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Christoph Paul Vincent Hornik

Samuel L. Katz Distinguished Professor of Pediatrics
Pediatrics, Critical Care Medicine
DCRI PO Box 17969, Durham, NC 27715
Dept of Pediatrics, Durham, NC 27710

Current Appointments & Affiliations


Samuel L. Katz Distinguished Professor of Pediatrics · 2024 - Present Pediatrics, Critical Care Medicine, Pediatrics
Professor of Pediatrics · 2023 - Present Pediatrics, Critical Care Medicine, Pediatrics
Chief, Division of Quantitative Sciences · 2018 - Present Pediatrics, Clinical Science Departments
Vice-Chair for Research in the Department of Pediatrics · 2022 - Present Pediatrics, Clinical Science Departments
Membership in the Duke Clinical Research Institute · 2013 - Present Duke Clinical Research Institute, Institutes and Centers

In the News


Published March 19, 2024
Duke Awards 32 New Distinguished Professorships for 2024
Published October 7, 2022
New DCRI Center Targets Ending Opioid Addiction
Published September 16, 2022
No More Guessing on the Right Dosage for Children

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Recent Publications


Training the Next Generation of Pediatric Clinical Pharmacologists: Insights and Trainee Perspectives Over 10 Years.

Journal Article J Clin Pharmacol · March 2025 The limited number of researchers with expertise necessary toaddress treatment gaps for children presents an ongoing challenge. The NationalInstitutes of Health established a national Pediatric Clinical Pharmacology T32Training Program in 2012 to train a m ... Full text Link to item Cite

Opioid use in treated and untreated obstructive sleep apnoea: remifentanil pharmacokinetics and pharmacodynamics in adult volunteers.

Journal Article Br J Anaesth · March 2025 BACKGROUND: Patients with obstructive sleep apnoea (OSA) are considered more sensitive to opioids and at increased risk of opioid-induced respiratory depression. Nonetheless, whether OSA treatment (continuous positive airway pressure, CPAP; or bilevel posi ... Full text Link to item Cite

Population Pharmacokinetics of Caffeine in Infants with Hypoxic-Ischemic Encephalopathy: A Phase I, Dose-Escalating Trial.

Journal Article J Clin Pharmacol · February 12, 2025 The mainstay of treatment for infants with hypoxic-ischemic encephalopathy (HIE) is cooling. Caffeine may be an important adjunct to cooling and provide neuroprotection via its anti-inflammatory and anti-oxidative properties. This study aimed to characteri ... Full text Link to item Cite
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Recent Grants


Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

Real-world Data Enables Pharmacokinetic/Pharmacodynamic Drug Dosing in Critically Ill Children

ResearchMentor · Awarded by National Institutes of Health · 2025 - 2029

DCRI D-COHRe Partnership for Innovation, Improved Access, and Operational Capability for Decentralized Clinical Trials of Medical Countermeasures in Public Health Emergencies

ResearchPrincipal Investigator · Awarded by Biomedical Advanced Research and Development Authority · 2024 - 2029

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Education, Training & Certifications


University of North Carolina, Chapel Hill · 2019 Ph.D.
University of North Carolina, Chapel Hill · 2012 M.P.H.
Albert Ludwigs University of Freiburg (Germany) · 2005 M.D.