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Amrinone: its effect on vascular resistance and capacitance in human subjects.

Publication ,  Journal Article
Levy, JH; Bailey, JM
Published in: Chest
January 1994

Reports evaluating amrinone's effects in normal (intact) human subjects are complex and difficult to interpret because of the drug's diverse effects on myocardial function, resistance vessels, and vascular capacitance. In this study, 1.5 mg/kg of amrinone was administered as an intravenous bolus to cardiac surgical patients during constant flow cardiopulmonary bypass to determine its isolated effects on venous capacitance and vascular resistance. We noted a significant decrease in vascular resistance up to 8 min after injection and a 460 +/- 160 ml (mean +/- SD) decrease in venous reservoir volume 10 min after injection. Amrinone has potent venous and arterial vasodilating properties that make it a unique drug for treating congestive heart failure in addition to its reported positive inotropic effects.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

January 1994

Volume

105

Issue

1

Start / End Page

62 / 64

Location

United States

Related Subject Headings

  • Veins
  • Vasodilation
  • Vascular Resistance
  • Respiratory System
  • Humans
  • Heart Failure
  • Cardiopulmonary Bypass
  • Blood Volume
  • Blood Pressure
  • Blood Circulation
 

Citation

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Levy, J. H., & Bailey, J. M. (1994). Amrinone: its effect on vascular resistance and capacitance in human subjects. Chest, 105(1), 62–64. https://doi.org/10.1378/chest.105.1.62
Levy, J. H., and J. M. Bailey. “Amrinone: its effect on vascular resistance and capacitance in human subjects.Chest 105, no. 1 (January 1994): 62–64. https://doi.org/10.1378/chest.105.1.62.
Levy, J. H., and J. M. Bailey. “Amrinone: its effect on vascular resistance and capacitance in human subjects.Chest, vol. 105, no. 1, Jan. 1994, pp. 62–64. Pubmed, doi:10.1378/chest.105.1.62.
Levy JH, Bailey JM. Amrinone: its effect on vascular resistance and capacitance in human subjects. Chest. 1994 Jan;105(1):62–64.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

January 1994

Volume

105

Issue

1

Start / End Page

62 / 64

Location

United States

Related Subject Headings

  • Veins
  • Vasodilation
  • Vascular Resistance
  • Respiratory System
  • Humans
  • Heart Failure
  • Cardiopulmonary Bypass
  • Blood Volume
  • Blood Pressure
  • Blood Circulation