In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.

Journal Article (Journal Article)

Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.

Full Text

Duke Authors

Cited Authors

  • Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A

Published Date

  • October 1, 2014

Published In

Volume / Issue

  • 39 / 19

Start / End Page

  • 5594 - 5597

PubMed ID

  • 25360936

Pubmed Central ID

  • PMC4370176

Electronic International Standard Serial Number (EISSN)

  • 1539-4794

Digital Object Identifier (DOI)

  • 10.1364/OL.39.005594


  • eng

Conference Location

  • United States