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The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery.

Publication ,  Journal Article
Sato, N; Tanaka, KA; Szlam, F; Tsuda, A; Arias, ME; Levy, JH
Published in: Anesth Analg
February 2003

We studied the effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam (a dopamine D1-agonist) on isolated human umbilical arteries (HUA) from patients classified as normotensive and with pregnancy-induced hypertension (PIH). Umbilical artery rings were contracted with the thromboxane A(2) analog (U46619; 10(-8) M) and then exposed to cumulative concentrations of fenoldopam, hydralazine, nicardipine, and nitroglycerin. Second, rings were preexposed to prazosin (10(-5) M), phenoxybenzamine (10(-5) M), or none, and the constriction responses to increasing doses of fenoldopam or dopamine were recorded. Nitroglycerin, hydralazine, and nicardipine produced concentration-dependent relaxation of U46619-preconstricted HUA segments from normotensive and PIH patients. Fenoldopam and dopamine induced umbilical artery constriction in both normal and PIH rings at concentrations > or = 10(-5) M and > or = 10(-3) M, respectively. Phenoxybenzamine, but not prazosin, pretreatment irreversibly abolished fenoldopam-induced contraction. In this in vitro study, nitroglycerin was the most potent vasodilator of the HUA constricted with U46619, followed by nicardipine and hydralazine. However, fenoldopam constricted HUA rings only at supratherapeutic concentrations. No significant differences of vascular responses to fenoldopam (P = 0.3534), nitroglycerin (P = 0.7416), nicardipine (P = 0.0615), and hydralazine (P = 0.5514) between rings from normotensive or hypertensive pregnant patients were shown.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 2003

Volume

96

Issue

2

Start / End Page

539 / 544

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasoconstrictor Agents
  • Umbilical Arteries
  • Thromboxane A2
  • Receptors, Adrenergic, alpha
  • Pregnancy
  • Pre-Eclampsia
  • Potassium Chloride
  • Nitroglycerin
  • Nicardipine
 

Citation

APA
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Sato, N., Tanaka, K. A., Szlam, F., Tsuda, A., Arias, M. E., & Levy, J. H. (2003). The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesth Analg, 96(2), 539–544. https://doi.org/10.1097/00000539-200302000-00044
Sato, Nobukazu, Kenichi A. Tanaka, Fania Szlam, Atsushi Tsuda, Maria E. Arias, and Jerrold H. Levy. “The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery.Anesth Analg 96, no. 2 (February 2003): 539–44. https://doi.org/10.1097/00000539-200302000-00044.
Sato N, Tanaka KA, Szlam F, Tsuda A, Arias ME, Levy JH. The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesth Analg. 2003 Feb;96(2):539–44.
Sato, Nobukazu, et al. “The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery.Anesth Analg, vol. 96, no. 2, Feb. 2003, pp. 539–44. Pubmed, doi:10.1097/00000539-200302000-00044.
Sato N, Tanaka KA, Szlam F, Tsuda A, Arias ME, Levy JH. The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesth Analg. 2003 Feb;96(2):539–544.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

February 2003

Volume

96

Issue

2

Start / End Page

539 / 544

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasoconstrictor Agents
  • Umbilical Arteries
  • Thromboxane A2
  • Receptors, Adrenergic, alpha
  • Pregnancy
  • Pre-Eclampsia
  • Potassium Chloride
  • Nitroglycerin
  • Nicardipine