In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.

Journal Article

Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

Full Text

Duke Authors

Cited Authors

  • Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A

Published Date

  • October 1, 2014

Published In

Volume / Issue

  • 39 / 19

Start / End Page

  • 5594 - 5597

PubMed ID

  • 25360936

Pubmed Central ID

  • 25360936

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.39.005594


  • eng

Conference Location

  • United States