Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.

Journal Article (Journal Article;Review)

Respiratory disease is the third leading cause of death in the industrialized world. Consequently, the trachea, lungs, and cardiopulmonary vasculature have been the focus of extensive investigations. Recent studies have provided new information about the mechanisms driving lung development and differentiation. However, there is still much to learn about the ability of the adult respiratory system to undergo repair and to replace cells lost in response to injury and disease. This Review highlights the multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair.

Full Text

Duke Authors

Cited Authors

  • Hogan, BLM; Barkauskas, CE; Chapman, HA; Epstein, JA; Jain, R; Hsia, CCW; Niklason, L; Calle, E; Le, A; Randell, SH; Rock, J; Snitow, M; Krummel, M; Stripp, BR; Vu, T; White, ES; Whitsett, JA; Morrisey, EE

Published Date

  • August 7, 2014

Published In

Volume / Issue

  • 15 / 2

Start / End Page

  • 123 - 138

PubMed ID

  • 25105578

Pubmed Central ID

  • PMC4212493

Electronic International Standard Serial Number (EISSN)

  • 1875-9777

Digital Object Identifier (DOI)

  • 10.1016/j.stem.2014.07.012


  • eng

Conference Location

  • United States