In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
Journal Article
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
Full Text
Duke Authors
Cited Authors
- Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A
Published Date
- October 1, 2014
Published In
Volume / Issue
- 39 / 19
Start / End Page
- 5594 - 5597
PubMed ID
- 25360936
Pubmed Central ID
- 25360936
Electronic International Standard Serial Number (EISSN)
- 1539-4794
Digital Object Identifier (DOI)
- 10.1364/OL.39.005594
Language
- eng
Conference Location
- United States