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Relationship of ocular biometry and retinal vascular caliber in preschoolers.

Publication ,  Journal Article
Li, L-J; Cheung, CY-L; Gazzard, G; Chang, L; Mitchell, P; Wong, T-Y; Saw, S-M
Published in: Invest Ophthalmol Vis Sci
December 20, 2011

PURPOSE: To systematically examine the association between ocular biometry and retinal vascular caliber in Singapore Chinese preschoolers aged 48 to 72 months. METHODS: A total of 469 Singapore Chinese children aged 48 to 72 months were recruited through the Strabismus, Amblyopia and Refractive Error Study in Singaporean Chinese Preschoolers (STARS) from 2006 to 2008. According to standardized protocols, cycloplegic autorefraction, ocular biometry measurements, and retinal photography were performed. Retinal vascular caliber was measured quantitatively and was summarized as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE), respectively. Ocular magnification was corrected by using the Bengtsson formula. RESULTS: The mean retinal arteriolar and venular calibers were 156.08 μm and 219.55 μm in boys, and 161.96 μm and 224.25 μm in girls, respectively. In multiple linear regression adjusted for age, sex, father's education, parental myopia history, mean arterial blood pressure, body mass index, and spherical equivalent, each 1.0 mm increase in axial length was associated with a 3.52 μm decrease in retinal arteriolar caliber (P = 0.023) and a 5.55 μm decrease in retinal venular caliber (P = 0.008). Each 1.00 mm increase in corneal curvature was associated with a 13.79 μm decrease (P = 0.004) in retinal venular caliber. CONCLUSIONS: In very young children aged 48 to 72 months, narrower retinal arteriolar and venular caliber was associated with elongated axial length. Narrower retinal venular caliber was associated with larger corneal curvature. This suggests that the major structural correlate of myopia might have an effect on retinal microvasculature from early childhood.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 20, 2011

Volume

52

Issue

13

Start / End Page

9561 / 9566

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Vein
  • Retinal Artery
  • Refraction, Ocular
  • Photography
  • Ophthalmology & Optometry
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, L.-J., Cheung, C.-L., Gazzard, G., Chang, L., Mitchell, P., Wong, T.-Y., & Saw, S.-M. (2011). Relationship of ocular biometry and retinal vascular caliber in preschoolers. Invest Ophthalmol Vis Sci, 52(13), 9561–9566. https://doi.org/10.1167/iovs.11-7969
Li, Ling-Jun, Carol Yim-Lui Cheung, Gus Gazzard, Lan Chang, Paul Mitchell, Tien-Yin Wong, and Seang-Mei Saw. “Relationship of ocular biometry and retinal vascular caliber in preschoolers.Invest Ophthalmol Vis Sci 52, no. 13 (December 20, 2011): 9561–66. https://doi.org/10.1167/iovs.11-7969.
Li L-J, Cheung CY-L, Gazzard G, Chang L, Mitchell P, Wong T-Y, et al. Relationship of ocular biometry and retinal vascular caliber in preschoolers. Invest Ophthalmol Vis Sci. 2011 Dec 20;52(13):9561–6.
Li, Ling-Jun, et al. “Relationship of ocular biometry and retinal vascular caliber in preschoolers.Invest Ophthalmol Vis Sci, vol. 52, no. 13, Dec. 2011, pp. 9561–66. Pubmed, doi:10.1167/iovs.11-7969.
Li L-J, Cheung CY-L, Gazzard G, Chang L, Mitchell P, Wong T-Y, Saw S-M. Relationship of ocular biometry and retinal vascular caliber in preschoolers. Invest Ophthalmol Vis Sci. 2011 Dec 20;52(13):9561–9566.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 20, 2011

Volume

52

Issue

13

Start / End Page

9561 / 9566

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Vein
  • Retinal Artery
  • Refraction, Ocular
  • Photography
  • Ophthalmology & Optometry
  • Male
  • Humans
  • Female
  • Cross-Sectional Studies