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Psyllium improves glycemic control in patients with type-2 diabetes mellitus

Publication ,  Journal Article
Feinglos, MN; Gibb, RD; Ramsey, DL; Surwit, RS; McRorie, JW
Published in: Bioactive Carbohydrates and Dietary Fibre
April 1, 2013

Objective: This double-blind, placebo-controlled clinical study was designed to evaluate the effects of psyllium on fasting blood glucose (FBG) and HbA1c in patients being treated for type-2 diabetes mellitus (T2DM). Research design and methods: Patients were randomly assigned to 1 of the 3 treatment groups: placebo, psyllium 3.4 g BID or psyllium 6.8 g BID (just prior to breakfast and dinner). Patients had a total of 9 clinic visits during the 20-week study period (8 weeks baseline, 12 weeks treatment). A total of 37 patients [12 females, 34 Caucasians, mean age 62 years] were enrolled (8 in the placebo group, 15 in the psyllium 3.4 g BID group and 14 in the psyllium 6.8 g BID group) and were included in the Intent-to-Treat analysis. Results: Both doses of psyllium significantly (p<0.05) lowered FBG compared to placebo at treatment weeks 4, 8, and 12. Psyllium 6.8 g BID significantly lowered HbA 1c compared to placebo at Week 8 (-0.58±0.18, p=0.003), and both the 3.4 g dose and the 6.8 g dose of psyllium significantly (p<0.05) lowered HbA1c compared to placebo at Week 12 (-0.53±0.20, p=0.013; -0.65±0.20, p=0.003, respectively). Conclusions: The improvement in glycemic control observed with psyllium in T2DM patients was above that already conferred by a restricted diet (all patients) and a stable dose of a sulfonylurea (81.1% of patients). These data support that psyllium is an effective co-therapy for improving glycemic control in patients being treated for T2DM. NCT01582282. © 2013 Elsevier Ltd.

Duke Scholars

Published In

Bioactive Carbohydrates and Dietary Fibre

DOI

ISSN

2212-6198

Publication Date

April 1, 2013

Volume

1

Issue

2

Start / End Page

156 / 161

Related Subject Headings

  • 3006 Food sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Feinglos, M. N., Gibb, R. D., Ramsey, D. L., Surwit, R. S., & McRorie, J. W. (2013). Psyllium improves glycemic control in patients with type-2 diabetes mellitus. Bioactive Carbohydrates and Dietary Fibre, 1(2), 156–161. https://doi.org/10.1016/j.bcdf.2013.02.003
Feinglos, M. N., R. D. Gibb, D. L. Ramsey, R. S. Surwit, and J. W. McRorie. “Psyllium improves glycemic control in patients with type-2 diabetes mellitus.” Bioactive Carbohydrates and Dietary Fibre 1, no. 2 (April 1, 2013): 156–61. https://doi.org/10.1016/j.bcdf.2013.02.003.
Feinglos MN, Gibb RD, Ramsey DL, Surwit RS, McRorie JW. Psyllium improves glycemic control in patients with type-2 diabetes mellitus. Bioactive Carbohydrates and Dietary Fibre. 2013 Apr 1;1(2):156–61.
Feinglos, M. N., et al. “Psyllium improves glycemic control in patients with type-2 diabetes mellitus.” Bioactive Carbohydrates and Dietary Fibre, vol. 1, no. 2, Apr. 2013, pp. 156–61. Scopus, doi:10.1016/j.bcdf.2013.02.003.
Feinglos MN, Gibb RD, Ramsey DL, Surwit RS, McRorie JW. Psyllium improves glycemic control in patients with type-2 diabetes mellitus. Bioactive Carbohydrates and Dietary Fibre. 2013 Apr 1;1(2):156–161.
Journal cover image

Published In

Bioactive Carbohydrates and Dietary Fibre

DOI

ISSN

2212-6198

Publication Date

April 1, 2013

Volume

1

Issue

2

Start / End Page

156 / 161

Related Subject Headings

  • 3006 Food sciences