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Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques.

Publication ,  Journal Article
Despotis, GJ; Gravlee, G; Filos, K; Levy, J
Published in: Anesthesiology
October 1999

The literature does not consistently support the importance of anticoagulation monitoring techniques during CPB. This is best reflected by studies that have evaluated the impact of the ACT method on blood loss and transfusion outcomes. Inconsistent findings from studies that evaluated the impact of ACT monitoring may be related to either suboptimal study design (i.e., retrospective, unblinded, nonrandomized) or possibly the diagnostic inprecision of the ACT method used in these studies. There are a small number of well-controlled studies, some of which suggest that bleeding and transfusion outcomes can be improved by refining heparin monitoring techniques, either by sustaining better anticoagulation during CPB or by optimizing protamine doses (i.e., when empiric protocols result in excessive protamine doses). More well-controlled studies are needed to better define the importance of anticoagulation management during CPB.

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Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

October 1999

Volume

91

Issue

4

Start / End Page

1122 / 1151

Location

United States

Related Subject Headings

  • Monitoring, Intraoperative
  • Humans
  • Cardiac Surgical Procedures
  • Anticoagulants
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Despotis, G. J., Gravlee, G., Filos, K., & Levy, J. (1999). Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques. Anesthesiology, 91(4), 1122–1151. https://doi.org/10.1097/00000542-199910000-00031
Despotis, G. J., G. Gravlee, K. Filos, and J. Levy. “Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques.Anesthesiology 91, no. 4 (October 1999): 1122–51. https://doi.org/10.1097/00000542-199910000-00031.
Despotis GJ, Gravlee G, Filos K, Levy J. Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques. Anesthesiology. 1999 Oct;91(4):1122–51.
Despotis, G. J., et al. “Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques.Anesthesiology, vol. 91, no. 4, Oct. 1999, pp. 1122–51. Pubmed, doi:10.1097/00000542-199910000-00031.
Despotis GJ, Gravlee G, Filos K, Levy J. Anticoagulation monitoring during cardiac surgery: a review of current and emerging techniques. Anesthesiology. 1999 Oct;91(4):1122–1151.

Published In

Anesthesiology

DOI

ISSN

0003-3022

Publication Date

October 1999

Volume

91

Issue

4

Start / End Page

1122 / 1151

Location

United States

Related Subject Headings

  • Monitoring, Intraoperative
  • Humans
  • Cardiac Surgical Procedures
  • Anticoagulants
  • Animals
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences