Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.
Publication
, Journal Article
Choi, BD; Suryadevara, CM; Gedeon, PC; Herndon, JE; Sanchez-Perez, L; Bigner, DD; Sampson, JH
Published in: J Clin Neurosci
January 2014
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.
Duke Scholars
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Published In
J Clin Neurosci
DOI
EISSN
1532-2653
Publication Date
January 2014
Volume
21
Issue
1
Start / End Page
189 / 190
Location
Scotland
Related Subject Headings
- Xenograft Model Antitumor Assays
- Transduction, Genetic
- Receptors, Antigen, T-Cell
- Neurology & Neurosurgery
- Mice, SCID
- Mice, Inbred NOD
- Mice
- Immunotherapy
- Humans
- Glioma
Citation
APA
Chicago
ICMJE
MLA
NLM
Choi, B. D., Suryadevara, C. M., Gedeon, P. C., Herndon, J. E., Sanchez-Perez, L., Bigner, D. D., & Sampson, J. H. (2014). Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. J Clin Neurosci, 21(1), 189–190. https://doi.org/10.1016/j.jocn.2013.03.012
Choi, Bryan D., Carter M. Suryadevara, Patrick C. Gedeon, James E. Herndon, Luis Sanchez-Perez, Darell D. Bigner, and John H. Sampson. “Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.” J Clin Neurosci 21, no. 1 (January 2014): 189–90. https://doi.org/10.1016/j.jocn.2013.03.012.
Choi BD, Suryadevara CM, Gedeon PC, Herndon JE, Sanchez-Perez L, Bigner DD, et al. Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. J Clin Neurosci. 2014 Jan;21(1):189–90.
Choi, Bryan D., et al. “Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.” J Clin Neurosci, vol. 21, no. 1, Jan. 2014, pp. 189–90. Pubmed, doi:10.1016/j.jocn.2013.03.012.
Choi BD, Suryadevara CM, Gedeon PC, Herndon JE, Sanchez-Perez L, Bigner DD, Sampson JH. Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma. J Clin Neurosci. 2014 Jan;21(1):189–190.
Published In
J Clin Neurosci
DOI
EISSN
1532-2653
Publication Date
January 2014
Volume
21
Issue
1
Start / End Page
189 / 190
Location
Scotland
Related Subject Headings
- Xenograft Model Antitumor Assays
- Transduction, Genetic
- Receptors, Antigen, T-Cell
- Neurology & Neurosurgery
- Mice, SCID
- Mice, Inbred NOD
- Mice
- Immunotherapy
- Humans
- Glioma