull C, von Gersdorff H. Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse. Neuron. 2005 May 5;46(3):469–82.
Vigh, Jozsef, et al. “Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse.” Neuron, vol. 46, no. 3, May 2005, pp. 469–82. Pubmed, doi:10.1016/j.neuron.2005.03.027.
Vigh J, Li G-L, Hull C, von Gersdorff H. Long-term plasticity mediated by mGluR1 at a retinal reciprocal synapse. Neuron. 2005 May 5;46(3):469–482.
Journal cover image

Published In

Neuron

DOI

10.1016/j.neuron.2005.03.027

ISSN

0896-6273

Publication Date

May 5, 2005

Volume

46

Issue

3

Start / End Page

469 / 482

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synapses
  • Retina
  • Receptors, Metabotropic Glutamate
  • Receptors, GABA
  • Patch-Clamp Techniques
  • Organ Culture Techniques
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Goldfish