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Intravenous milrinone in cardiac surgery.

Publication ,  Other
Levy, JH; Bailey, JM; Deeb, GM
Published in: Ann Thorac Surg
January 2002

Phosphodiesterase inhibitors including milrinone produce positive inotropic effects by slowing the hydrolysis of cyclic adenosine monophosphate in the myocardium. With a loading dose of 50 microg/kg followed by an infusion of 0.5 microg x kg(-1) x min(-1), milrinone increases stroke volume index and left ventricular velocity of circumferential fiber shortening after weaning from cardiopulmonary bypass. Milrinone has potential for the treatment and prevention of internal mammary artery spasm because of its vasodilative effect, which is similar to that of papaverine, and is a potent pulmonary vasodilator for patients with right ventricular dysfunction and pulmonary vasoconstriction. Low-dose milrinone may have antiinflammatory properties and potentially can improve splanchnic perfusion.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

January 2002

Volume

73

Issue

1

Start / End Page

325 / 330

Location

Netherlands

Related Subject Headings

  • Ventricular Function
  • Respiratory System
  • Phosphodiesterase Inhibitors
  • Milrinone
  • Humans
  • Hemodynamics
  • Heart Transplantation
  • Heart
  • Cardiotonic Agents
  • Cardiopulmonary Bypass
 

Citation

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ICMJE
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Levy, J. H., Bailey, J. M., & Deeb, G. M. (2002). Intravenous milrinone in cardiac surgery. Ann Thorac Surg. Netherlands. https://doi.org/10.1016/s0003-4975(01)02719-9
Levy, Jerrold H., James M. Bailey, and G Michael Deeb. “Intravenous milrinone in cardiac surgery.Ann Thorac Surg, January 2002. https://doi.org/10.1016/s0003-4975(01)02719-9.
Levy JH, Bailey JM, Deeb GM. Intravenous milrinone in cardiac surgery. Vol. 73, Ann Thorac Surg. 2002. p. 325–30.
Levy, Jerrold H., et al. “Intravenous milrinone in cardiac surgery.Ann Thorac Surg, vol. 73, no. 1, Jan. 2002, pp. 325–30. Pubmed, doi:10.1016/s0003-4975(01)02719-9.
Levy JH, Bailey JM, Deeb GM. Intravenous milrinone in cardiac surgery. Ann Thorac Surg. 2002. p. 325–330.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

January 2002

Volume

73

Issue

1

Start / End Page

325 / 330

Location

Netherlands

Related Subject Headings

  • Ventricular Function
  • Respiratory System
  • Phosphodiesterase Inhibitors
  • Milrinone
  • Humans
  • Hemodynamics
  • Heart Transplantation
  • Heart
  • Cardiotonic Agents
  • Cardiopulmonary Bypass