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Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.

Publication ,  Journal Article
Magaziner, JS; Orwig, DL; Lyles, KW; Nordsletten, L; Boonen, S; Adachi, JD; Recknor, C; Colón-Emeric, CS; Mesenbrink, P; Bucci-Rechtweg, C ...
Published in: J Bone Miner Res
December 2014

Minimizing post-fracture bone loss is an important aspect of recovery from hip fracture, and determination of factors that affect bone mineral density (BMD) response to treatment after hip fracture may assist in the development of targeted therapeutic interventions. A post hoc analysis of the HORIZON Recurrent Fracture Trial was done to determine the effect of zoledronic acid (ZOL) on total hip (TH) and femoral neck (FN) BMD in subgroups with low-trauma hip fracture. A total of 2127 patients were randomized (1:1) to yearly infusions of ZOL 5 mg (n = 1065) or placebo (n = 1062) within 90 days of operation for low-trauma hip fracture. The 1486 patients with a baseline and at least one post-baseline BMD assessment at TH or FN (ZOL = 745, placebo = 741) were included in the analyses. Percentage change from baseline in TH and FN BMD was assessed at months 12 and 24 and compared across subgroups of hip fracture patients. Percentage change from baseline in TH and FN BMD at months 12 and 24 was greater (p < 0.05) in ZOL-treated patients compared with placebo in most subgroups. Treatment-by-subgroup interactions (p < 0.05) indicated that a greater effect on BMD was observed for TH BMD at month 12 in females, in patients in the lower tertile body mass index at baseline (≤22.6 kg/m(2) ), and in patients with baseline FN BMD T-score of ≤ -2.5; for FN BMD in patients who received ZOL for >6 weeks post-surgery; and for TH and FN BMD in patients with a history of one or more prior fractures. All interactions were limited to the first 12 months after treatment with none observed for the 24-month comparisons. (Clinical trial registration number NCT00046254.)

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Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

December 2014

Volume

29

Issue

12

Start / End Page

2545 / 2551

Location

England

Related Subject Headings

  • Zoledronic Acid
  • Sex Factors
  • Middle Aged
  • Male
  • Imidazoles
  • Humans
  • Hip Fractures
  • Follow-Up Studies
  • Female
  • Double-Blind Method
 

Citation

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Magaziner, J. S., Orwig, D. L., Lyles, K. W., Nordsletten, L., Boonen, S., Adachi, J. D., … Pieper, C. F. (2014). Subgroup variations in bone mineral density response to zoledronic acid after hip fracture. J Bone Miner Res, 29(12), 2545–2551. https://doi.org/10.1002/jbmr.2283
Magaziner, Jay S., Denise L. Orwig, Kenneth W. Lyles, Lars Nordsletten, Steven Boonen, Jonathan D. Adachi, Chris Recknor, et al. “Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.J Bone Miner Res 29, no. 12 (December 2014): 2545–51. https://doi.org/10.1002/jbmr.2283.
Magaziner JS, Orwig DL, Lyles KW, Nordsletten L, Boonen S, Adachi JD, et al. Subgroup variations in bone mineral density response to zoledronic acid after hip fracture. J Bone Miner Res. 2014 Dec;29(12):2545–51.
Magaziner, Jay S., et al. “Subgroup variations in bone mineral density response to zoledronic acid after hip fracture.J Bone Miner Res, vol. 29, no. 12, Dec. 2014, pp. 2545–51. Pubmed, doi:10.1002/jbmr.2283.
Magaziner JS, Orwig DL, Lyles KW, Nordsletten L, Boonen S, Adachi JD, Recknor C, Colón-Emeric CS, Mesenbrink P, Bucci-Rechtweg C, Su G, Johnson R, Pieper CF. Subgroup variations in bone mineral density response to zoledronic acid after hip fracture. J Bone Miner Res. 2014 Dec;29(12):2545–2551.
Journal cover image

Published In

J Bone Miner Res

DOI

EISSN

1523-4681

Publication Date

December 2014

Volume

29

Issue

12

Start / End Page

2545 / 2551

Location

England

Related Subject Headings

  • Zoledronic Acid
  • Sex Factors
  • Middle Aged
  • Male
  • Imidazoles
  • Humans
  • Hip Fractures
  • Follow-Up Studies
  • Female
  • Double-Blind Method