In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
Publication
, Journal Article
Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A
Published in: Opt Lett
October 1, 2014
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
Duke Scholars
Published In
Opt Lett
DOI
EISSN
1539-4794
Publication Date
October 1, 2014
Volume
39
Issue
19
Start / End Page
5594 / 5597
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Skin
- Optics
- Mice
- Disease Models, Animal
- Burns
- Animals
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Maher, J. R., Jaedicke, V., Medina, M., Levinson, H., Selim, M. A., Brown, W. J., & Wax, A. (2014). In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett, 39(19), 5594–5597. https://doi.org/10.1364/OL.39.005594
Maher, Jason R., Volker Jaedicke, Manuel Medina, Howard Levinson, Maria Angelica Selim, William J. Brown, and Adam Wax. “In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.” Opt Lett 39, no. 19 (October 1, 2014): 5594–97. https://doi.org/10.1364/OL.39.005594.
Maher JR, Jaedicke V, Medina M, Levinson H, Selim MA, Brown WJ, et al. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett. 2014 Oct 1;39(19):5594–7.
Maher, Jason R., et al. “In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.” Opt Lett, vol. 39, no. 19, Oct. 2014, pp. 5594–97. Pubmed, doi:10.1364/OL.39.005594.
Maher JR, Jaedicke V, Medina M, Levinson H, Selim MA, Brown WJ, Wax A. In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography. Opt Lett. 2014 Oct 1;39(19):5594–5597.
Published In
Opt Lett
DOI
EISSN
1539-4794
Publication Date
October 1, 2014
Volume
39
Issue
19
Start / End Page
5594 / 5597
Location
United States
Related Subject Headings
- Tomography, Optical Coherence
- Skin
- Optics
- Mice
- Disease Models, Animal
- Burns
- Animals
- 5102 Atomic, molecular and optical physics
- 4009 Electronics, sensors and digital hardware
- 4006 Communications engineering