In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
Publication
, Journal Article
Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A
Published in: Opt Lett
October 1, 2014
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Opt Lett
DOI
EISSN
1539-4794
Publication Date
October 1, 2014
Volume
39
Issue
19
Start / End Page
5594 / 5597
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Skin
- Optics
- Mice
- Disease Models, Animal
- Burns
- Animals
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Maher, J. R., Jaedicke, V., Medina, M., Levinson, H., Selim, M. A., Brown, W. J., & Wax, A. (2014). In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett, 39(19), 5594–5597. https://doi.org/10.1364/OL.39.005594
Maher, Jason R., Volker Jaedicke, Manuel Medina, Howard Levinson, Maria Angelica Selim, William J. Brown, and Adam Wax. “In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.” Opt Lett 39, no. 19 (October 1, 2014): 5594–97. https://doi.org/10.1364/OL.39.005594.
Maher JR, Jaedicke V, Medina M, Levinson H, Selim MA, Brown WJ, et al. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett. 2014 Oct 1;39(19):5594–7.
Maher, Jason R., et al. “In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.” Opt Lett, vol. 39, no. 19, Oct. 2014, pp. 5594–97. Pubmed, doi:10.1364/OL.39.005594.
Maher JR, Jaedicke V, Medina M, Levinson H, Selim MA, Brown WJ, Wax A. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett. 2014 Oct 1;39(19):5594–5597.
Published In
Opt Lett
DOI
EISSN
1539-4794
Publication Date
October 1, 2014
Volume
39
Issue
19
Start / End Page
5594 / 5597
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Skin
- Optics
- Mice
- Disease Models, Animal
- Burns
- Animals
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering