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Robert John Mentz

Associate Professor of Medicine
Medicine, Cardiology
NP-8062, DCRI. PO Box 17969, Durham, NC 27715
NP-8062, DCRI. PO Box 17969, Durham, NC 27715

Research Interests


  • Clinical trials in heart failure
  • Co-morbidity characterization (diabetes, lung disease, sleep apnea, renal failure) in heart failure.
  • Phenotypic characterization and risk prognostication of patients with heart failure.
  • Role of surrogate and nonfatal endpoints (e.g., dyspnea) in clinical heart failure trials.
  • Biomarkers in heart failure.
  • Novel pharmacological and non-pharmacological approaches to heart failure.
  • Improving site-based heart failure research.

Selected Grants


Research Triangle Center of Excellence in Regulatory Science and Innovation

ResearchCo-Principal Investigator · Awarded by University of North Carolina - Chapel Hill · 2023 - 2028

BalanceD-HF

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca UK Limited · 2024 - 2027

Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial - Trial Administration

ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2022 - 2027

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2016 - 2026

Journal of Cardiac Failure

Public ServicePrincipal Investigator · Awarded by Heart Failure Society of America · 2021 - 2025

Development and Validation of Advanced Heart Failure Computable Phenotypes

ResearchPrincipal Investigator · Awarded by Mayo Clinic - Rochester · 2023 - 2025

Postdoctoral Training in Cardiovascular Clinical Research

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2025

Exscel Biomarker Analysis and Secondary Manuscript Production

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca Pharmaceuticals, LP · 2020 - 2024

PROSPective evaluation of Eggland's Best Related to Improvement in The biomarker profile for Your health

Clinical TrialPrincipal Investigator · Awarded by Eggland's Best, LLC · 2020 - 2024

Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage

ResearchCo Investigator · Awarded by University of Mississippi Medical Center · 2022 - 2023

Health Economics and Outcomes Research Collaboration

ResearchPrincipal Investigator · Awarded by Cytokinetics, Inc. · 2020 - 2023

New Advances in HFrEF: Learning Lab

Inst. Training Prgm or CMEPrincipal Investigator · Awarded by Cytokinetics, Inc. · 2022 - 2023

Evaluating Population-Level Disparities in Cardiovascular Disease Progression: A Structural Equation Modeling Approach

FellowshipPrincipal Investigator · Awarded by American Heart Association · 2022 - 2022

Prognostic value of Heart Rate Variability measured by Cardiovascular Implantable Electronic Devices

ResearchPrincipal Investigator · Awarded by Bayer Pharmaceuticals · 2020 - 2022

VICTORIA Registry

ResearchPrincipal Investigator · Awarded by Merck · 2017 - 2022

Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage

ResearchCo Investigator · Awarded by University of Mississippi Medical Center · 2021 - 2022

Development and Validation of Advanced Heart Failure Computable Phenotypes

ResearchPrincipal Investigator · Awarded by Mayo Clinic - Rochester · 2022 - 2022

TRANSFORM-HF CCC

Clinical TrialCo Investigator · Awarded by National Institutes of Health · 2017 - 2022

BAY 2413555 in pts w HF and ICD

ResearchPrincipal Investigator · Awarded by Bayer HealthCare AG · 2021 - 2022

Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage

ResearchCo Investigator · Awarded by University of Mississippi Medical Center · 2020 - 2021

UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program

Inst. Training Prgm or CMEMentor · Awarded by University of North Carolina - Chapel Hill · 2020 - 2021

Target-HF-CM

Clinical TrialPrincipal Investigator · Awarded by American Heart Association · 2017 - 2021

REHAB: A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients

Clinical TrialPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2014 - 2021

JTT-251_HF Trial

Clinical TrialPrincipal Investigator · Awarded by Akros Medical · 2017 - 2020

Jackson Heart Study Cardiovascular Disease (CVD) Working Group and Medicare Data Linkage

ResearchCo Investigator · Awarded by University of Mississippi Medical Center · 2019 - 2020

PROVIDE-HF: Patient Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (Valsartan/Sacubitril) in Heart Failure.

Clinical TrialPrincipal Investigator · Awarded by Novartis Pharmaceuticals Corporation · 2017 - 2020

Comparison of Dyspnea Measurement Instruments in Acute Heart Failure

Clinical TrialSenior Investigator · Awarded by Heart Failure Society of America · 2017 - 2019

Depression and Heart Failure Disease Progression

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2019

Accrelerometry Substudy

ResearchPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2017 - 2019

Define-HF

Clinical TrialPrincipal Investigator · Awarded by Saint Luke's Hospital (Kansas City) · 2016 - 2019

Subcutaneous Furosemide in Acute Decompensated Heart Failure

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2018

Sub Q

Clinical TrialPrincipal Investigator · Awarded by National Institutes of Health · 2016 - 2018

Characterizing HIV-related Diastolic Dysfunction

Clinical TrialPrincipal Investigator · Awarded by National Heart, Lung, and Blood Institute · 2016 - 2018

Accelerometer Data Collection and Analysis of REHAB-HF Participants

Clinical TrialPrincipal Investigator · Awarded by Wake Forest University Health Sciences · 2015 - 2018

A Collaboration for Improving Outcomes of African Americans with Heart Failure

ResearchCo Investigator · Awarded by National Institutes of Health · 2013 - 2018

Angina Pectoris in Diabetic Patients

ResearchPrincipal Investigator · Awarded by Gilead Sciences, Inc. · 2014 - 2018

Cardiac Outcomes Risk Assessment (CORA)

ResearchCo Investigator · Awarded by Carnegie Mellon University · 2015 - 2017

Palliative Care in Heart Failure (PAL-HF)

Clinical TrialResearch Assistant · Awarded by National Institutes of Health · 2011 - 2016

Cardiovascular Improvements with Minute Ventilation-targeted ASV Therapy in Heart Failure

Clinical TrialPrincipal Investigator · Awarded by ResMed Corp · 2013 - 2016

External Relationships


  • Abbott (St. Jude Medical)
  • Alleviant Medical
  • Amgen
  • AstraZeneca
  • Bayer
  • Boehringer Ingleheim
  • Lilly
  • Medtronic (Covidien)
  • Merck
  • Novartis
  • Novo Nordisk
  • Pharmacosmos
  • Respicardia
  • Rocket Pharma
  • Windtree Therapeutics, Inc.
  • american regent
  • innolife
  • vifor

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.