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Menorrhagia in patients with type I glycogen storage disease.

Publication ,  Journal Article
Austin, SL; El-Gharbawy, AH; Kasturi, VG; James, A; Kishnani, PS
Published in: Obstet Gynecol
December 2013

OBJECTIVE: To evaluate menorrhagia in a cohort of women with glycogen storage disease type I because it appears to be an under-recognized problem in females of reproductive age. METHODS: A retrospective chart review was performed on 13 menstruating patients with glycogen storage disease type I (age 23-48 years) for a diagnosis of menorrhagia. RESULTS: Nine (69%) (confidence interval 0.39-0.91) women had development of menorrhagia. Median hemoglobin values in these patients were generally low (range 9.5-12.85 g/dL) but not different from those of the nonmenorrhagia group (hemoglobin range 9.55-11.0 g/dL) with glycogen storage disease type I. Four patients with menorrhagia required hospitalization or emergency department visits for treatment of menorrhagia. Two of the four patients hospitalized required blood transfusion, with an additional patient requiring a transfusion during pregnancy. Eight patients (89%) either were recommended to have or required medical or surgical treatment of their menorrhagia. CONCLUSION: Glycogen storage disease type I is associated with menorrhagia. The evaluation should include assessment of coagulation functions and referral to a gynecologist, hematologist, or both, because bleeding diathesis and polycystic ovary syndrome are common in patients with glycogen storage disease type I.

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Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

December 2013

Volume

122

Issue

6

Start / End Page

1246 / 1254

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Young Adult
  • Retrospective Studies
  • Platelet Aggregation
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menorrhagia
  • Liver Neoplasms
  • Lactic Acid
  • Hyperlipidemias
 

Citation

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Austin, S. L., El-Gharbawy, A. H., Kasturi, V. G., James, A., & Kishnani, P. S. (2013). Menorrhagia in patients with type I glycogen storage disease. Obstet Gynecol, 122(6), 1246–1254. https://doi.org/10.1097/01.AOG.0000435451.86108.82
Austin, Stephanie L., Areeg H. El-Gharbawy, Vellore G. Kasturi, Andra James, and Priya S. Kishnani. “Menorrhagia in patients with type I glycogen storage disease.Obstet Gynecol 122, no. 6 (December 2013): 1246–54. https://doi.org/10.1097/01.AOG.0000435451.86108.82.
Austin SL, El-Gharbawy AH, Kasturi VG, James A, Kishnani PS. Menorrhagia in patients with type I glycogen storage disease. Obstet Gynecol. 2013 Dec;122(6):1246–54.
Austin, Stephanie L., et al. “Menorrhagia in patients with type I glycogen storage disease.Obstet Gynecol, vol. 122, no. 6, Dec. 2013, pp. 1246–54. Pubmed, doi:10.1097/01.AOG.0000435451.86108.82.
Austin SL, El-Gharbawy AH, Kasturi VG, James A, Kishnani PS. Menorrhagia in patients with type I glycogen storage disease. Obstet Gynecol. 2013 Dec;122(6):1246–1254.

Published In

Obstet Gynecol

DOI

EISSN

1873-233X

Publication Date

December 2013

Volume

122

Issue

6

Start / End Page

1246 / 1254

Location

United States

Related Subject Headings

  • von Willebrand Factor
  • Young Adult
  • Retrospective Studies
  • Platelet Aggregation
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menorrhagia
  • Liver Neoplasms
  • Lactic Acid
  • Hyperlipidemias