Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen.

Journal Article (Journal Article)

The role of the circulating renin-angiotensin system (RAS) in regulating systemic blood pressure and sodium balance is well established. More recently, researchers have turned their focus to the local generation of angiotensin II (Ang II) in specific tissues. Matsusaka et al. revisit the renal RAS and provide evidence that liver-derived angiotensinogen (AGT) is a major determinant of renal Ang II levels in a model of podocyte injury.

Full Text

Duke Authors

Cited Authors

  • Ortiz-Melo, DI; Spurney, RF

Published Date

  • May 2014

Published In

Volume / Issue

  • 85 / 5

Start / End Page

  • 1009 - 1011

PubMed ID

  • 24786873

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1038/ki.2013.440


  • eng

Conference Location

  • United States