In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
Journal Article (Journal Article)
Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
Full Text
Duke Authors
Cited Authors
- Maher, JR; Jaedicke, V; Medina, M; Levinson, H; Selim, MA; Brown, WJ; Wax, A
Published Date
- October 1, 2014
Published In
Volume / Issue
- 39 / 19
Start / End Page
- 5594 - 5597
PubMed ID
- 25360936
Pubmed Central ID
- PMC4370176
Electronic International Standard Serial Number (EISSN)
- 1539-4794
Digital Object Identifier (DOI)
- 10.1364/OL.39.005594
Language
- eng
Conference Location
- United States