Journal ArticleEur Heart J · December 16, 2024
BACKGROUND AND AIMS: Long-term safety and efficacy of mavacamten in patients with obstructive hypertrophic cardiomyopathy (HCM) are unknown. MAVA-LTE (NCT03723655) is an ongoing, 5-year, open-label extension study designed to evaluate the long-term effects ...
Full textLink to itemCite
Journal ArticleJ Card Fail · December 7, 2024
BACKGROUND AND AIMS: In patients with symptomatic, obstructive hypertrophic cardiomyopathy (HCM), it is unclear if response to cardiac myosin inhibition varies with older age or a longer duration of diagnosis. This study evaluated the response of these sub ...
Full textLink to itemCite
Journal ArticleCirculation · November 18, 2024
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), VALOR-HCM trial (Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive HCM Who Are Eligible for Septal Reduction Therapy [URL: https://clinicaltr ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · November 5, 2024
BACKGROUND: Standard-of-care (SoC) medications for the treatment of obstructive hypertrophic cardiomyopathy (oHCM) are recommended as first-line therapy despite the lack of evidence from controlled clinical trials and well known off-target side effects. OB ...
Full textLink to itemCite
Journal ArticleJ Card Fail · September 28, 2024
BACKGROUND: In order to identify candidacy and treatment response for patients with obstructive hypertrophic cardiomyopathy (oHCM), clinicians need an accurate means of assessing symptoms, function, and quality of life. While the New York Heart Association ...
Full textLink to itemCite
Journal ArticleJACC Cardiovasc Imaging · September 2, 2024
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy (HCM), the VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Imaging · September 2024
BACKGROUND: In severely symptomatic patients with obstructive hypertrophic cardiomyopathy, VALOR-HCM (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) demonstra ...
Full textLink to itemCite
Journal ArticleJ Am Heart Assoc · April 16, 2024
BACKGROUND: The phase 2 PIONEER-HCM (Phase 2 Open-label Pilot Study Evaluating Mavacamten in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction) study showed that mavacamten improved left ventricular outflo ...
Full textLink to itemCite
Journal ArticleJACC Heart Fail · March 2024
BACKGROUND: Hypertension (HTN) is common in patients with hypertrophic cardiomyopathy (HCM), but its effect on the treatment of left ventricular outflow tract (LVOT) obstruction is undefined. Although elevated systolic blood pressure (SBP) may impact dynam ...
Full textLink to itemCite
Journal ArticleCirculation · February 13, 2024
BACKGROUND: Compared with men, women with hypertrophic cardiomyopathy (HCM) have a higher incidence of heart failure and worse outcomes. We investigated baseline clinical and echocardiographic characteristics and response to mavacamten among women compared ...
Full textLink to itemCite
Journal ArticleJAMA Cardiol · October 1, 2023
IMPORTANCE: There is an unmet need for novel medical therapies before recommending invasive therapies for patients with severely symptomatic obstructive hypertrophic cardiomyopathy (HCM). Mavacamten has been shown to improve left ventricular outflow tract ...
Full textLink to itemCite
Journal ArticleJACC Adv · October 2023
BACKGROUND: Artificial intelligence (AI) applied to 12-lead electrocardiographs (ECGs) can detect hypertrophic cardiomyopathy (HCM). OBJECTIVES: The purpose of this study was to determine if AI-enhanced ECG (AI-ECG) can track longitudinal therapeutic respo ...
Full textLink to itemCite
Journal ArticleJ Am Heart Assoc · August 15, 2023
Background There is uncertainty about the appropriate use of primary prevention implantable cardioverter-defibrillators (ICDs) among older patients with hypertrophic cardiomyopathy. Methods and Results Patients with hypertrophic cardiomyopathy who received ...
Full textLink to itemCite
Journal ArticleAm Heart J · June 2023
BACKGROUND: Limited data exists regarding the relationships between resource use and outcomes in patients with mitral regurgitation (MR). We examined resource utilization and outcomes across MR type and severity. METHODS: Using the Duke Echocardiography La ...
Full textLink to itemCite
Journal ArticleEur Heart J · June 1, 2023
AIMS: Severe tricuspid regurgitation (TR) exhibits high 1-year morbidity and mortality, yet long-term cardiovascular risk overall and by subgroups remains unknown. This study characterizes 5-year outcomes and identifies distinct clinical risk profiles of s ...
Full textLink to itemCite
Journal ArticleCirculation · March 14, 2023
BACKGROUND: Septal reduction therapy (SRT) in patients with intractable symptoms from obstructive hypertrophic cardiomyopathy (oHCM) is associated with variable morbidity and mortality. The VALOR-HCM trial (A Study to Evaluate Mavacamten in Adults with Sym ...
Full textLink to itemCite
Journal ArticleJAMA Cardiol · March 1, 2023
IMPORTANCE: Mavacamten, a cardiac myosin inhibitor, improved peak oxygen uptake (pVO2) in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in the EXPLORER-HCM study. However, the full extent of mavacamten's effects on exercise perfor ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · February 14, 2023
BACKGROUND: The impact of transcatheter edge-to-edge repair (TEER) on national surgical mitral valve repair (MVr) volume and outcomes is unknown. OBJECTIVES: This study aims to assess the impact of TEER availability on MVr volumes and outcomes for degenera ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · January 3, 2023
BACKGROUND: Left ventricular outflow tract (LVOT) obstruction is a major determinant of heart failure symptoms in obstructive hypertrophic cardiomyopathy (oHCM). Aficamten, a next-in-class cardiac myosin inhibitor, may lower gradients and improve symptoms ...
Full textLink to itemCite
Journal ArticleProg Cardiovasc Dis · 2023
Hypertrophic cardiomyopathy (HCM) is predominantly an autosomal dominant genetic heart disease with an estimated prevalence of 1 in 200 to 1 in 500 in the general population. Clinical manifestations of HCM vary from asymptomatic state to mild functional in ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Imaging · December 2022
BACKGROUND: In the randomized phase 3 VALOR-HCM study (A Study to Evaluate Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Who Are Eligible for Septal Reduction Therapy) of patients with obstructive hypertrophic cardiomyopathy ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · October 2022
BACKGROUND: Concerns regarding long-term durability of surgical repair for functional mitral regurgitation are based on short-term data, with few comparisons of ischemic mitral regurgitation (IMR) versus nonischemic functional mitral regurgitation (NIFMR) ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Imaging · September 2022
Mitral annular disjunction is increasingly recognized as an important anatomic feature of mitral valve disease. The presence of mitral annular disjunction, defined as separation between the left atrial wall at the point of mitral valve insertion and the le ...
Full textLink to itemCite
Journal ArticleCirc Heart Fail · September 2022
BACKGROUND: Hypertrophic cardiomyopathy (HCM)-related mortality has been decreasing within the United States; however, persistent disparities in demographic subsets may exist. In this study, we assessed nationwide trends in mortality related to HCM among p ...
Full textLink to itemCite
Journal ArticleBMC Cardiovasc Disord · July 29, 2022
BACKGROUND: Valve surgery guidelines for infective endocarditis (IE) are unchanged over decades and nationwide data about the use of valve surgery do not exist. METHODS: We included patients with first-time IE (1999-2018) using Danish nationwide registries ...
Full textLink to itemCite
Journal ArticleEur Heart J · May 1, 2022
Surgery is an effective therapy in the treatment of left-sided infective endocarditis (IE) in patients for whom antibiotic treatment alone is unlikely to be curative or may be associated with ongoing risk of complications. However, the interplay between in ...
Full textLink to itemCite
Journal ArticleJ Card Surg · February 2022
BACKGROUND: The durability of surgical repair for degenerative versus ischemic mitral regurgitation (MR) is thought to be markedly different. We, therefore, examined late outcomes and durability for mitral repair in a large cohort of patients receiving a s ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · December 21, 2021
BACKGROUND: EXPLORER-HCM (Clinical Study to Evaluate Mavacamten [MYK-461] in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy) demonstrated that mavacamten, a cardiac myosin inhibitor, improves symptoms, exercise capacity, and left ventricul ...
Full textLink to itemCite
Journal ArticleJAMA Netw Open · January 4, 2021
IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ...
Full textLink to itemCite
Journal ArticleLancet · September 12, 2020
BACKGROUND: Cardiac muscle hypercontractility is a key pathophysiological abnormality in hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (LVOT) obstruction. Available pharmacological options for hypertrophic c ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · August 18, 2020
BACKGROUND: Monogenic diseases are individually rare but collectively common, and are likely underdiagnosed. OBJECTIVES: The purpose of this study was to estimate the prevalence of monogenic cardiovascular diseases (MCVDs) and potentially missed diagnoses ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · June 2, 2020
BACKGROUND: Patients with nonobstructive hypertrophic cardiomyopathy (nHCM) often experience a high burden of symptoms; however, there are no proven pharmacological therapies. By altering the contractile mechanics of the cardiomyocyte, myosin inhibitors ha ...
Full textLink to itemCite
Journal ArticleAm Heart J · June 2020
BACKGROUND: Patients with bicuspid aortic valve stenosis (BAV) were excluded from all the trileaflet aortic valve stenosis (TAV) pivotal trials, and therefore, their outcomes are not clearly defined. The aim of the study was to evaluate the outcomes of tra ...
Full textLink to itemCite
Journal ArticleCirc Heart Fail · June 2020
BACKGROUND: Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by unexplained left ventricular (LV) hypertrophy associated with dynamic LV outflow tract obstruction. Current medical therapies are nonspecific and have limited efficacy in reliev ...
Full textLink to itemCite
Journal ArticleJACC Cardiovasc Interv · December 9, 2019
OBJECTIVES: The aim of this study was to assess the real-world impact of transcatheter mitral valve repair (TMVR) on hospitalizations and Medicare costs pre- versus post-TMVR. BACKGROUND: TMVR is effective in degenerative mitral regurgitation (MR) and appr ...
Full textLink to itemCite
ConferenceEur Heart J · July 14, 2019
AIMS: In left-sided infective endocarditis (IE), a large vegetation >10 mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the associ ...
Full textLink to itemCite
Journal ArticleJ Invasive Cardiol · July 2019
BACKGROUND: Alternative access (AA) is still required for a significant proportion of patients undergoing transcatheter aortic valve replacement (TAVR). We sought to compare the clinical outcomes of patients undergoing AA vs transfemoral (TF) access. METHO ...
Link to itemCite
Journal ArticleAnn Intern Med · June 4, 2019
BACKGROUND: Mavacamten, an orally administered, small-molecule modulator of cardiac myosin, targets underlying biomechanical abnormalities in obstructive hypertrophic cardiomyopathy (oHCM). OBJECTIVE: To characterize the effect of mavacamten on left ventri ...
Full textLink to itemCite
Journal ArticleAm Heart J · April 2019
BACKGROUND: In patients with active infective endocarditis (IE), the relationship between timing of surgery and survival is uncertain. The objective was to evaluate clinical characteristics associated with timing of surgery and the association between surg ...
Full textLink to itemCite
Journal ArticleInt J Cardiol · March 1, 2019
BACKGROUND: Long duration of diabetes mellitus (DM) is associated with an increased risk of infection, however no studies have yet focused on the duration of DM and the associated risk of infective endocarditis (IE). METHODS: Patients with DM were identifi ...
Full textLink to itemCite
Journal ArticleCirculation · January 2, 2019
BACKGROUND: Secondary mitral regurgitation (SMR) occurs in the absence of organic mitral valve disease and may develop as the left ventricle dilates or remodels or as a result of leaflet tethering with impaired coaptation, most commonly from apical and lat ...
Full textLink to itemCite
Journal ArticleAm Heart J · September 2018
BACKGROUND: We aimed to determine the association of MR severity and type with all-cause death in a large, real-world, clinical setting. METHODS: We reviewed full echocardiography studies at Duke Echocardiography Laboratory (01/01/1995-12/31/2010), classif ...
Full textLink to itemCite
Journal ArticleJAMA · July 3, 2018
IMPORTANCE: Infective endocarditis occurs in approximately 15 of 100 000 people in the United States and has increased in incidence. Clinicians must make treatment decisions with respect to prophylaxis, surgical management, specific antibiotics, and the le ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · April 2018
BACKGROUND: Outcome of mitral valve replacement in extreme scenarios of small mitral annulus with the use of the Regent mechanical aortic valve is not well documented. METHODS: Records were examined in 31 consecutive patients who underwent mitral valve rep ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Heart Valve Dis · November 2017
The modified Ross procedure, which involves replacement of the aortic valve with a pulmonary autograft root supported within a Dacron tube graft, was developed with the goal of preventing late autograft dilatation and associated aortic insufficiency. The c ...
Link to itemCite
Journal ArticleClin Microbiol Infect · August 2017
OBJECTIVES: Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is ≥1.5 mg/L. We aimed to validate this using the Internatio ...
Full textOpen AccessLink to itemCite
Journal ArticleAm Heart J · July 2017
UNLABELLED: MitraClip is an approved therapy for mitral regurgitation (MR); however, health care resource utilization pre- and post-MitraClip remains understudied. METHODS: Patients with functional and degenerative MR at high surgical risk in the EVEREST I ...
Full textLink to itemCite
Journal ArticleCurr Cardiol Rep · July 2016
Since publication of the 2011 American College of Cardiology Foundation (ACCF) and American Heart Association (AHA) Guideline for the diagnosis and treatment of hypertrophic cardiomyopathy (HCM), more recent studies offer greater insights about this condit ...
Full textLink to itemCite
Journal ArticleJ Card Surg · May 2016
BACKGROUND: Transcatheter valve-in-valve (VIV) procedures are an alternative to standard surgical valve replacement in high risk patients. METHODS: Cases in which a commercially approved transcatheter aortic valve replacement (TAVR) device was used for a n ...
Full textLink to itemCite
Journal ArticleJ Am Heart Assoc · April 18, 2016
BACKGROUND: Host factors and complications have been associated with higher mortality in infective endocarditis (IE). We sought to develop and validate a model of clinical characteristics to predict 6-month mortality in IE. METHODS AND RESULTS: Using a lar ...
Full textLink to itemCite
Journal ArticleJ Am Soc Echocardiogr · April 2016
BACKGROUND: In patients with suspected native valve infective endocarditis, current guidelines recommend initial transthoracic echocardiography (TTE) followed by transesophageal echocardiography (TEE) if clinical suspicion remains. The guidelines do not ac ...
Full textLink to itemCite
Journal ArticleJ Intensive Care Med · March 2016
Infective endocarditis (IE) is a noncontagious infection of the endocardium and heart valves. The epidemiology of IE has shifted recently with an increase in health care-associated IE. Infective endocarditis requiring intensive care unit stay is increasing ...
Full textLink to itemCite
Journal ArticleAm Heart J · February 2016
BACKGROUND: The revised 2014 American College of Cardiology (ACC)/American Heart Association valvular heart disease guidelines provide evidenced-based recommendations for the management of mitral regurgitation (MR). However, knowledge gaps related to our e ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · December 29, 2015
BACKGROUND: In EVEREST II (Endovascular Valve Edge-to-Edge Repair Study), treatment of mitral regurgitation (MR) with a novel percutaneous device showed superior safety compared with surgery, but less effective reduction in MR at 1 year. OBJECTIVES: This s ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · December 2015
Carcinoid tumors rarely metastasize to the heart, and previous reports involved the myocardium only. We present a case of carcinoid tumor metastatic to the right ventricle (RV) and tricuspid valve. Preoperative cardiac magnetic resonance imaging (CMR) show ...
Full textLink to itemCite
Journal ArticleEur Heart J · October 21, 2015
AIMS: The management and outcomes of patients with functional moderate/severe mitral regurgitation and severe left ventricular (LV) systolic dysfunction are not well defined. We sought to determine the characteristics, management strategies, and outcomes o ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · July 2015
Over the last decade, transcatheter aortic valve replacement (TAVR) has emerged as an effective treatment for inoperable and selected high surgical-risk patients with aortic stenosis. However, management of procedural complications with TAVR represents a m ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · June 1, 2015
This study sought to compare the accuracy of 2-dimensional transesophageal echocardiography (TEE) and computed tomography angiography (CTA) for noninvasive aortic annular sizing as required for transcatheter aortic valve implantation (TAVI). Direct intraop ...
Full textLink to itemCite
Journal ArticleAntimicrob Agents Chemother · April 2015
Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · April 2015
We describe the use of transcatheter aortic valve replacement to allow for bridging to a left ventricular assist device in a patient with end-stage heart failure, secondary to nonischemic cardiomyopathy and severe bioprosthetic aortic valve regurgitation. ...
Full textLink to itemCite
Journal ArticleClin Infect Dis · March 1, 2015
BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ...
Full textLink to itemCite
Journal ArticlePulm Circ · March 2015
Diabetes complicates management in a number of disease states and adversely impacts survival; how diabetes affects patients with pulmonary hypertension (PH) has not been well characterized. With insulin resistance having recently been demonstrated in PH, w ...
Full textOpen AccessLink to itemCite
Journal ArticleInt J Cardiol · January 15, 2015
BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ...
Full textLink to itemCite
Journal ArticleCirculation · January 13, 2015
BACKGROUND: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) ...
Full textLink to itemCite
Journal ArticleJ Comput Assist Tomogr · 2015
PURPOSE: This study aimed to assess vascular contrast opacification and homogeneity using single-bolus contrast administration with hybrid thoracic and abdominopelvic computed tomographic angiography in patients with severe aortic valve stenosis. MATERIALS ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Interv · January 2015
BACKGROUND: Chronic kidney disease (CKD) is strongly related to outcome in cardiovascular diseases. The relationship between treatment of mitral regurgitation (MR) and renal function is not well described. We sought to evaluate renal function before and af ...
Full textLink to itemCite
Chapter · November 1, 2014
Infective endocarditis is defined as infection of a heart valve or other cardiac tissue. This diagnosis has broadened beyond infections involving native cardiac tissue or prosthetic heart valves to include infections of implanted intracardiac devices. Desp ...
Full textCite
Journal ArticleJ Am Coll Cardiol · July 15, 2014
BACKGROUND: Surgical mitral valve repair (SMVR) remains the gold standard for severe degenerative mitral regurgitation (DMR). However, the results with transcatheter mitral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously repor ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · June 1, 2014
Despite advances in the treatment of aortic stenosis (AS), many patients with AS remain untreated. Barriers to accessing cardiovascular surgical care may play a role in this undertreatment. We sought to examine whether there are geographic variations in th ...
Full textLink to itemCite
Journal ArticleJAMA Intern Med · September 9, 2013
IMPORTANCE: There are limited prospective, controlled data evaluating survival in patients receiving early surgery vs medical therapy for prosthetic valve endocarditis (PVE). OBJECTIVE: To determine the in-hospital and 1-year mortality in patients with PVE ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · July 23, 2013
OBJECTIVES: This study sought to evaluate 4-year outcomes of percutaneous repair versus surgery for mitral regurgitation. BACKGROUND: Transcatheter therapies are being developed to treat valvular heart disease. In the EVEREST (Endovascular Valve Edge-to-Ed ...
Full textLink to itemCite
Journal ArticleCatheter Cardiovasc Interv · July 1, 2013
Invasive hemodynamic evaluation in the patient with a mechanical aortic valve has in the past required transseptal or apical left ventricular puncture in order to obtain left ventricular pressure measurements. Over the last few years, several case reports ...
Full textLink to itemCite
Journal ArticleQual Life Res · April 2013
BACKGROUND: Dyspnea and the resulting functional impairment are a common complication in hypertrophic cardiomyopathy (HCM). The relationship between physician-perceived functional status, patient-perceived health status, and objective exercise test results ...
Full textLink to itemCite
Journal ArticleClin Infect Dis · January 2013
BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ...
Full textLink to itemCite
Journal ArticlePLoS One · 2013
The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ...
Full textLink to itemCite
Journal ArticleJAMA · April 25, 2012
Featured Publication
CONTEXT: Infection of implantable cardiac devices is an emerging disease with significant morbidity, mortality, and health care costs. OBJECTIVES: To describe the clinical characteristics and outcome of cardiac device infective endocarditis (CDIE) with att ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · April 3, 2012
Featured Publication
OBJECTIVES: The purpose of this study was to characterize patients with mitral regurgitation (MR) and atrial fibrillation (AF) treated percutaneously using the MitraClip device (Abbott Vascular, Abbott Park, Illinois) and compare the results with surgery i ...
Full textLink to itemCite
Journal ArticleJ Thorac Cardiovasc Surg · April 2012
OBJECTIVE: The Endovascular Valve Edge-to-Edge Repair Study (EVEREST II) is a prospective, multicenter, randomized controlled trial comparing percutaneous repair with the MitraClip device to mitral valve (MV) surgery in the treatment of mitral regurgitatio ...
Full textLink to itemCite
Journal ArticleCurr Treat Options Cardiovasc Med · December 2011
Our approach to the management of the patient with a bicuspid aortic valve (BAV) takes several factors into consideration. First, is the dysfunction of the valve due to aortic stenosis (AS), aortic regurgitation (AR), or a combination of stenosis and regur ...
Full textLink to itemCite
Journal ArticleCurr Treat Options Cardiovasc Med · December 2011
Infective endocarditis is an uncommon cardiac condition but is associated with significant morbidity and mortality despite advancements in diagnosis and treatment. Recent epidemiologic changes in this disease have resulted in additional challenges for trea ...
Full textLink to itemCite
Journal ArticleJAMA · November 23, 2011
Featured Publication
CONTEXT: Heart failure (HF) is the most common complication of infective endocarditis. However, clinical characteristics of HF in patients with infective endocarditis, use of surgical therapy, and their associations with patient outcome are not well descri ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · November 22, 2011
Featured Publication
OBJECTIVES: The purpose of the study is to identify the predictors of clinical outcome (mortality and survival without repeat septal reduction procedures) of alcohol septal ablation for the treatment of patients with hypertrophic obstructive cardiomyopathy ...
Full textLink to itemCite
Journal ArticleInt J Cardiol · August 4, 2011
BACKGROUND: Anemia is a marker of worsened clinical outcome in patients with heart failure from left ventricular dysfunction. Pulmonary hypertension often results in right ventricular dysfunction. Accordingly we sought to examine the association of hemoglo ...
Full textOpen AccessLink to itemCite
Journal ArticleAm J Cardiol · August 1, 2011
Troponin levels have been correlated with adverse outcomes in multiple disease processes, including congestive heart failure, acute coronary syndromes, sepsis, and, in a few small series, infective endocarditis. We hypothesized that a novel measurement of ...
Full textLink to itemCite
Journal ArticleJ Heart Valve Dis · July 2011
BACKGROUND AND AIM OF THE STUDY: Bicuspid aortic valve (BAV) disease is associated with an aortopathy resulting in aneurysmal dilatation spanning the root, ascending, and arch segments. To date, no large series of proximal aortic replacement in this popula ...
Link to itemCite
Journal ArticleJ Card Fail · April 2011
OBJECTIVE: To examine the ability of vasodilator response to predict survival in a diverse cohort of patients with pulmonary hypertension (PH). PATIENTS & METHODS: A total of 214 consecutive treatment-naive patients referred for invasive PH evaluation were ...
Full textOpen AccessLink to itemCite
Journal ArticleEur J Echocardiogr · February 2011
UNLABELLED: Aim The presence of septal hypertrophy in hypertrophic cardiomyopathy (HCM) is common. To date, there has been no accepted classification of septal morphology in HCM. Furthermore, the possible relationship between septal morphology and clinical ...
Full textLink to itemCite
Journal ArticleJ Invasive Cardiol · January 2011
Coronary artery anomalies arising from the pulmonary artery are rare, result in reversed flow in the affected coronary artery, and are commonly associated with myocardial ischemia in infancy or childhood. Uncorrected survival to adult age is rare. We prese ...
Link to itemCite
Journal ArticleJ Heart Valve Dis · November 2010
BACKGROUND AND AIM OF THE STUDY: Pulmonary hypertension frequently complicates mitral stenosis, with a subset of these patients exhibiting pressures well in excess of their mitral valve hemodynamics. The prevalence of this condition and its impact on clini ...
