Overview
My primary research areas include statistical genetics and the genetic investigation of human complex diseases and clinical outcomes. As the group leader of the Biostatistics and Clinical Outcome Group in the Department of Anesthesiology, I also have extensive experience in clinical research, applying both classical statistical modeling and modern machine learning methods to analyze clinical data. Below is a list of my research topics:"
- Statistical genetics: development statistical methods for different genetic data and phenotypic measures
- Genetics of Alzheimer's disease (AD) and age-at-onset (AAO) of AD
- Genetics of Fuchs endothelial corneal dystrophy (FECD)
- Genetic and HLA association for drug induced liver injury (DILI)
- Genetic and clinical research of postoperative outcomes, such as postoperative acute kidney injury, cognitive dysfunction, delirium, etc.
- Biomarker research for osteoarthritis (OA) and its progression
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
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2021 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Member of Duke Molecular Physiology Institute
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2014 - Present
Duke Molecular Physiology Institute,
Institutes and Centers
Recent Publications
Treating Malignant Hypertension With the Low-Sodium, Low-Protein, and Low-Fat Rice Diet.
Journal Article Hypertension · January 2026 BACKGROUND: The rice diet (RD), a low-sodium (<200 mg/d), low-protein (≈20 g/d), and low-fat (<5 g/d) diet was used to treat patients with malignant hypertension beginning in the 1940s, before any effective antihypertensive drugs were available. We retrosp ... Full text Open Access Link to item CiteClinical and Genetic Associations in Cephalosporin-Induced Liver Injury: Insights From the Drug-Induced Liver Injury Network.
Journal Article Aliment Pharmacol Ther · November 2025 INTRODUCTION: Cephalosporins are widely prescribed antibiotics due to their efficacy and safety. Although rare, idiosyncratic drug-induced liver injury (DILI) has been reported with their use. Here, we characterise the clinical features and HLA association ... Full text Link to item CiteEditorial: Cephalosporin-Induced Liver Injury-Interesting but Tricky. Authors' Reply.
Journal Article Aliment Pharmacol Ther · November 2025 Full text Link to item CiteRecent Grants
Drug Induced Liver Injury Network Data Coordinating Center
ResearchCo Investigator · Awarded by National Institutes of Health · 2003 - 2028Proteomic Biomarkers Predicting Osteoarthritis Onset and Progression
ResearchCo Investigator · Awarded by Department of Defense · 2025 - 2027Neurocognition & Greater Maintenance of Sinus Rhythm in AF (NOGGIN AF)
Clinical TrialBiostatistician · Awarded by National Institute on Aging · 2021 - 2026View All Grants