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Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas.

Publication ,  Other
Levy, JH
Published in: Hematol Oncol Clin North Am
February 2007

Hemostatic abnormalities occur following injury associated with both cardiac and noncardiac surgery. These changes are part of inflammatory pathways with signaling mechanisms that link these diverse pathways. The inflammatory response to surgery is exacerbated by allogeneic blood transfusion by enhancing intrinsic inflammatory activity and directly increasing plasma levels of inflammatory mediators. Surgical patients can be preventively treated with pharmacologic agents to modulate inflammatory responses. Multiple studies have reported preventive pharmacologic therapies to reduce bleeding and the need for allogeneic transfusions in surgery. Strategies for cardiac surgical patients during cardiopulmonary bypass include administration of either lysine analogs, such as epsilon aminocaproic acid and tranexamic acid, or the serine protease inhibitor aprotinin.

Duke Scholars

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

February 2007

Volume

21

Issue

1

Start / End Page

89 / 101

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Inflammation
  • Humans
  • Hemostatics
  • Hemostasis
  • Anti-Inflammatory Agents
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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ICMJE
MLA
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Levy, J. H. (2007). Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas. Hematol Oncol Clin North Am. United States. https://doi.org/10.1016/j.hoc.2006.11.007
Levy, Jerrold H. “Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas.Hematol Oncol Clin North Am, February 2007. https://doi.org/10.1016/j.hoc.2006.11.007.
Levy JH. Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas. Vol. 21, Hematol Oncol Clin North Am. 2007. p. 89–101.
Levy, Jerrold H. “Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas.Hematol Oncol Clin North Am, vol. 21, no. 1, Feb. 2007, pp. 89–101. Pubmed, doi:10.1016/j.hoc.2006.11.007.
Levy JH. Anti-inflammatory strategies and hemostatic agents: old drugs, new ideas. Hematol Oncol Clin North Am. 2007. p. 89–101.
Journal cover image

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

February 2007

Volume

21

Issue

1

Start / End Page

89 / 101

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Inflammation
  • Humans
  • Hemostatics
  • Hemostasis
  • Anti-Inflammatory Agents
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology