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Andrew Wang

Professor of Medicine
Medicine, Cardiology
Duke Box 3428, Durham, NC 27710
Hafs Building, Room 8678A, 2301 Erwin Road, Durham, NC 27710

Selected Publications


Long-term effect of mavacamten in obstructive hypertrophic cardiomyopathy.

Journal Article Eur Heart J · December 16, 2024 BACKGROUND AND AIMS: Long-term safety and efficacy of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) are unknown. MAVA-LTE (NCT03723655) is an ongoing, 5-year, open-label extension study designed to evaluate the long-term effects ... Full text Link to item Cite

Association Between age or Duration of Diagnosis in Obstructive Hypertrophic Cardiomyopathy and Response to Mavacamten Treatment: Exploratory Analysis of the EXPLORER-HCM Trial.

Journal Article J Card Fail · December 7, 2024 BACKGROUND AND AIMS: In patients with symptomatic, obstructive hypertrophic cardiomyopathy (HCM), it is unclear if response to cardiac myosin inhibition varies with older age or a longer duration of diagnosis. This study evaluated the response of these sub ... Full text Link to item Cite

Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 128 Results from VALOR-HCM.

Journal Article Circulation · November 18, 2024 BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), VALOR-HCM trial (Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy [URL: https://clinicaltr ... Full text Link to item Cite

Standard-of-Care Medication Withdrawal in Patients With Obstructive Hypertrophic Cardiomyopathy Receiving Aficamten in FOREST-HCM.

Journal Article J Am Coll Cardiol · November 5, 2024 BACKGROUND: Standard-of-care (SoC) medications for the treatment of obstructive hypertrophic cardiomyopathy (oHCM) are recommended as first-line therapy despite the lack of evidence from controlled clinical trials and well known off-target side effects. OB ... Full text Link to item Cite

The Kansas City Cardiomyopathy Questionnaire in Relation to New York Heart Association Class.

Journal Article J Card Fail · September 28, 2024 BACKGROUND: In order to identify candidacy and treatment response for patients with obstructive hypertrophic cardiomyopathy (oHCM), clinicians need an accurate means of assessing symptoms, function, and quality of life. While the New York Heart Association ... Full text Link to item Cite

Mavacamten-Associated Temporal Changes in Left Atrial Function in Obstructive HCM: Insights From the VALOR-HCM Trial.

Journal Article JACC Cardiovasc Imaging · September 2, 2024 BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), the VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) ... Full text Link to item Cite

Serial Changes in Ventricular Strain in Symptomatic Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Insights From the VALOR-HCM Trial.

Journal Article Circ Cardiovasc Imaging · September 2024 BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) demonstra ... Full text Link to item Cite

Long-Term Safety and Efficacy of Mavacamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results of the PIONEER-OLE Study.

Journal Article J Am Heart Assoc · April 16, 2024 BACKGROUND: The phase 2 PIONEER-HCM (Phase 2 Open-label Pilot Study Evaluating Mavacamten in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction) study showed that mavacamten improved left ventricular outflo ... Full text Link to item Cite

Mavacamten for Obstructive Hypertrophic Cardiomyopathy With or Without Hypertension: Post-Hoc Analysis of the EXPLORER-HCM Trial.

Journal Article JACC Heart Fail · March 2024 BACKGROUND: Hypertension (HTN) is common in patients with hypertrophic cardiomyopathy (HCM), but its effect on the treatment of left ventricular outflow tract (LVOT) obstruction is undefined. Although elevated systolic blood pressure (SBP) may impact dynam ... Full text Link to item Cite

Effect of Mavacamten in Women Compared With Men With Obstructive Hypertrophic Cardiomyopathy: Insights From EXPLORER-HCM.

Journal Article Circulation · February 13, 2024 BACKGROUND: Compared with men, women with hypertrophic cardiomyopathy (HCM) have a higher incidence of heart failure and worse outcomes. We investigated baseline clinical and echocardiographic characteristics and response to mavacamten among women compared ... Full text Link to item Cite

Mavacamten in Patients With Hypertrophic Cardiomyopathy Referred for Septal Reduction: Week 56 Results From the VALOR-HCM Randomized Clinical Trial.

Journal Article JAMA Cardiol · October 1, 2023 IMPORTANCE: There is an unmet need for novel medical therapies before recommending invasive therapies for patients with severely symptomatic obstructive hypertrophic cardiomyopathy (HCM). Mavacamten has been shown to improve left ventricular outflow tract ... Full text Link to item Cite

Patient-Level Artificial Intelligence-Enhanced Electrocardiography in Hypertrophic Cardiomyopathy: Longitudinal Treatment and Clinical Biomarker Correlations.

Journal Article JACC Adv · October 2023 BACKGROUND: Artificial intelligence (AI) applied to 12-lead electrocardiographs (ECGs) can detect hypertrophic cardiomyopathy (HCM). OBJECTIVES: The purpose of this study was to determine if AI-enhanced ECG (AI-ECG) can track longitudinal therapeutic respo ... Full text Link to item Cite

Utilization and Outcomes of Primary Prevention Implantable Cardioverter-Defibrillators in Patients With Hypertrophic Cardiomyopathy.

Journal Article J Am Heart Assoc · August 15, 2023 Background There is uncertainty about the appropriate use of primary prevention implantable cardioverter-defibrillators (ICDs) among older patients with hypertrophic cardiomyopathy. Methods and Results Patients with hypertrophic cardiomyopathy who received ... Full text Link to item Cite

Variation in resource utilization and mortality among patients with varying MR type and severity.

Journal Article Am Heart J · June 2023 BACKGROUND: Limited data exists regarding the relationships between resource use and outcomes in patients with mitral regurgitation (MR). We examined resource utilization and outcomes across MR type and severity. METHODS: Using the Duke Echocardiography La ... Full text Link to item Cite

Long-term outcomes of phenoclusters in severe tricuspid regurgitation.

Journal Article Eur Heart J · June 1, 2023 AIMS: Severe tricuspid regurgitation (TR) exhibits high 1-year morbidity and mortality, yet long-term cardiovascular risk overall and by subgroups remains unknown. This study characterizes 5-year outcomes and identifies distinct clinical risk profiles of s ... Full text Link to item Cite

Dose-Blinded Myosin Inhibition in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Outcomes Through 32 Weeks.

Journal Article Circulation · March 14, 2023 BACKGROUND: Septal reduction therapy (SRT) in patients with intractable symptoms from obstructive hypertrophic cardiomyopathy (oHCM) is associated with variable morbidity and mortality. The VALOR-HCM trial (A Study to Evaluate Mavacamten in Adults with Sym ... Full text Link to item Cite

Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial.

Journal Article JAMA Cardiol · March 1, 2023 IMPORTANCE: Mavacamten, a cardiac myosin inhibitor, improved peak oxygen uptake (pVO2) in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in the EXPLORER-HCM study. However, the full extent of mavacamten's effects on exercise perfor ... Full text Link to item Cite

Impact of Transcatheter Mitral Valve Repair Availability on Volume and Outcomes of Surgical Repair.

Journal Article J Am Coll Cardiol · February 14, 2023 BACKGROUND: The impact of transcatheter edge-to-edge repair (TEER) on national surgical mitral valve repair (MVr) volume and outcomes is unknown. OBJECTIVES: This study aims to assess the impact of TEER availability on MVr volumes and outcomes for degenera ... Full text Link to item Cite

Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy.

Journal Article J Am Coll Cardiol · January 3, 2023 BACKGROUND: Left ventricular outflow tract (LVOT) obstruction is a major determinant of heart failure symptoms in obstructive hypertrophic cardiomyopathy (oHCM). Aficamten, a next-in-class cardiac myosin inhibitor, may lower gradients and improve symptoms ... Full text Link to item Cite

ANTIBIOTIC PROPHYLAXIS ADHERENCE AFTER VALVE REPLACEMENT SURGERY

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · 2023 Cite

Medical therapies for hypertrophic cardiomyopathy: Current state of the art.

Journal Article Prog Cardiovasc Dis · 2023 Hypertrophic cardiomyopathy (HCM) is predominantly an autosomal dominant genetic heart disease with an estimated prevalence of 1 in 200 to 1 in 500 in the general population. Clinical manifestations of HCM vary from asymptomatic state to mild functional in ... Full text Link to item Cite

Myosin Inhibition and Left Ventricular Diastolic Function in Patients With Obstructive Hypertrophic Cardiomyopathy Referred for Septal Reduction Therapy: Insights From the VALOR-HCM Study.

Journal Article Circ Cardiovasc Imaging · December 2022 BACKGROUND: In the randomized phase 3 VALOR-HCM study (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) of patients with obstructive hypertrophic cardiomyopathy ... Full text Link to item Cite

Late Durability of Mitral Repair for Ischemic Versus Nonischemic Functional Mitral Regurgitation.

Journal Article Ann Thorac Surg · October 2022 BACKGROUND: Concerns regarding long-term durability of surgical repair for functional mitral regurgitation are based on short-term data, with few comparisons of ischemic mitral regurgitation (IMR) versus nonischemic functional mitral regurgitation (NIFMR) ... Full text Link to item Cite

Imaging Considerations and Clinical Implications of Mitral Annular Disjunction.

Journal Article Circ Cardiovasc Imaging · September 2022 Mitral annular disjunction is increasingly recognized as an important anatomic feature of mitral valve disease. The presence of mitral annular disjunction, defined as separation between the left atrial wall at the point of mitral valve insertion and the le ... Full text Link to item Cite

Demographic and Regional Trends of Hypertrophic Cardiomyopathy-Related Mortality in the United States, 1999 to 2019.

Journal Article Circ Heart Fail · September 2022 BACKGROUND: Hypertrophic cardiomyopathy (HCM)-related mortality has been decreasing within the United States; however, persistent disparities in demographic subsets may exist. In this study, we assessed nationwide trends in mortality related to HCM among p ... Full text Link to item Cite

Surgical treatment of patients with infective endocarditis: changes in temporal use, patient characteristics, and mortality-a nationwide study.

Journal Article BMC Cardiovasc Disord · July 29, 2022 BACKGROUND: Valve surgery guidelines for infective endocarditis (IE) are unchanged over decades and nationwide data about the use of valve surgery do not exist. METHODS: We included patients with first-time IE (1999-2018) using Danish nationwide registries ... Full text Link to item Cite

Current recommendations and uncertainties for surgical treatment of infective endocarditis: a comparison of American and European cardiovascular guidelines.

Journal Article Eur Heart J · May 1, 2022 Surgery is an effective therapy in the treatment of left-sided infective endocarditis (IE) in patients for whom antibiotic treatment alone is unlikely to be curative or may be associated with ongoing risk of complications. However, the interplay between in ... Full text Link to item Cite

The outcome of mitral repair for degenerative versus ischemic mitral regurgitation using a single complete ring.

Journal Article J Card Surg · February 2022 BACKGROUND: The durability of surgical repair for degenerative versus ischemic mitral regurgitation (MR) is thought to be markedly different. We, therefore, examined late outcomes and durability for mitral repair in a large cohort of patients receiving a s ... Full text Link to item Cite

Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy.

Journal Article J Am Coll Cardiol · December 21, 2021 BACKGROUND: EXPLORER-HCM (Clinical Study to Evaluate Mavacamten [MYK-461] in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy) demonstrated that mavacamten, a cardiac myosin inhibitor, improves symptoms, exercise capacity, and left ventricul ... Full text Link to item Cite

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Journal Article JAMA Netw Open · January 4, 2021 IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ... Full text Link to item Cite

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial.

Journal Article Lancet · September 12, 2020 BACKGROUND: Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (LVOT) obstruction. Available pharmacological options for hypertrophic c ... Full text Link to item Cite

Identification of Undetected Monogenic Cardiovascular Disorders.

Journal Article J Am Coll Cardiol · August 18, 2020 BACKGROUND: Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. OBJECTIVES: The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses ... Full text Link to item Cite

Evaluation of Mavacamten in Symptomatic Patients With Nonobstructive Hypertrophic Cardiomyopathy.

Journal Article J Am Coll Cardiol · June 2, 2020 BACKGROUND: Patients with nonobstructive hypertrophic cardiomyopathy (nHCM) often experience a high burden of symptoms; however, there are no proven pharmacological therapies. By altering the contractile mechanics of the cardiomyocyte, myosin inhibitors ha ... Full text Link to item Cite

Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.

Journal Article Am Heart J · June 2020 BACKGROUND: Patients with bicuspid aortic valve stenosis (BAV) were excluded from all the trileaflet aortic valve stenosis (TAV) pivotal trials, and therefore, their outcomes are not clearly defined. The aim of the study was to evaluate the outcomes of tra ... Full text Link to item Cite

Study Design and Rationale of EXPLORER-HCM: Evaluation of Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy.

Journal Article Circ Heart Fail · June 2020 BACKGROUND: Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by unexplained left ventricular (LV) hypertrophy associated with dynamic LV outflow tract obstruction. Current medical therapies are nonspecific and have limited efficacy in reliev ... Full text Link to item Cite

Pre- Versus Post-Procedure Health Care Resource Utilization in Patients Undergoing Commercial Transcatheter Mitral Valve Repair.

Journal Article JACC Cardiovasc Interv · December 9, 2019 OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ... Full text Link to item Cite

The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis.

Conference Eur Heart J · July 14, 2019 AIMS: In left-sided infective endocarditis (IE), a large vegetation >10 mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the associ ... Full text Link to item Cite

Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.

Journal Article J Invasive Cardiol · July 2019 BACKGROUND: Alternative access (AA) is still required for a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to compare the clinical outcomes of patients undergoing AA vs transfemoral (TF) access. METHO ... Link to item Cite

Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.

Journal Article Ann Intern Med · June 4, 2019 BACKGROUND: Mavacamten, an orally administered, small-molecule modulator of cardiac myosin, targets underlying biomechanical abnormalities in obstructive hypertrophic cardiomyopathy (oHCM). OBJECTIVE: To characterize the effect of mavacamten on left ventri ... Full text Link to item Cite

Association between the timing of surgery for complicated, left-sided infective endocarditis and survival.

Journal Article Am Heart J · April 2019 BACKGROUND: In patients with active infective endocarditis (IE), the relationship between timing of surgery and survival is uncertain. The objective was to evaluate clinical characteristics associated with timing of surgery and the association between surg ... Full text Link to item Cite

Duration and complications of diabetes mellitus and the associated risk of infective endocarditis.

Journal Article Int J Cardiol · March 1, 2019 BACKGROUND: Long duration of diabetes mellitus (DM) is associated with an increased risk of infection, however no studies have yet focused on the duration of DM and the associated risk of infective endocarditis (IE). METHODS: Patients with DM were identifi ... Full text Link to item Cite

One-Year Outcomes After MitraClip for Functional Mitral Regurgitation.

Journal Article Circulation · January 2, 2019 BACKGROUND: Secondary mitral regurgitation (SMR) occurs in the absence of organic mitral valve disease and may develop as the left ventricle dilates or remodels or as a result of leaflet tethering with impaired coaptation, most commonly from apical and lat ... Full text Link to item Cite

Long-term outcomes of mitral regurgitation by type and severity.

Journal Article Am Heart J · September 2018 BACKGROUND: We aimed to determine the association of MR severity and type with all-cause death in a large, real-world, clinical setting. METHODS: We reviewed full echocardiography studies at Duke Echocardiography Laboratory (01/01/1995-12/31/2010), classif ... Full text Link to item Cite

Management Considerations in Infective Endocarditis: A Review.

Journal Article JAMA · July 3, 2018 IMPORTANCE: Infective endocarditis occurs in approximately 15 of 100 000 people in the United States and has increased in incidence. Clinicians must make treatment decisions with respect to prophylaxis, surgical management, specific antibiotics, and the le ... Full text Link to item Cite

Using a Regent Aortic Valve in a Small Annulus Mitral Position Is a Viable Option.

Journal Article Ann Thorac Surg · April 2018 BACKGROUND: Outcome of mitral valve replacement in extreme scenarios of small mitral annulus with the use of the Regent mechanical aortic valve is not well documented. METHODS: Records were examined in 31 consecutive patients who underwent mitral valve rep ... Full text Open Access Link to item Cite

Left bundle branch block before transcatheter aortic valve replacement: Is there a risk?

Journal Article Circulation: Cardiovascular Interventions · January 1, 2018 Full text Cite

The Modified Ross Procedure with Prosthetic Graft Wrap Does Not Prevent Autograft Failure.

Journal Article J Heart Valve Dis · November 2017 The modified Ross procedure, which involves replacement of the aortic valve with a pulmonary autograft root supported within a Dacron tube graft, was developed with the goal of preventing late autograft dilatation and associated aortic insufficiency. The c ... Link to item Cite

Influence of vancomycin minimum inhibitory concentration on the outcome of methicillin-susceptible Staphylococcus aureus left-sided infective endocarditis treated with antistaphylococcal β-lactam antibiotics: a prospective cohort study by the International Collaboration on Endocarditis.

Journal Article Clin Microbiol Infect · August 2017 OBJECTIVES: Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is ≥1.5 mg/L. We aimed to validate this using the Internatio ... Full text Open Access Link to item Cite

Cardiovascular events and hospital resource utilization pre- and post-transcatheter mitral valve repair in high-surgical risk patients.

Journal Article Am Heart J · July 2017 UNLABELLED: MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST I ... Full text Link to item Cite

PREDICTORS OF MORTALITY AFTER TAVR IN A “REAL WORLD” SETTING

Conference Journal of the American College of Cardiology · March 2017 Full text Cite

Hypertrophic Cardiomyopathy: New Evidence Since the 2011 American Cardiology of Cardiology Foundation and American Heart Association Guideline.

Journal Article Curr Cardiol Rep · July 2016 Since publication of the 2011 American College of Cardiology Foundation (ACCF) and American Heart Association (AHA) Guideline for the diagnosis and treatment of hypertrophic cardiomyopathy (HCM), more recent studies offer greater insights about this condit ... Full text Link to item Cite

Valve-in-Valve Transcatheter Valve Implantation in the Nonaortic Position.

Journal Article J Card Surg · May 2016 BACKGROUND: Transcatheter valve-in-valve (VIV) procedures are an alternative to standard surgical valve replacement in high risk patients. METHODS: Cases in which a commercially approved transcatheter aortic valve replacement (TAVR) device was used for a n ... Full text Link to item Cite

Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis.

Journal Article J Am Heart Assoc · April 18, 2016 BACKGROUND: Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop and validate a model of clinical characteristics to predict 6-month mortality in IE. METHODS AND RESULTS: Using a lar ... Full text Link to item Cite

An Approach to Improve the Negative Predictive Value and Clinical Utility of Transthoracic Echocardiography in Suspected Native Valve Infective Endocarditis.

Journal Article J Am Soc Echocardiogr · April 2016 BACKGROUND: In patients with suspected native valve infective endocarditis, current guidelines recommend initial transthoracic echocardiography (TTE) followed by transesophageal echocardiography (TEE) if clinical suspicion remains. The guidelines do not ac ... Full text Link to item Cite

Infective Endocarditis.

Journal Article J Intensive Care Med · March 2016 Infective endocarditis (IE) is a noncontagious infection of the endocardium and heart valves. The epidemiology of IE has shifted recently with an increase in health care-associated IE. Infective endocarditis requiring intensive care unit stay is increasing ... Full text Link to item Cite

Practice gaps in the care of mitral valve regurgitation: Insights from the American College of Cardiology mitral regurgitation gap analysis and advisory panel.

Journal Article Am Heart J · February 2016 BACKGROUND: The revised 2014 American College of Cardiology (ACC)/American Heart Association valvular heart disease guidelines provide evidenced-based recommendations for the management of mitral regurgitation (MR). However, knowledge gaps related to our e ... Full text Link to item Cite

Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II.

