Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.

Journal Article


This study aimed to assess vascular contrast opacification and homogeneity using single-bolus contrast administration with hybrid thoracic and abdominopelvic computed tomographic angiography in patients with severe aortic valve stenosis.

Materials and methods

Combination electrocardiogram-gated thoracic and dual-source, high-pitch abdominopelvic computed tomographic angiography examinations of 50 patients with severe aortic stenosis between December 2013 and March 2014 were reviewed. Contrast administration was individualized to patient-specific physiology. Image analysis of vascular opacification was obtained and interdependencies of vascular contrast and homogeneity of contrast distribution were assessed.


The mean volume of contrast administered was 106 ± 11.7 mL. Mean attenuation was 371 ± 90.7 Hounsfield units (HU) in the thoracic aorta and 388 ± 95.9 HU in the abdominal aorta. Homogeneous opacification was obtained throughout with coefficient of variation of 11%.


Procedural planning for transcatheter aortic valve replacement can be achieved using a single-injection bolus contrast protocol in combination with a 2-part multidetector computed tomographic image acquisition technique with optimal opacification of major arterial structures.

Full Text

Duke Authors

Cited Authors

  • Walker, WL; Boll, DT; Bueno, JM; Kiefer, TL; Vavalle, JP; Gaca, JG; Harrison, JK; Hughes, GC; Wang, A; Hurwitz, LM

Published Date

  • March 2015

Published In

Volume / Issue

  • 39 / 2

Start / End Page

  • 207 - 212

PubMed ID

  • 25564297

Pubmed Central ID

  • 25564297

Electronic International Standard Serial Number (EISSN)

  • 1532-3145

International Standard Serial Number (ISSN)

  • 0363-8715

Digital Object Identifier (DOI)

  • 10.1097/rct.0000000000000194


  • eng