Intravenous milrinone in cardiac surgery.
Phosphodiesterase inhibitors including milrinone produce positive inotropic effects by slowing the hydrolysis of cyclic adenosine monophosphate in the myocardium. With a loading dose of 50 microg/kg followed by an infusion of 0.5 microg x kg(-1) x min(-1), milrinone increases stroke volume index and left ventricular velocity of circumferential fiber shortening after weaning from cardiopulmonary bypass. Milrinone has potential for the treatment and prevention of internal mammary artery spasm because of its vasodilative effect, which is similar to that of papaverine, and is a potent pulmonary vasodilator for patients with right ventricular dysfunction and pulmonary vasoconstriction. Low-dose milrinone may have antiinflammatory properties and potentially can improve splanchnic perfusion.
Duke Scholars
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Related Subject Headings
- Ventricular Function
- Respiratory System
- Phosphodiesterase Inhibitors
- Milrinone
- Humans
- Hemodynamics
- Heart Transplantation
- Heart
- Cardiotonic Agents
- Cardiopulmonary Bypass
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Ventricular Function
- Respiratory System
- Phosphodiesterase Inhibitors
- Milrinone
- Humans
- Hemodynamics
- Heart Transplantation
- Heart
- Cardiotonic Agents
- Cardiopulmonary Bypass