Journal Article J Am Coll Cardiol · December 29, 2015 BACKGROUND: In EVEREST II (Endovascular Valve Edge-to-Edge Repair Study), treatment of mitral regurgitation (MR) with a novel percutaneous device showed superior safety compared with surgery, but less effective reduction in MR at 1 year. OBJECTIVES: This s ... Full text Link to item Cite

Resection of Carcinoid Tumor Metastatic to the Right Ventricle and Tricuspid Valve.

Journal Article Ann Thorac Surg · December 2015 Carcinoid tumors rarely metastasize to the heart, and previous reports involved the myocardium only. We present a case of carcinoid tumor metastatic to the right ventricle (RV) and tricuspid valve. Preoperative cardiac magnetic resonance imaging (CMR) show ... Full text Link to item Cite

Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction.

Journal Article Eur Heart J · October 21, 2015 AIMS: The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes o ... Full text Link to item Cite

RESPONSE: Look Inward First

Journal Article Journal of the American College of Cardiology · August 25, 2015 Cite

Factor VIIa for Annulus Rupture After Transcatheter Aortic Valve Replacement.

Journal Article Ann Thorac Surg · July 2015 Over the last decade, transcatheter aortic valve replacement (TAVR) has emerged as an effective treatment for inoperable and selected high surgical-risk patients with aortic stenosis. However, management of procedural complications with TAVR represents a m ... Full text Link to item Cite

Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement.

Journal Article Am J Cardiol · June 1, 2015 This study sought to compare the accuracy of 2-dimensional transesophageal echocardiography (TEE) and computed tomography angiography (CTA) for noninvasive aortic annular sizing as required for transcatheter aortic valve implantation (TAVI). Direct intraop ... Full text Link to item Cite

COCATS 4 Task Force 5: Training in Echocardiography.

Journal Article J Am Coll Cardiol · May 5, 2015 Full text Link to item Cite

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Journal Article Antimicrob Agents Chemother · April 2015 Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ... Full text Link to item Cite

Bridge to long-term mechanical circulatory support with a left ventricular assist device: novel use of transcatheter aortic valve replacement.

Journal Article Ann Thorac Surg · April 2015 We describe the use of transcatheter aortic valve replacement to allow for bridging to a left ventricular assist device in a patient with end-stage heart failure, secondary to nonischemic cardiomyopathy and severe bioprosthetic aortic valve regurgitation. ... Full text Link to item Cite

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

Journal Article Clin Infect Dis · March 1, 2015 BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ... Full text Link to item Cite

Impact of diabetes in patients with pulmonary hypertension.

Journal Article Pulm Circ · March 2015 Diabetes complicates management in a number of disease states and adversely impacts survival; how diabetes affects patients with pulmonary hypertension (PH) has not been well characterized. With insulin resistance having recently been demonstrated in PH, w ... Full text Open Access Link to item Cite

One-year outcome following biological or mechanical valve replacement for infective endocarditis.

Journal Article Int J Cardiol · January 15, 2015 BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ... Full text Link to item Cite

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.

Journal Article Circulation · January 13, 2015 BACKGROUND: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) ... Full text Link to item Cite

Assessment of single-bolus contrast administration technique using hybrid dual-source ECG-gated thoracic and dual-source non-ECG-gated high-pitch abdominopelvic CT acquisitions for procedural planning before transcatheter aortic valve replacement.

Journal Article J Comput Assist Tomogr · 2015 PURPOSE: This study aimed to assess vascular contrast opacification and homogeneity using single-bolus contrast administration with hybrid thoracic and abdominopelvic computed tomographic angiography in patients with severe aortic valve stenosis. MATERIALS ... Full text Link to item Cite

Evaluation of renal function before and after percutaneous mitral valve repair.

Journal Article Circ Cardiovasc Interv · January 2015 BACKGROUND: Chronic kidney disease (CKD) is strongly related to outcome in cardiovascular diseases. The relationship between treatment of mitral regurgitation (MR) and renal function is not well described. We sought to evaluate renal function before and af ... Full text Link to item Cite

Infective endocarditis

Chapter · November 1, 2014 Infective endocarditis is defined as infection of a heart valve or other cardiac tissue. This diagnosis has broadened beyond infections involving native cardiac tissue or prosthetic heart valves to include infections of implanted intracardiac devices. Desp ... Full text Cite

Improved functional status and quality of life in prohibitive surgical risk patients with degenerative mitral regurgitation after transcatheter mitral valve repair.

Journal Article J Am Coll Cardiol · July 15, 2014 BACKGROUND: Surgical mitral valve repair (SMVR) remains the gold standard for severe degenerative mitral regurgitation (DMR). However, the results with transcatheter mitral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously repor ... Full text Link to item Cite

Analysis of geographic variations in the diagnosis and treatment of patients with aortic stenosis in North Carolina.

Journal Article Am J Cardiol · June 1, 2014 Despite advances in the treatment of aortic stenosis (AS), many patients with AS remain untreated. Barriers to accessing cardiovascular surgical care may play a role in this undertreatment. We sought to examine whether there are geographic variations in th ... Full text Link to item Cite

In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis.

Journal Article JAMA Intern Med · September 9, 2013 IMPORTANCE: There are limited prospective, controlled data evaluating survival in patients receiving early surgery vs medical therapy for prosthetic valve endocarditis (PVE). OBJECTIVE: To determine the in-hospital and 1-year mortality in patients with PVE ... Full text Link to item Cite

4-year results of a randomized controlled trial of percutaneous repair versus surgery for mitral regurgitation.

Journal Article J Am Coll Cardiol · July 23, 2013 OBJECTIVES: This study sought to evaluate 4-year outcomes of percutaneous repair versus surgery for mitral regurgitation. BACKGROUND: Transcatheter therapies are being developed to treat valvular heart disease. In the EVEREST (Endovascular Valve Edge-to-Ed ... Full text Link to item Cite

Invasive hemodynamic evaluation in patients with mechanical aortic valves.

Journal Article Catheter Cardiovasc Interv · July 1, 2013 Invasive hemodynamic evaluation in the patient with a mechanical aortic valve has in the past required transseptal or apical left ventricular puncture in order to obtain left ventricular pressure measurements. Over the last few years, several case reports ... Full text Link to item Cite

Reply to Tleyjeh and Baddour.

Journal Article Clin Infect Dis · June 2013 Full text Link to item Cite

Correlations between physician-perceived functional status, patient-perceived health status, and cardiopulmonary exercise results in hypertrophic cardiomyopathy.

Journal Article Qual Life Res · April 2013 BACKGROUND: Dyspnea and the resulting functional impairment are a common complication in hypertrophic cardiomyopathy (HCM). The relationship between physician-perceived functional status, patient-perceived health status, and objective exercise test results ... Full text Link to item Cite

Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.

