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Effect of maternal body mass index on the retinal microvasculature in pregnancy.

Publication ,  Journal Article
Li, L-J; Ikram, MK; Cheung, CY-L; Lee, Y-S; Lee, L-J; Gluckman, P; Godfrey, KM; Chong, Y-S; Kwek, K; Wong, T-Y; Saw, S-M
Published in: Obstet Gynecol
September 2012

OBJECTIVE: To estimate the effects of maternal body mass index (BMI) and pregnancy weight gain on the retinal microvasculature among pregnant women. METHODS: We studied 814 pregnant women aged 18-46 years who were recruited as part of the Growing Up in Singapore Toward Health Outcomes study, an ongoing birth cohort study from two government hospitals in Singapore since 2009. Recalled prepregnancy weight was recorded, and maternal anthropometric measurements of weight and height were performed at 26 weeks of gestation together with retinal photography. RESULTS: In multiple linear regression models, each standard deviation increase of 26-week pregnancy BMI (4.57) was associated with narrower retinal arteriolar caliber (by 1.58 micrometers, P<.001), wider venular caliber (by 1.28 micrometers, P=.02), and increased retinal venular tortuosity (P=.01). Compared with mothers with normal weight, obese mothers (prepregnancy BMI greater than 30.0) had narrower retinal arteriolar caliber (118.81 compared with 123.38 micrometers, P<.001), wider retinal venular caliber (175.81 compared with 173.01 micrometers; P<.01), and increased retinal venular tortuosity (129.92 compared with 121.49 × 10(-6); P<.01). Pregnant women whose BMI-specific weight gain from prepregnancy to 26 weeks of gestation was above Institute of Medicine recommendations had narrower retinal arteriolar caliber (120.68 micrometers) than women with ideal (121.91 micrometers) and less than ideal weight gain (123.17), respectively (P trend=.05). CONCLUSION: These data indicate that greater prepregnancy BMI and pregnancy BMI are associated with adverse retinal microvascular measures, suggesting that maternal obesity has an effect on her microcirculation.

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Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2012

Volume

120

Issue

3

Start / End Page

627 / 635

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Gain
  • Singapore
  • Retinal Vessels
  • Pregnancy Complications
  • Pregnancy
  • Photography
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
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Li, L.-J., Ikram, M. K., Cheung, C.-L., Lee, Y.-S., Lee, L.-J., Gluckman, P., … Saw, S.-M. (2012). Effect of maternal body mass index on the retinal microvasculature in pregnancy. Obstet Gynecol, 120(3), 627–635. https://doi.org/10.1097/AOG.0b013e3182639577
Li, Ling-Jun, M Kamran Ikram, Carol Yim-Lui Cheung, Yung-Seng Lee, Lin-Jun Lee, Peter Gluckman, Keith M. Godfrey, et al. “Effect of maternal body mass index on the retinal microvasculature in pregnancy.Obstet Gynecol 120, no. 3 (September 2012): 627–35. https://doi.org/10.1097/AOG.0b013e3182639577.
Li L-J, Ikram MK, Cheung CY-L, Lee Y-S, Lee L-J, Gluckman P, et al. Effect of maternal body mass index on the retinal microvasculature in pregnancy. Obstet Gynecol. 2012 Sep;120(3):627–35.
Li, Ling-Jun, et al. “Effect of maternal body mass index on the retinal microvasculature in pregnancy.Obstet Gynecol, vol. 120, no. 3, Sept. 2012, pp. 627–35. Pubmed, doi:10.1097/AOG.0b013e3182639577.
Li L-J, Ikram MK, Cheung CY-L, Lee Y-S, Lee L-J, Gluckman P, Godfrey KM, Chong Y-S, Kwek K, Wong T-Y, Saw S-M. Effect of maternal body mass index on the retinal microvasculature in pregnancy. Obstet Gynecol. 2012 Sep;120(3):627–635.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

September 2012

Volume

120

Issue

3

Start / End Page

627 / 635

Location

United States

Related Subject Headings

  • Young Adult
  • Weight Gain
  • Singapore
  • Retinal Vessels
  • Pregnancy Complications
  • Pregnancy
  • Photography
  • Obstetrics & Reproductive Medicine
  • Obesity
  • Middle Aged