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TRPV channels' role in osmotransduction and mechanotransduction.

Publication ,  Journal Article
Liedtke, W
Published in: Handb Exp Pharmacol
2007

In signal transduction of metazoan cells, transient receptor potential (TRP) ion channels have been identified that respond to diverse external and internal stimuli, among them osmotic and mechanical stimuli. This chapter will summarize findings on the TRPV subfamily, both its vertebrate and invertebrate members. Of the six mammalian TRPV channels, TRPV1, -V2, and -V4 were demonstrated to function in transduction of osmotic and/or mechanical stimuli. TRPV channels have been found to function in cellular as well as systemic osmotic homeostasis in vertebrates. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic stimuli in C. elegans. In a striking example of evolutionary conservation of function, mammalian TRPV4 has been found to rescue mechanosensory and osmosensory deficits of the TRPV mutant line osm-9 in C. elegans, despite no more than 26% orthology of the respective amino acid sequences.

Duke Scholars

Published In

Handb Exp Pharmacol

DOI

ISSN

0171-2004

Publication Date

2007

Issue

179

Start / End Page

473 / 487

Location

Germany

Related Subject Headings

  • Water-Electrolyte Balance
  • Transient Receptor Potential Channels
  • Tissue Culture Techniques
  • Signal Transduction
  • Mechanotransduction, Cellular
  • Humans
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals
 

Citation

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Liedtke, W. (2007). TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol, (179), 473–487. https://doi.org/10.1007/978-3-540-34891-7_28
Liedtke, W. “TRPV channels' role in osmotransduction and mechanotransduction.Handb Exp Pharmacol, no. 179 (2007): 473–87. https://doi.org/10.1007/978-3-540-34891-7_28.
Liedtke W. TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol. 2007;(179):473–87.
Liedtke, W. “TRPV channels' role in osmotransduction and mechanotransduction.Handb Exp Pharmacol, no. 179, 2007, pp. 473–87. Pubmed, doi:10.1007/978-3-540-34891-7_28.
Liedtke W. TRPV channels' role in osmotransduction and mechanotransduction. Handb Exp Pharmacol. 2007;(179):473–487.

Published In

Handb Exp Pharmacol

DOI

ISSN

0171-2004

Publication Date

2007

Issue

179

Start / End Page

473 / 487

Location

Germany

Related Subject Headings

  • Water-Electrolyte Balance
  • Transient Receptor Potential Channels
  • Tissue Culture Techniques
  • Signal Transduction
  • Mechanotransduction, Cellular
  • Humans
  • Caenorhabditis elegans Proteins
  • Caenorhabditis elegans
  • Animals