Journal Article Clin Infect Dis · January 2013 BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ... Full text Link to item Cite

HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.

Journal Article PLoS One · 2013 The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ... Full text Link to item Cite

Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices.

Journal Article JAMA · April 25, 2012 Featured Publication CONTEXT: Infection of implantable cardiac devices is an emerging disease with significant morbidity, mortality, and health care costs. OBJECTIVES: To describe the clinical characteristics and outcome of cardiac device infective endocarditis (CDIE) with att ... Full text Link to item Cite

Effects of atrial fibrillation on treatment of mitral regurgitation in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) randomized trial.

Journal Article J Am Coll Cardiol · April 3, 2012 Featured Publication OBJECTIVES: The purpose of this study was to characterize patients with mitral regurgitation (MR) and atrial fibrillation (AF) treated percutaneously using the MitraClip device (Abbott Vascular, Abbott Park, Illinois) and compare the results with surgery i ... Full text Link to item Cite

EVEREST II randomized clinical trial: predictors of mitral valve replacement in de novo surgery or after the MitraClip procedure.

Journal Article J Thorac Cardiovasc Surg · April 2012 OBJECTIVE: The Endovascular Valve Edge-to-Edge Repair Study (EVEREST II) is a prospective, multicenter, randomized controlled trial comparing percutaneous repair with the MitraClip device to mitral valve (MV) surgery in the treatment of mitral regurgitatio ... Full text Link to item Cite

Management of patients with bicuspid aortic valve disease.

Journal Article Curr Treat Options Cardiovasc Med · December 2011 Our approach to the management of the patient with a bicuspid aortic valve (BAV) takes several factors into consideration. First, is the dysfunction of the valve due to aortic stenosis (AS), aortic regurgitation (AR), or a combination of stenosis and regur ... Full text Link to item Cite

Recent progress in the understanding of infective endocarditis.

Journal Article Curr Treat Options Cardiovasc Med · December 2011 Infective endocarditis is an uncommon cardiac condition but is associated with significant morbidity and mortality despite advancements in diagnosis and treatment. Recent epidemiologic changes in this disease have resulted in additional challenges for trea ... Full text Link to item Cite

Association between valvular surgery and mortality among patients with infective endocarditis complicated by heart failure.

Journal Article JAMA · November 23, 2011 Featured Publication CONTEXT: Heart failure (HF) is the most common complication of infective endocarditis. However, clinical characteristics of HF in patients with infective endocarditis, use of surgical therapy, and their associations with patient outcome are not well descri ... Full text Link to item Cite

Alcohol septal ablation for the treatment of hypertrophic obstructive cardiomyopathy. A multicenter North American registry.

Journal Article J Am Coll Cardiol · November 22, 2011 Featured Publication OBJECTIVES: The purpose of the study is to identify the predictors of clinical outcome (mortality and survival without repeat septal reduction procedures) of alcohol septal ablation for the treatment of patients with hypertrophic obstructive cardiomyopathy ... Full text Link to item Cite

Association of anemia and long-term survival in patients with pulmonary hypertension.

Journal Article Int J Cardiol · August 4, 2011 BACKGROUND: Anemia is a marker of worsened clinical outcome in patients with heart failure from left ventricular dysfunction. Pulmonary hypertension often results in right ventricular dysfunction. Accordingly we sought to examine the association of hemoglo ... Full text Open Access Link to item Cite

Association of troponin T, detected with highly sensitive assay, and outcomes in infective endocarditis.

Journal Article Am J Cardiol · August 1, 2011 Troponin levels have been correlated with adverse outcomes in multiple disease processes, including congestive heart failure, acute coronary syndromes, sepsis, and, in a few small series, infective endocarditis. We hypothesized that a novel measurement of ... Full text Link to item Cite

Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease.

Journal Article J Heart Valve Dis · July 2011 BACKGROUND AND AIM OF THE STUDY: Bicuspid aortic valve (BAV) disease is associated with an aortopathy resulting in aneurysmal dilatation spanning the root, ascending, and arch segments. To date, no large series of proximal aortic replacement in this popula ... Link to item Cite

Response to inhaled nitric oxide predicts survival in patients with pulmonary hypertension.

Journal Article J Card Fail · April 2011 OBJECTIVE: To examine the ability of vasodilator response to predict survival in a diverse cohort of patients with pulmonary hypertension (PH). PATIENTS & METHODS: A total of 214 consecutive treatment-naive patients referred for invasive PH evaluation were ... Full text Open Access Link to item Cite

Anatomic and clinical correlates of septal morphology in hypertrophic cardiomyopathy.

Journal Article Eur J Echocardiogr · February 2011 UNLABELLED: Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical ... Full text Link to item Cite

Anomalous right coronary artery origin from the pulmonary artery (ARCAPA) coexisting with obstructive atherosclerotic disease of the left coronary artery.

Journal Article J Invasive Cardiol · January 2011 Coronary artery anomalies arising from the pulmonary artery are rare, result in reversed flow in the affected coronary artery, and are commonly associated with myocardial ischemia in infancy or childhood. Uncorrected survival to adult age is rare. We prese ... Link to item Cite

Pulmonary hypertension and elevated transpulmonary gradient in patients with mitral stenosis.

Journal Article J Heart Valve Dis · November 2010 BACKGROUND AND AIM OF THE STUDY: Pulmonary hypertension frequently complicates mitral stenosis, with a subset of these patients exhibiting pressures well in excess of their mitral valve hemodynamics. The prevalence of this condition and its impact on clini ... Open Access Link to item Cite

Relation of level of B-type natriuretic peptide with outcomes in patients with infective endocarditis.

Journal Article Am J Cardiol · October 1, 2010 Elevated B-type natriuretic peptide (BNP) is a marker of poor outcomes in heart failure, acute coronary syndromes, and sepsis. Elevated cardiac troponin I (cTnI) is associated with adverse outcomes in infective endocarditis. It was hypothesized that elevat ... Full text Link to item Cite

Revisiting the effect of referral bias on the clinical spectrum of infective endocarditis in adults.

Journal Article Eur J Clin Microbiol Infect Dis · October 2010 Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infectiv ... Full text Link to item Cite

Percutaneous heart valve replacement for aortic stenosis: state of the evidence.

Journal Article Ann Intern Med · September 7, 2010 Featured Publication Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. Perioperative mortality, however, is high among many patients for whom SAVR may be indicated. Percut ... Full text Link to item Cite

Infective Endocarditis

Journal Article · May 21, 2010 Full text Cite

Meta-analyses of septal reduction therapies for obstructive hypertrophic cardiomyopathy: comparative rates of overall mortality and sudden cardiac death after treatment.

Journal Article Circ Cardiovasc Interv · April 2010 Featured Publication BACKGROUND: Septal reduction for obstructive hypertrophic cardiomyopathy may be performed by surgical myectomy or alcohol septal ablation (ASA). Unlike surgical myectomy, ASA creates an intramyocardial scar that may potentiate the risk of ventricular arrhy ... Full text Link to item Cite

Analysis of the impact of early surgery on in-hospital mortality of native valve endocarditis: use of propensity score and instrumental variable methods to adjust for treatment-selection bias.

Journal Article Circulation · March 2, 2010 Featured Publication BACKGROUND: The impact of early surgery on mortality in patients with native valve endocarditis (NVE) is unresolved. This study sought to evaluate valve surgery compared with medical therapy for NVE and to identify characteristics of patients who are most ... Full text Open Access Link to item Cite

Impact of anemia in patients with pulmonary hypertension

Journal Article EUROPEAN HEART JOURNAL · September 1, 2009 Open Access Link to item Cite

Racial disparities in survival in patients with pulmonary hypertension

Journal Article EUROPEAN HEART JOURNAL · September 1, 2009 Link to item Cite

Pure annular dilation as a cause of mitral regurgitation: a clinically distinct entity of female heart disease.

Journal Article J Heart Valve Dis · May 2009 BACKGROUND AND AIM OF THE STUDY: Pure annular dilation (PAD) is a recognized etiology of mitral regurgitation, yet few data exist to define the prognostic profile of this disorder relative to other etiologies, such as ischemia or myxomatous prolapse. METHO ... Link to item Cite

Clinical presentation, etiology, and outcome of infective endocarditis in the 21st century: the International Collaboration on Endocarditis-Prospective Cohort Study.

Journal Article Arch Intern Med · March 9, 2009 Featured Publication BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE ... Full text Link to item Cite

Impact of left ventricular dysfunction on hospital mortality among patients undergoing elective percutaneous coronary intervention.

Journal Article Am J Cardiol · February 1, 2009 Many patients with systolic dysfunction undergo elective percutaneous coronary intervention (PCI) despite the unknown risk and limited data supporting its use. Therefore, the aim of this study was to evaluate the association between the severity of left ve ... Full text Link to item Cite

Infective Endocarditis

Chapter · January 20, 2009 "--JAMA Part of the Pediatric Practice series, Pediatric Practice: Infectious Diseases is filled with practical, clinically relevant guidance for successful infectious disease management. ... Cite

Medical therapy for rheumatic heart disease: is it time to be proactive rather than reactive?

Journal Article Indian Heart J · 2009 Rheumatic Heart Disease (RHD) is well known to be an active inflammatory process which develops progressive calcification and leaflet thickening over time. The potential for statin therapy in slowing the progression of valvular heart disease is still contr ... Link to item Cite

Effect of percutaneous mitral repair with the MitraClip device on mitral valve area and gradient.

Journal Article EuroIntervention · January 2009 AIMS: Percutaneous repair of mitral regurgitation (MR) by leaflet apposition using a clip deployed via transseptal catheterisation is undergoing evaluation. METHODS AND RESULTS: In order to detect the potential for clinically significant left ventricular i ... Full text Link to item Cite

Clinical problem-solving. Taken out of context.

Journal Article N Engl J Med · December 4, 2008 Featured Publication Full text Link to item Cite

Taken out of context

Journal Article New England Journal of Medicine · December 4, 2008 A 25-year-old woman with a history of depression, mitral-valve prolapse, and migraine headaches presented to a hospital emergency department with a 3-day history of subjective fever, diffuse arthralgia, and a severe generalized headache that was not charac ... Cite

Response to Kuvin

Journal Article Circulation · July 29, 2008 Cite

Echocardiographic risk stratification for early surgery with endocarditis: a cost-effectiveness analysis.

Journal Article Heart · May 2008 BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ... Full text Link to item Cite

Non-HACEK gram-negative bacillus endocarditis.

Journal Article Ann Intern Med · December 18, 2007 BACKGROUND: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, ... Full text Link to item Cite

Contemporary clinical profile and outcome of prosthetic valve endocarditis.

Journal Article JAMA · March 28, 2007 Featured Publication CONTEXT: Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined. OBJECTIVES: To describe the prevalence, clinical characteristics, and outcome of ... Full text Link to item Cite

Early surgery in patients with infective endocarditis: a propensity score analysis.

Journal Article Clin Infect Dis · February 1, 2007 Featured Publication BACKGROUND: An accurate assessment of the predictors of long-term mortality in patients with infective endocarditis is not possible using retrospective data because of inherent treatment biases and predictable imbalances in the distribution of prognostic f ... Full text Link to item Cite

Low-molecular-weight heparin for thromboprophylaxis in pregnant women with mechanical heart valves.

Journal Article J Matern Fetal Neonatal Med · September 2006 BACKGROUND: Pregnancy in a woman with a mechanical heart valve is a life-threatening situation. Due to the inability of unfractionated heparin to prevent valvular thromboses, warfarin or other vitamin K antagonists have been the preferred anticoagulants fo ... Full text Link to item Cite

Peripheral blood levels of matrix metalloproteinases in patients referred for percutaneous balloon mitral valve commissurotomy.

Journal Article J Heart Valve Dis · May 2006 BACKGROUND AND AIM OF THE STUDY: Inflammation may play a central role in the progression of stenotic valvular heart disease. Serum levels of matrix metalloproteinases (MMPs), markers of extracellular matrix (ECM) turnover and potential markers of active in ... Link to item Cite

Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database.

Other Scand J Infect Dis · 2006 The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on End ... Full text Link to item Cite

Clinical problem-solving. A hole in the argument.

Journal Article N Engl J Med · December 1, 2005 Full text Link to item Cite

Use of surgery in patients with native valve infective endocarditis: results from the International Collaboration on Endocarditis Merged Database.

Journal Article Am Heart J · November 2005 Featured Publication BACKGROUND: Early surgery has been shown to be beneficial for patients with infective endocarditis (IE), yet surgery is not used in most patients. Evidence of the uncertainty around the use of surgery can be found in the wide variations in the use of cardi ... Full text Link to item Cite

The use and effect of surgical therapy for prosthetic valve infective endocarditis: a propensity analysis of a multicenter, international cohort.

Journal Article Am Heart J · November 2005 Featured Publication BACKGROUND: Although surgical intervention is often used in the treatment of prosthetic valve infective endocarditis (PVIE), an understanding of its effect on survival has been limited by the biases of observational studies and lack of controlled trials. M ... Full text Link to item Cite

Clinical characteristics and outcome of aortic endocarditis with periannular abscess in the International Collaboration on Endocarditis Merged Database.

