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The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery.

Publication ,  Journal Article
Tsuda, A; Tanaka, KA; Huraux, C; Szlam, F; Sato, N; Yamaguchi, K; Levy, JH
Published in: Anesth Analg
December 2001

UNLABELLED: Anaphylactic shock therapy includes the use of catecholamines but they may not always be effective. Because vasodilation during anaphylaxis is a result of the endothelial release of multiple mediators, we investigated the effects of epinephrine, vasopressin, and inhibitors of nitric oxide and prostanoid pathways on histamine-induced relaxation in human internal mammary artery. The vessel segments were obtained intraoperatively and were suspended in organ chambers to record isometric tension. Norepinephrine (10(-6) M) was used to precontract the rings followed by histamine (10(-6.5) M) to relax the vessels and mimic vascular collapse. Epinephrine, vasopressin, methylene blue, N(G)-monomethyl-L-arginine (L-NMA) and indomethacin were added in a cumulative fashion to reverse the histamine-induced vasodilation. The internal mammary artery segments exhibited greater contraction in the presence of the epinephrine (4.9 +/- 0.7 g) compared with vasopressin (2.6 +/- 0.7 g). Vasopressin (10(-11) to 10(-7) M), methylene blue (10(-7) to 10(-5) M), L-NMA (10(-6) to 10(-4) M), and indomethacin (10(-7) to 10(-5) M) were only partially effective. These findings suggest that vasopressin and methylene blue may offer a potential therapeutic option in the treatment of histamine-induced vasodilatory shock. IMPLICATIONS: Epinephrine only partially reverses histamine-induced vasodilation in human internal mammary arteries, whereas vasopressin, methylene blue, and drugs involved in the inhibition of nitric oxide and prostaglandin generation lead to a complete reversal of the vascular relaxation.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

December 2001

Volume

93

Issue

6

Start / End Page

1453 / 1459

Location

United States

Related Subject Headings

  • omega-N-Methylarginine
  • Vasopressins
  • Vasodilator Agents
  • Vasodilation
  • Methylene Blue
  • Mammary Arteries
  • Indomethacin
  • In Vitro Techniques
  • Humans
  • Histamine
 

Citation

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MLA
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Tsuda, A., Tanaka, K. A., Huraux, C., Szlam, F., Sato, N., Yamaguchi, K., & Levy, J. H. (2001). The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. Anesth Analg, 93(6), 1453–1459. https://doi.org/10.1097/00000539-200112000-00020
Tsuda, A., K. A. Tanaka, C. Huraux, F. Szlam, N. Sato, K. Yamaguchi, and J. H. Levy. “The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery.Anesth Analg 93, no. 6 (December 2001): 1453–59. https://doi.org/10.1097/00000539-200112000-00020.
Tsuda A, Tanaka KA, Huraux C, Szlam F, Sato N, Yamaguchi K, et al. The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. Anesth Analg. 2001 Dec;93(6):1453–9.
Tsuda, A., et al. “The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery.Anesth Analg, vol. 93, no. 6, Dec. 2001, pp. 1453–59. Pubmed, doi:10.1097/00000539-200112000-00020.
Tsuda A, Tanaka KA, Huraux C, Szlam F, Sato N, Yamaguchi K, Levy JH. The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery. Anesth Analg. 2001 Dec;93(6):1453–1459.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

December 2001

Volume

93

Issue

6

Start / End Page

1453 / 1459

Location

United States

Related Subject Headings

  • omega-N-Methylarginine
  • Vasopressins
  • Vasodilator Agents
  • Vasodilation
  • Methylene Blue
  • Mammary Arteries
  • Indomethacin
  • In Vitro Techniques
  • Humans
  • Histamine