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Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.

Publication ,  Journal Article
Gordon, JAR; Lisle, JW; Alman, BA; Lian, JB
Published in: J Cell Physiol
December 2014

Skeletal metastasis is a serious complication of many primary cancers. A common feature of tumor cells that metastasize to the bone marrow microenvironment is that they initiate a cascade of events, recruiting and presumably/potentially altering the phenotype of bone marrow mesenchymal stromal cells (MSC) to produce an environment that allows for tumor growth and in some cases, drug-resistant dormancy of latent cancer cells. Consequently the MSC population can contribute to metastatic disease through several distinct mechanisms by differentiating into cancer-associated fibroblasts (CAFs). Understanding the expression and epigenetic changes that occur as normal MSCs become associated with metastatic tumors would reveal possible therapeutic targets for treating skeletal metastasis.

Duke Scholars

Published In

J Cell Physiol

DOI

EISSN

1097-4652

Publication Date

December 2014

Volume

229

Issue

12

Start / End Page

1884 / 1886

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Neoplasms
  • Mesenchymal Stem Cells
  • Humans
  • Fibroblasts
  • Cell Differentiation
  • Bone Neoplasms
  • Bone Marrow Cells
  • Biochemistry & Molecular Biology
 

Citation

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Gordon, J. A. R., Lisle, J. W., Alman, B. A., & Lian, J. B. (2014). Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease. J Cell Physiol, 229(12), 1884–1886. https://doi.org/10.1002/jcp.24692
Gordon, Jonathan A. R., Jennifer W. Lisle, Benjamin A. Alman, and Jane B. Lian. “Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.J Cell Physiol 229, no. 12 (December 2014): 1884–86. https://doi.org/10.1002/jcp.24692.
Gordon, Jonathan A. R., et al. “Disruption of crosstalk between mesenchymal stromal and tumor cells in bone marrow as a therapeutic target to prevent metastatic bone disease.J Cell Physiol, vol. 229, no. 12, Dec. 2014, pp. 1884–86. Pubmed, doi:10.1002/jcp.24692.
Journal cover image

Published In

J Cell Physiol

DOI

EISSN

1097-4652

Publication Date

December 2014

Volume

229

Issue

12

Start / End Page

1884 / 1886

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Signal Transduction
  • Neoplasms
  • Mesenchymal Stem Cells
  • Humans
  • Fibroblasts
  • Cell Differentiation
  • Bone Neoplasms
  • Bone Marrow Cells
  • Biochemistry & Molecular Biology