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Christoph Paul Vincent Hornik

Samuel L. Katz Distinguished Professor of Pediatrics
Pediatrics, Critical Care Medicine
DCRI PO Box 17969, Durham, NC 27715
Dept of Pediatrics, Durham, NC 27710

Research Interests


Clinical Research Innovation

Selected Grants


Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

Mentoring in Pediatric Cardiovascular Pharmacology and Early Phase Trials

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028

CPCCRN

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

Duke University Maternal-Fetal Medicine Units (MFMU) Network Clinical Center

ResearchCollaborating Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023 - 2030

Mentoring in Pediatric Cardiovascular Pharmacology and Early Phase Trials

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028

CPCCRN

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

Personalized Immunomodulation in Pediatric Sepsis-Induced MODS (PRECISE) (CPCCRN)

ResearchPrincipal Investigator · Awarded by University of Utah · 2021 - 2026

Deep learning artificial intelligence detection of pediatric heart transplant rejection

ResearchMentor · Awarded by Thrasher Research Fund · 2024 - 2026

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2016 - 2026

Pediatric Trials Network_ Task Order 1_ Core Function Activities

ResearchCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2018 - 2026

Duke-UNC Collaborative Pediatric Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2021 - 2026

Digoxin Pharmacodynamics in Infants with Heart Failure due to Single Ventricle Congenital Heart Disease

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2026

PTN 2.0 TO #10: Positron-C

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2025

Real World Data to Support Pediatric Drug Labeling

ResearchPrincipal Investigator · Awarded by Burroughs Wellcome Fund · 2019 - 2025

Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary Dysplasia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2025

Spoonfulone

ResearchPrincipal Investigator · Awarded by Before Brands, Inc. · 2020 - 2024

A Phase 1 Study of AAV8-LSPhGAA (ACTUS-101) in Late-Onset Pompe Disease

Clinical TrialPrincipal Investigator · Awarded by Actus Therapeutics · 2018 - 2024

You and Me Healthy: Testing Protocol

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

Duke Summer Training in Academic Research (Duke's STAR)

ResearchMentor · Awarded by National Institutes of Health · 2018 - 2024

Evaluating Sertraline Exposure in Breastmilk using Novel Collection Methods

ResearchPrincipal Investigator · Awarded by The Trustees of Indiana University · 2023 - 2024

Optimizing caffeine exposure to reduce post-cardiopulmonary bypass acute kidney injury in neonates

ResearchCo-Mentor · Awarded by Thrasher Research Fund · 2022 - 2023

Optimizing Hydroxychloroquine to Reduce Disease Activity in Pediatric Lupus

ResearchCo-Mentor · Awarded by Thrasher Research Fund · 2021 - 2023

Global Pediatric Clinical Trials Network

ResearchPrincipal Investigator · Awarded by Food and Drug Administration · 2017 - 2023

PTN2- TO# BPCA Pharmacology Studies

ResearchCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2018 - 2023

PTN 2.0 TO1 Core Function Activities - Option 4

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2022 - 2023

Oxycontin Peds Study (EPM 7254)

ResearchPrincipal Investigator · Awarded by Purdue Pharma · 2021 - 2022

Perioperative Tissue Penetration of Antimicrobials in Infants

ResearchPrincipal Investigator · Awarded by Thrasher Research Fund · 2020 - 2022

Pediatric Critical Care Research Landscape - A National Expert Conference

ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022

PTN 2.0- TO 3 - Option 3 - BPCA Concept Development and Clinical Trial Readiness Support

ResearchPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2021 - 2022

PTN 2.0 TO 1 Core Function Activities_Option 3

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021 - 2022

R21 ICT Tools for Rare Diseases

ResearchPrincipal Investigator · Awarded by Research Triangle Institute International · 2019 - 2021

PTN 2.0- TO 3 - Option 2 - BPCA Concept Development and Clinical Trial Readiness Support

ResearchPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2020 - 2021

Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary Dysplasia

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

PTN 2.0 TO 1 Core Function Activities_Option 2

Clinical TrialCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2020 - 2021

PMR 292932: A Nationally Representative Drug Utilization Study of OxyContin in Children Aged 17 Years and Younger

Clinical TrialPrincipal Investigator · Awarded by Purdue Pharma · 2018 - 2021

Pharmacokinetics, Pharmacodynamics, and Safety of Methylprednisolone in Neonates on Cardiopulmonary Bypass

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2020

PTN2- TO# 3 Concept Development and Clinical Trial Readiness Support Option Period 1

ResearchPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2019 - 2020

A Phase I Study of the Safety of AAV2/8 LSPhGAA in Late-onset Pompe Disease

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2017 - 2020

Pediatric Trials Network_ Task Order 1_ Core Function Activities Option Period 1

ResearchCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2019 - 2020

PTN2- TO# BPCA Concept Development and Clinical Trial Readiness Support

ResearchPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2018 - 2019

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2017 - 2019

Echocardiogram to Diagnose Pulmonary Hypertension in Premature Infants

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2015 - 2019

SOLI - Solithromycin Pediatric Development Program (Phase 2/3)- Labor & Sub Cost

Clinical TrialStatistical Investigator · Awarded by Cempra Pharmaceuticals, Inc. · 2016 - 2018

PTN Task Order 36- PTN Repository: Modification 1

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018

PTN TO #39: PPE

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018

PTN TO #34: Program Management Support - Option 2

Clinical TrialCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2017 - 2018

PTN TO#47 (Protocol Development V)

ResearchCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2017 - 2018

Linking Safety Practices to Adverse Events and Outcomes in Hospitalized Infants

ResearchCo Investigator · Awarded by National Institutes of Health · 2015 - 2018

PTN TO#36 - PTN Repository

ResearchPrincipal Investigator · Awarded by National Institute for Child Health & Human Develo · 2015 - 2017

PTN TO#40 (Protocol Development IV)

ResearchCo Investigator · Awarded by National Institute for Child Health & Human Develo · 2015 - 2016

CISA TO2 Prophylactic Antipyretics Revision 1-A

ResearchInvestigator · Awarded by Centers for Disease Control and Prevention · 2014 - 2016

CISA TO2 Prophylactic Antipyretics Revision 3-A

ResearchInvestigator · Awarded by Centers for Disease Control and Prevention · 2014 - 2016

CISA TO2 Prophylactic Antipyretics

ResearchCo Investigator · Awarded by Centers for Disease Control and Prevention · 2013 - 2016

PTN Task Order--Protocol Development III

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2014 - 2015

External Relationships


  • Cytokinetics, Inc.
  • Lightship
  • SC Pharma
  • Tellus Therapeutics, Inc.
  • UCB Pharma

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.