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Weal and flare responses to intradermal rocuronium and cisatracurium in humans.

Publication ,  Journal Article
Levy, JH; Gottge, M; Szlam, F; Zaffer, R; McCall, C
Published in: Br J Anaesth
December 2000

Thirty volunteers underwent intradermal skin testing with increasing concentrations of rocuronium and cisatracurium to evaluate weal and flare responses, and whether either agent would cause mast cell degranulation and sensitization upon re-exposure. We found that intradermal injection of rocuronium and cisatracurium at concentrations > 10(-4) M resulted in positive weal (>8 mm) responses, and positive flare responses at > 10(-4) and > 10(-5) M respectively. Only cisatracurium caused mild to moderate mast cell degranulation, and neither drug caused significant in vitro histamine release from whole blood collected from study subjects 4 weeks after skin testing. Skin testing with rocuronium and cisatracurium should be performed at concentrations < 10(-4) and < 10(-5) M respectively to avoid false-positive responses. The ability of these agents to produce positive weal and flare responses at relatively low concentrations may explain the high incidence of potential reactions reported.

Duke Scholars

Published In

Br J Anaesth

DOI

ISSN

0007-0912

Publication Date

December 2000

Volume

85

Issue

6

Start / End Page

844 / 849

Location

England

Related Subject Headings

  • Urticaria
  • Skin
  • Rocuronium
  • Neuromuscular Nondepolarizing Agents
  • Mast Cells
  • Intradermal Tests
  • Humans
  • Histamine Release
  • Drug Eruptions
  • Dose-Response Relationship, Drug
 

Citation

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Levy, J. H., Gottge, M., Szlam, F., Zaffer, R., & McCall, C. (2000). Weal and flare responses to intradermal rocuronium and cisatracurium in humans. Br J Anaesth, 85(6), 844–849. https://doi.org/10.1093/bja/85.6.844
Levy, J. H., M. Gottge, F. Szlam, R. Zaffer, and C. McCall. “Weal and flare responses to intradermal rocuronium and cisatracurium in humans.Br J Anaesth 85, no. 6 (December 2000): 844–49. https://doi.org/10.1093/bja/85.6.844.
Levy JH, Gottge M, Szlam F, Zaffer R, McCall C. Weal and flare responses to intradermal rocuronium and cisatracurium in humans. Br J Anaesth. 2000 Dec;85(6):844–9.
Levy, J. H., et al. “Weal and flare responses to intradermal rocuronium and cisatracurium in humans.Br J Anaesth, vol. 85, no. 6, Dec. 2000, pp. 844–49. Pubmed, doi:10.1093/bja/85.6.844.
Levy JH, Gottge M, Szlam F, Zaffer R, McCall C. Weal and flare responses to intradermal rocuronium and cisatracurium in humans. Br J Anaesth. 2000 Dec;85(6):844–849.
Journal cover image

Published In

Br J Anaesth

DOI

ISSN

0007-0912

Publication Date

December 2000

Volume

85

Issue

6

Start / End Page

844 / 849

Location

England

Related Subject Headings

  • Urticaria
  • Skin
  • Rocuronium
  • Neuromuscular Nondepolarizing Agents
  • Mast Cells
  • Intradermal Tests
  • Humans
  • Histamine Release
  • Drug Eruptions
  • Dose-Response Relationship, Drug