Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.

Journal Article (Journal Article)

Skeletal metastasis is a serious complication of many primary cancers. A common feature of tumor cells that metastasize to the bone marrow microenvironment is that they initiate a cascade of events, recruiting and presumably/potentially altering the phenotype of bone marrow mesenchymal stromal cells (MSC) to produce an environment that allows for tumor growth and in some cases, drug-resistant dormancy of latent cancer cells. Consequently the MSC population can contribute to metastatic disease through several distinct mechanisms by differentiating into cancer-associated fibroblasts (CAFs). Understanding the expression and epigenetic changes that occur as normal MSCs become associated with metastatic tumors would reveal possible therapeutic targets for treating skeletal metastasis.

Full Text

Duke Authors

Cited Authors

  • Gordon, JAR; Lisle, JW; Alman, BA; Lian, JB

Published Date

  • December 2014

Published In

Volume / Issue

  • 229 / 12

Start / End Page

  • 1884 - 1886

PubMed ID

  • 24905746

Pubmed Central ID

  • PMC4190018

Electronic International Standard Serial Number (EISSN)

  • 1097-4652

Digital Object Identifier (DOI)

  • 10.1002/jcp.24692


  • eng

Conference Location

  • United States