Overview
Structural heart diseases, including heart valve diseases and hypertrophic cardiomyopathy
Current Appointments & Affiliations
Professor of Medicine
·
2012 - Present
Medicine, Cardiology,
Medicine
Vice Chief for Clinical Services
·
2019 - Present
Medicine, Cardiology,
Medicine
Recent Publications
Echocardiographic Changes With Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy: Exploratory Insights From the ODYSSEY-HCM Trial.
Journal Article J Am Coll Cardiol · December 16, 2025 BACKGROUND: Symptomatic nonobstructive hypertrophic cardiomyopathy (nHCM) lacks approved therapies. The ODYSSEY-HCM trial (A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy; NCT05582395), the largest to date in HCM patients, evaluating t ... Full text Link to item CiteEffect of Aficamten Compared With Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM.
Journal Article J Am Coll Cardiol · December 16, 2025 BACKGROUND: Beta-blockers have formed the mainstay of first-line therapy for symptomatic obstructive hypertrophic cardiomyopathy (HCM) for decades. Aficamten, compared with placebo, lowered left ventricular outflow tract gradients (LVOT-G), improved measur ... Full text Link to item CiteAssociations between procedural volume, costs, and outcomes of septal reduction therapies for obstructive hypertrophic cardiomyopathy in US hospitals.
Journal Article J Med Econ · December 2025 AIM: We assessed the relationship between hospital septal reduction therapy (SRT) procedural volume and clinical outcomes, healthcare resource utilization, and hospital costs. METHODS: This cross-sectional study used 2012-2022 US hospital data from the PIN ... Full text Link to item CiteRecent Grants
Percutaneous or Surgical Mitral Valve Repair in Patients with Primary Mitral Regurgitation whose mitral valve has been determined to be suitable for correction by MV repair surgery
Clinical TrialPrincipal Investigator · Awarded by Evalve, Inc · 2021 - 2033Discover- HCM
Clinical TrialPrincipal Investigator · Awarded by Bristol-Myers Squibb Company · 2022 - 2030Machine Learning Guided Precision Genetic Testing for Identification of Monogenic Cardiovascular Disorders
ResearchCo Investigator · Awarded by National Heart, Lung, and Blood Institute · 2024 - 2028View All Grants
Education, Training & Certifications
Duke University ·
1990
M.D.