Invasive gram-positive bacterial infection in cancer patients.
Journal Article (Journal Article;Review)
Systematic studies have shown that gram-positive organisms are the leading cause of invasive bacterial disease in patients with cancer. A broad range of gram-positive bacteria cause serious infections in the cancer patient with the greatest burden of disease being due to staphylococci, streptococci, and enterococci. The evolution of cancer therapy and the changing epidemiology of major gram-positive pathogens mean that ongoing efforts are needed to understand and mitigate the impact of these bacteria in patients with malignancy. The development of novel antibacterials, optimization of treatment approaches, implementation of improved vaccines, and manipulation of the microbiome are all active areas of investigation in the goal of improving the survival of the cancer patient through amelioration of the disease burden of gram-positive bacteria.
Full Text
Duke Authors
Cited Authors
- Holland, T; Fowler, VG; Shelburne, SA
Published Date
- November 15, 2014
Published In
- Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Volume / Issue
- 59 Suppl 5 /
Start / End Page
- S331 - S334
PubMed ID
- 25352626
Pubmed Central ID
- PMC4303051
Electronic International Standard Serial Number (EISSN)
- 1537-6591
Digital Object Identifier (DOI)
- 10.1093/cid/ciu598
Language
- eng
Conference Location
- United States