Journal Article Am J Cardiol · October 1, 2005 The aims of this study were to determine the clinical characteristics and outcome of patients who had definite infective endocarditis (IE) complicated by aortic ring abscess formation that was detected with transesophageal echocardiography (TEE) and to det ... Full text Link to item Cite

The response to inhaled nitric oxide in patients with pulmonary artery hypertension is not masked by baseline vasodilator use.

Journal Article Am Heart J · October 2005 BACKGROUND: Assessment of pulmonary vasodilator responsiveness is important in determining the prognosis and management of patients with pulmonary hypertension. Many patients, however, are already on vasodilators at the time of testing. It is unclear if th ... Full text Link to item Cite

Risk of endocarditis among patients with prosthetic valves and Staphylococcus aureus bacteremia.

Journal Article Am J Med · March 2005 PURPOSE: Staphylococcus aureus is a common cause of bacteremia and of native valve infective endocarditis. However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to defin ... Full text Link to item Cite

Undercover and overlooked.

Journal Article N Engl J Med · December 30, 2004 Full text Link to item Cite

Undercover and overlooked [4] (multiple letters)

Journal Article New England Journal of Medicine · December 30, 2004 Cite

Undercover and overlooked - Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · December 30, 2004 Link to item Cite

Current Treatment Options for Patients with Endocarditis: The Evolving Indications for Cardiac Surgery.

Journal Article Curr Treat Options Cardiovasc Med · December 2004 Infective endocarditis (IE) is a serious and deadly disease. Despite medical advances over the past half century, more than one half of patients with IE suffer a serious complication, and the mortality rate remains approximately 20% during the initial hosp ... Full text Link to item Cite

Clinical problem-solving. Undercover and overlooked.

Journal Article N Engl J Med · September 2, 2004 Full text Link to item Cite

Early predictors of in-hospital death in infective endocarditis.

Journal Article Circulation · April 13, 2004 Featured Publication BACKGROUND: Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE. METHODS AND RESULTS: Two hundred si ... Full text Link to item Cite

Usefulness of percutaneous balloon mitral commissurotomy in preventing the development of atrial fibrillation in patients with mitral stenosis.

Journal Article Am J Cardiol · April 1, 2004 A prospective cohort of patients with mitral stenosis and no history of atrial arrhythmias showed no decrease in the incidence of atrial fibrillation (AF) after successful versus unsuccessful Inoue balloon percutaneous balloon mitral valve commissurotomy. ... Full text Link to item Cite

Left main coronary artery-to-pulmonary artery fistula with severe aneurysmal dilatation.

Journal Article Ann Thorac Surg · March 2004 Coronary artery fistulas (CAF) are rare abnormalities that can be symptomatic or asymptomatic. Most drain into the right ventricle or pulmonary artery, though a variety of other drainage sites have been reported. We report the results of the surgical closu ... Full text Link to item Cite

Five-year clinical and echocardiographic evaluation of the Das AngelWings atrial septal occluder.

Journal Article Am Heart J · February 2004 BACKGROUND: The late outcome of patients treated with atrial septal occluder devices remains incompletely defined. The purpose of this study was to assess the late outcome (range 4-7 years postprocedure) of patients in whom the Das AngelWings septal occlud ... Full text Link to item Cite

C-reactive protein elevation independently influences the procedural success of percutaneous balloon mitral valve commissurotomy.

Journal Article Am Heart J · December 2003 BACKGROUND: Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon ... Full text Link to item Cite

Fenoldopam mesylate for the prevention of contrast-induced nephropathy: a randomized controlled trial.

Journal Article JAMA · November 5, 2003 Featured Publication CONTEXT: The development of contrast-induced nephropathy in patients undergoing invasive cardiac procedures is associated with a marked increase in cardiovascular morbidity and mortality. Fenoldopam mesylate, a specific agonist of the dopamine-1 receptor, ... Full text Link to item Cite

Valvular heart disease.

Journal Article J Am Coll Cardiol · July 16, 2003 Full text Link to item Cite

Trained and supervised physician assistants can safely perform diagnostic cardiac catheterization with coronary angiography.

Journal Article Catheter Cardiovasc Interv · June 2003 Using a prospectively collected database of patients undergoing cardiac catheterization, we sought to compare the outcomes of procedures performed by supervised physician assistants (PAs) with those performed by supervised cardiology fellows-in-training. O ... Full text Link to item Cite

Early predictors of mortality in patients with endocarditis

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 19, 2003 Link to item Cite

Exercise echocardiographic comparison of pulmonary autograft and aortic homograft replacements for aortic valve disease in adults.

Journal Article J Heart Valve Dis · March 2003 Featured Publication BACKGROUND AND AIM OF THE STUDY: The pulmonary autograft, or Ross procedure, has theoretical hemodynamic benefits over other aortic valve replacements. The hemodynamic performance of the pulmonary autograft and pulmonary homograft components of this proced ... Link to item Cite

Radiocontrast nephropathy: a time for affirmative action.

Journal Article J Invasive Cardiol · January 2003 Link to item Cite

Contrast nephropathy : an evidence-based approach to prevention.

Journal Article Am J Cardiovasc Drugs · 2003 Contrast-induced nephropathy occurs in 2-10% of patients exposed to intravascular radiographic contrast agents and results in significant morbidity and mortality. Although the exact mechanism of this disorder has not been fully elucidated, contrast nephrop ... Full text Link to item Cite

Fenoldopam mesylate blocks reductions in renal plasma flow after radiocontrast dye infusion: a pilot trial in the prevention of contrast nephropathy.

Journal Article Am Heart J · May 2002 Featured Publication BACKGROUND: Radiocontrast nephropathy (RCN) is a common source of acute renal failure in hospitalized patients and is associated with increased morbidity and mortality rates. Fenoldopam mesylate is a dopamine A1 receptor agonist that augments renal plasma ... Full text Link to item Cite

Serial echocardiographic evaluation of restenosis after successful percutaneous mitral commissurotomy.

Journal Article J Am Coll Cardiol · January 16, 2002 OBJECTIVES: This study was designed to determine predictors of restenosis after successful percutaneous mitral commissurotomy (PMC) and its relationship to late clinical outcome. BACKGROUND: The restenosis rate after PMC and its relationship to late clinic ... Full text Link to item Cite

Reply [2]

Journal Article Journal of the American Society of Echocardiography · January 1, 2002 Full text Cite

Is port-access applicable to complex mitral valve repair?

Conference HEART SURGERY FORUM · January 1, 2002 Link to item Cite

Comparison of results of percutaneous balloon mitral commissurotomy in patients aged > or = 65 years with those in patients aged < 65 years.

Journal Article Am J Cardiol · November 1, 2001 Percutaneous balloon mitral commissurotomy (PBMC) is now first-line therapy in patients with symptomatic mitral stenosis (MS) and favorable valve morphology. Unfortunately, the outcome of Medicare-aged patients undergoing this procedure has not previously ... Full text Link to item Cite

Cardiac conduction abnormalities in endocarditis defined by the Duke criteria.

Journal Article Am Heart J · August 2001 BACKGROUND: Cardiac conduction abnormalities occur in endocarditis and have been associated with infection extension and increased mortality. There have been no prospective studies of electrocardiographic (ECG) conduction changes in endocarditis. We examin ... Full text Link to item Cite

Correlation between quantitative left atrial spontaneous echocardiographic contrast and intact fibrinogen levels in mitral stenosis.

Journal Article J Am Soc Echocardiogr · April 2001 An association between left atrial spontaneous echocardiographic contrast (LASEC) and thromboembolic events has been recognized. However, the appearance of LASEC and the assessment of its intensity are gain dependent. To evaluate the relation between LASEC ... Full text Link to item Cite

Cardiac conduction abnormalites complicating infective endocarditis

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2001 Link to item Cite

Inhaled nitric oxide selectively dilates pulmonary vasculature in adult patients with pulmonary hypertension, irrespective of etiology.

Journal Article J Am Coll Cardiol · December 2000 OBJECTIVES: We sought to compare the responses of patients with pulmonary hypertension from primary and secondary causes (PPH and SPH, respectively) to inhaled nitric oxide (iNO) in the cardiac catheterization laboratory. BACKGROUND: Pulmonary hypertension ... Full text Link to item Cite

Congenital agenesis of the right pulmonary artery.

Journal Article Catheter Cardiovasc Interv · December 2000 A 44-year-old woman with recurrent pulmonary infections developed severe hemoptysis. Chest radiography revealed a hypoplastic right lung. Absence of the right pulmonary artery, a very rare congenital anomaly, was demonstrated by computed tomography and car ... Full text Link to item Cite

Reply from the authors.

Journal Article Kidney Int · November 2000 Full text Link to item Cite

Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism.

Journal Article Kidney Int · April 2000 BACKGROUND: Endothelin is a potent vasoconstrictor that has been implicated in the pathogenesis of radiocontrast nephrotoxicity. Endothelin antagonists may reduce the renal hemodynamic abnormalities following radiocontrast administration. METHODS: One hund ... Full text Link to item Cite

Assessing the severity of mitral stenosis: variability between noninvasive and invasive measurements in patients with symptomatic mitral valve stenosis.

Journal Article Am Heart J · October 1999 BACKGROUND: This study evaluated the correlation and variability between noninvasive and invasive measures of mitral stenosis severity before and after balloon mitral commissurotomy (BMC) in a large group of patients with symptomatic mitral stenosis. Facto ... Full text Link to item Cite

Hypoxemia after prior cardiac surgery due to interatrial shunting and its treatment with a novel transcatheter occlusion device.

Journal Article Catheter Cardiovasc Interv · April 1999 We describe two unusual cases of hypoxemia after cardiac surgery due to intracardiac right-to-left shunting through a patent foramen ovale or atrial septal defect. The interatrial defects were successfully occluded by placement of a novel, transcather devi ... Full text Link to item Cite

Predictors and significance of atrial rhythm before and six months after percutaneous balloon mitral commissurotomy.

Journal Article Am J Cardiol · January 1, 1999 Clinical, echocardiographic, and cardiac catheterization data were evaluated in 263 patients with mitral stenosis who were undergoing balloon commissurotomy to determine the predictors of atrial rhythm and its effect on functional status. Conversion from a ... Full text Link to item Cite

What does the left atrial v wave signify during balloon commissurotomy of mitral stenosis?

Journal Article Am J Cardiol · December 1, 1998 Left atrial v-wave amplitude has been associated with the presence and severity of chronic mitral regurgitation (MR) but it has not been evaluated for the detection of acute MR. We evaluated the left atrial v-wave amplitude of 205 consecutive patients with ... Full text Link to item Cite

Massive pulmonary edema and death after prostacyclin infusion in a patient with pulmonary veno-occlusive disease.

Journal Article Chest · January 1998 Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of ... Full text Link to item Cite

Simultaneous biplane coronary and pulmonary arteriography: a novel technique for defining the course of an anomalous left main coronary artery originating from the right sinus of Valsalva.

Journal Article Cathet Cardiovasc Diagn · September 1997 We present a novel technique employing biplane cineangiography with simultaneous left coronary and pulmonary angiography to define the anomalous course of the left main coronary artery when it originates from the right sinus of Valsalva. These biplane cine ... Full text Link to item Cite

Long-term echocardiographic assessment of restenosis after balloon mitral commissurotomy

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

The effect of balloon mitral commissurotomy on atrial rhythm

Journal Article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 1997 Link to item Cite

Balloon aortic valvuloplasty.

Journal Article Prog Cardiovasc Dis · 1997 Balloon aortic valvuloplasty is a percutaneous, therapeutic option for patients with severe aortic stenosis, yet the effectiveness of this procedure is dependent on the morphology of the stenotic aortic valve and the respective mechanism of dilation. In yo ... Full text Link to item Cite

Balloon aortic valvuloplasty: Failure to improve long-term survival for the elderly

Journal Article Cardiology Review · December 1, 1996 In this study of 165 elderly patients with severe symptomatic aortic valve stenosis treated with balloon valvuloplasty, long-term event-free and actuarial survival was poor regardless of symptoms at presentation and resembled the natural history of untreat ... Cite

Outcomes in patients treated with multiple coronary stents

Journal Article CIRCULATION · October 15, 1996 Link to item Cite

Toxicity of L-proline toward rat hippocampal neurons.

Journal Article Brain Res · July 19, 1988 Intrahippocampal injections of L-proline, a neutral amino acid excitant, non-selectively destroyed pyramidal and granule cells. Co-administration of equimolar kynurenate, an excitatory amino acid antagonist, markedly reduced the extent of neuronal cell dea ... Full text Link to item Cite

Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.

Journal Article Eur J Pharmacol · November 4, 1986 L-[3H]Proline binds specifically and saturably to rat hippocampal synaptic membranes in the absence of inorganic ions. Saturation isotherms constructed in Hepes-Tris buffer best fit a model of a single independent population of binding sites with a dissoci ... Full text Link to item Cite

Binding sites for L-[3H]glutamate on hippocampal synaptic membranes: three populations differentially affected by chloride and calcium ions.

Journal Article J Neurochem · June 1985 The effects of Cl- and Ca2+ were studied on the specific binding of L-[3H]glutamate to multiple sites on rat hippocampal synaptic membranes. Quisqualate (5 microM) or DL-2-amino-4-phosphonobutyrate (2-APB) (300 microM) was used to discriminate two previous ... Full text Link to item Cite