New applications of disease genetics and pharmacogenetics to drug development.

Published

Journal Article (Review)

TOMMORROW is a Phase III delay of onset clinical trial to determine whether low doses of pioglitazone, a molecule that induces mitochondrial doubling, delays the onset of MCI-AD in normal subjects treated with low dose compared to placebo. BOLD imaging studies in rodents and man were used to find the dose that increases oxygen consumption at central regions of the brain in higher proportion than activation of large corticol regions. The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period.

Full Text

Duke Authors

Cited Authors

  • Roses, AD; Saunders, AM; Lutz, MW; Zhang, N; Hariri, AR; Asin, KE; Crenshaw, DG; Budur, K; Burns, DK; Brannan, SK

Published Date

  • February 2014

Published In

Volume / Issue

  • 14 /

Start / End Page

  • 81 - 89

PubMed ID

  • 24565016

Pubmed Central ID

  • 24565016

Electronic International Standard Serial Number (EISSN)

  • 1471-4973

International Standard Serial Number (ISSN)

  • 1471-4892

Digital Object Identifier (DOI)

  • 10.1016/j.coph.2013.12.002

Language

  • eng