Skip to main content
Journal cover image

Pharmacologic preservation of the hemostatic system during cardiac surgery.

Publication ,  Other
Levy, JH
Published in: Ann Thorac Surg
November 2001

Bleeding after cardiac surgery remains a major potential problem. Numerous pharmacologic approaches to attenuating hemostatic system activation in cardiac surgery patients have been studied to further improve patient management. Therapeutic approaches studied include inhibiting thrombin generation or activation, preserving platelet function, and decreasing the need for transfusion of allogeneic blood products. Pharmacologic approaches to reduce bleeding and transfusion requirements in cardiac surgery patients are based on either preventing or reversing the defects associated with the CPB-induced coagulopathy. The increasing use of platelet inhibitors (clopidogrel and IIb/IIIa receptor antagonists) and new anticoagulants (low-molecular weight heparins, pentasaccharide, recombinant hirudin, bivalirudin, and argatroban) also pose interesting problems in managing cardiac surgery patients. Aprotinin and lysine analogues (epsilon-aminocaproic acid and tranexamic acid) have become mainstay therapeutic agents to prevent bleeding and the potential need for allogeneic transfusion. Newer therapies that are important to consider include the potential of recombinant activated factor VIIa as a therapy for refractory bleeding after cardiac surgery.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 2001

Volume

72

Issue

5

Start / End Page

S1814 / S1820

Location

Netherlands

Related Subject Headings

  • Respiratory System
  • Intraoperative Care
  • Humans
  • Hemostasis
  • Fibrinolytic Agents
  • Cardiopulmonary Bypass
  • Blood Loss, Surgical
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Levy, J. H. (2001). Pharmacologic preservation of the hemostatic system during cardiac surgery. Ann Thorac Surg. Netherlands. https://doi.org/10.1016/s0003-4975(01)03218-0
Levy, J. H. “Pharmacologic preservation of the hemostatic system during cardiac surgery.Ann Thorac Surg, November 2001. https://doi.org/10.1016/s0003-4975(01)03218-0.
Levy JH. Pharmacologic preservation of the hemostatic system during cardiac surgery. Vol. 72, Ann Thorac Surg. 2001. p. S1814–20.
Levy, J. H. “Pharmacologic preservation of the hemostatic system during cardiac surgery.Ann Thorac Surg, vol. 72, no. 5, Nov. 2001, pp. S1814–20. Pubmed, doi:10.1016/s0003-4975(01)03218-0.
Levy JH. Pharmacologic preservation of the hemostatic system during cardiac surgery. Ann Thorac Surg. 2001. p. S1814–S1820.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

November 2001

Volume

72

Issue

5

Start / End Page

S1814 / S1820

Location

Netherlands

Related Subject Headings

  • Respiratory System
  • Intraoperative Care
  • Humans
  • Hemostasis
  • Fibrinolytic Agents
  • Cardiopulmonary Bypass
  • Blood Loss, Surgical
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology