Overview
I am a cardiologist with a clinical and research interest in heart failure (going from Failure to Function), including advanced therapies such as cardiac transplantation and mechanical assist devices or “heart pumps."
I serve our group as Chief of the Heart Failure Section.
I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.
I am the Editor in Chief of the Journal of Cardiac Failure - The official journal of the Heart Failure Society of America.
My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:
I serve our group as Chief of the Heart Failure Section.
I became a heart failure cardiologist in order to help patients manage their chronic disease over many months and years. I consider myself strongly committed to compassionate patient care with a focus on quality of life and patient preference.
I am the Editor in Chief of the Journal of Cardiac Failure - The official journal of the Heart Failure Society of America.
My research interests are focused on treating co-morbid diseases in heart failure patients and improving outcomes across the cardiovascular spectrum through clinical trials and outcomes research. Below, you will find my specific research interests:
- Cardiometabolic disease
- Co-morbidity characterization (diabetes, sleep apnea, renal failure) in heart failure
- Phenotypic characterization and risk prognostication of patients with heart failure
- Role of surrogate and nonfatal endpoints in clinical heart failure trials
- Biomarkers in heart failure
- Novel pharmacological and non-pharmacological approaches to heart failure
- Improving site-based heart failure research
Current Appointments & Affiliations
Associate Professor of Medicine
·
2023 - Present
Medicine, Cardiology,
Medicine
Associate Professor in Population Health Sciences
·
2020 - Present
Population Health Sciences,
Basic Science Departments
Member in the Duke Clinical Research Institute
·
2014 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Circulating Biomarkers as Predictors of Improvement in Physical Function in Hospitalized Older Adults With Geriatric Syndromes: Findings From the REHAB-HF Trial.
Journal Article Circ Heart Fail · January 7, 2026 BACKGROUND: Biomarkers in heart failure (HF) provide mechanistic and prognostic insights, but their role in predicting treatment response is less understood. We evaluated whether multiple baseline biomarker profiles from the REHAB-HF trial (Rehabilitation ... Full text Link to item CiteAngiotensin-neprilysin inhibition in acute decompensated heart failure: a meta-analysis of randomized controlled trials.
Journal Article Future Cardiol · January 2026 BACKGROUND: Angiotensin receptor - neprilysin inhibitors (ARNI) are well-established for chronic heart failure (HF) with reduced ejection fraction. However, their efficacy and safety after stabilization of acute decompensation (ADHF) remain unclear. This m ... Full text Link to item CiteEfficacy of cardiac myosin activators compared to placebo in patients with heart failure and reduced ejection fraction: A systematic review and meta-analysis of randomized controlled trials.
Journal Article Heart Lung · 2026 BACKGROUND: Cardiac myosin activators (CMAs) have been explored as a potential therapy to enhance cardiac contractility in patients with heart failure with reduced ejection fraction (HFrEF). However, their effect on clinical outcomes, including mortality, ... Full text Link to item CiteRecent Grants
Safety and Efficacy of the Alleviant No-Implant Interatrial Shunt in Patients with Heart Failure and Reduced Ejection Fraction
Clinical TrialPrincipal Investigator · Awarded by Alleviant Medical, Inc. · 2025 - 2032Research Triangle Center of Excellence in Regulatory Science and Innovation
ResearchCo-Principal Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028Journal of Cardiac Failure
Public ServicePrincipal Investigator · Awarded by Heart Failure Society of America · 2021 - 2027View All Grants
Education, Training & Certifications
Emory University ·
2003
M.D.