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The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia.

Publication ,  Journal Article
Levy, JH; Pitts, M; Thanopoulos, A; Szlam, F; Bastian, R; Kim, J
Published in: Anesth Analg
August 1999

UNLABELLED: Neuromuscular blocking drugs may have variable effects on heart rate (HR) and blood pressure. Rapacuronium is a rapid-acting, steroidal-derived neuromuscular blocking drug whose hemodynamic effects have not been characterized. We studied the effects of 1, 2, and 3 mg/kg rapacuronium on histamine release, HR, and blood pressure in 47 ASA physical status II or III adult patients after the induction of anesthesia with etomidate/fentanyl/N2O. Plasma histamine concentrations were measured before induction and immediately before and 1, 3, and 5 min after the rapid administration of rapacuronium. Mean arterial pressure (MAP) decreased after rapacuronium administration, but there were no significant differences among the groups for changes in HR or MAP, and there was no correlation between changes in MAP or HR and increases in histamine levels. There were no changes in HR or MAP among five patients who had significant (> or = 1 ng/mL) increases in histamine from baselin. Seven patients had bronchospasm without increases in plasma histamine levels. Rapacuronium 2-3 mg/kg increased plasma histamine levels. However, clinically significant histamine-related sequelae did not occur in this population with 1- to 3-mg/kg doses of rapacuronium, and cardiovascular changes were not directly correlated with histamine release. Rapacuronium administration can produce hypotension via mechanisms that do not seem to be related to histamine release. IMPLICATIONS: Rapacuronium, a new steroidal-derived muscle relaxant, may release histamine and produce slight changes in blood pressure and heart rate after administration.

Duke Scholars

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

August 1999

Volume

89

Issue

2

Start / End Page

290 / 295

Location

United States

Related Subject Headings

  • Vecuronium Bromide
  • Neuromuscular Nondepolarizing Agents
  • Middle Aged
  • Male
  • Humans
  • Histamine Release
  • Histamine
  • Hemodynamics
  • Heart Rate
  • Female
 

Citation

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Levy, J. H., Pitts, M., Thanopoulos, A., Szlam, F., Bastian, R., & Kim, J. (1999). The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia. Anesth Analg, 89(2), 290–295. https://doi.org/10.1097/00000539-199908000-00005
Levy, J. H., M. Pitts, A. Thanopoulos, F. Szlam, R. Bastian, and J. Kim. “The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia.Anesth Analg 89, no. 2 (August 1999): 290–95. https://doi.org/10.1097/00000539-199908000-00005.
Levy JH, Pitts M, Thanopoulos A, Szlam F, Bastian R, Kim J. The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia. Anesth Analg. 1999 Aug;89(2):290–5.
Levy, J. H., et al. “The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia.Anesth Analg, vol. 89, no. 2, Aug. 1999, pp. 290–95. Pubmed, doi:10.1097/00000539-199908000-00005.
Levy JH, Pitts M, Thanopoulos A, Szlam F, Bastian R, Kim J. The effects of rapacuronium on histamine release and hemodynamics in adult patients undergoing general anesthesia. Anesth Analg. 1999 Aug;89(2):290–295.

Published In

Anesth Analg

DOI

ISSN

0003-2999

Publication Date

August 1999

Volume

89

Issue

2

Start / End Page

290 / 295

Location

United States

Related Subject Headings

  • Vecuronium Bromide
  • Neuromuscular Nondepolarizing Agents
  • Middle Aged
  • Male
  • Humans
  • Histamine Release
  • Histamine
  • Hemodynamics
  • Heart Rate
  • Female