Open AccessLink to itemCite
Journal ArticleAm J Cardiol · October 1, 2010
Elevated B-type natriuretic peptide (BNP) is a marker of poor outcomes in heart failure, acute coronary syndromes, and sepsis. Elevated cardiac troponin I (cTnI) is associated with adverse outcomes in infective endocarditis. It was hypothesized that elevat ...
Full textLink to itemCite
Journal ArticleEur J Clin Microbiol Infect Dis · October 2010
Referral bias occurs because of the clustering of patients at tertiary care centers. This may result in the distortion of observed clinical manifestations of rare diseases. This analysis evaluates the effect of referral bias on the epidemiology of infectiv ...
Full textLink to itemCite
Journal ArticleAnn Intern Med · September 7, 2010
Featured Publication
Surgical aortic valve replacement (SAVR) is the only treatment known to improve symptoms and survival in patients with severe, symptomatic aortic stenosis. Perioperative mortality, however, is high among many patients for whom SAVR may be indicated. Percut ...
Full textLink to itemCite
Journal ArticleCirc Cardiovasc Interv · April 2010
Featured Publication
BACKGROUND: Septal reduction for obstructive hypertrophic cardiomyopathy may be performed by surgical myectomy or alcohol septal ablation (ASA). Unlike surgical myectomy, ASA creates an intramyocardial scar that may potentiate the risk of ventricular arrhy ...
Full textLink to itemCite
Journal ArticleCirculation · March 2, 2010
Featured Publication
BACKGROUND: The impact of early surgery on mortality in patients with native valve endocarditis (NVE) is unresolved. This study sought to evaluate valve surgery compared with medical therapy for NVE and to identify characteristics of patients who are most ...
Full textOpen AccessLink to itemCite
Journal ArticleJ Heart Valve Dis · May 2009
BACKGROUND AND AIM OF THE STUDY: Pure annular dilation (PAD) is a recognized etiology of mitral regurgitation, yet few data exist to define the prognostic profile of this disorder relative to other etiologies, such as ischemia or myxomatous prolapse. METHO ...
Link to itemCite
Journal ArticleArch Intern Med · March 9, 2009
Featured Publication
BACKGROUND: We sought to provide a contemporary picture of the presentation, etiology, and outcome of infective endocarditis (IE) in a large patient cohort from multiple locations worldwide. METHODS: Prospective cohort study of 2781 adults with definite IE ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · February 1, 2009
Many patients with systolic dysfunction undergo elective percutaneous coronary intervention (PCI) despite the unknown risk and limited data supporting its use. Therefore, the aim of this study was to evaluate the association between the severity of left ve ...
Full textLink to itemCite
Chapter · January 20, 2009
"--JAMA Part of the Pediatric Practice series, Pediatric Practice: Infectious Diseases is filled with practical, clinically relevant guidance for successful infectious disease management. ...
Cite
Journal ArticleIndian Heart J · 2009
Rheumatic Heart Disease (RHD) is well known to be an active inflammatory process which develops progressive calcification and leaflet thickening over time. The potential for statin therapy in slowing the progression of valvular heart disease is still contr ...
Link to itemCite
Journal ArticleEuroIntervention · January 2009
AIMS: Percutaneous repair of mitral regurgitation (MR) by leaflet apposition using a clip deployed via transseptal catheterisation is undergoing evaluation. METHODS AND RESULTS: In order to detect the potential for clinically significant left ventricular i ...
Full textLink to itemCite
Journal ArticleNew England Journal of Medicine · December 4, 2008
A 25-year-old woman with a history of depression, mitral-valve prolapse, and migraine headaches presented to a hospital emergency department with a 3-day history of subjective fever, diffuse arthralgia, and a severe generalized headache that was not charac ...
Cite
Journal ArticleHeart · May 2008
BACKGROUND: Despite widespread acceptance of echocardiography for diagnosis of infective endocarditis, few investigators have evaluated its utility as a risk-stratification tool to aid therapeutic decision-making. METHODS: A decision tree and Markov analys ...
Full textLink to itemCite
Journal ArticleAnn Intern Med · December 18, 2007
BACKGROUND: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, ...
Full textLink to itemCite
Journal ArticleJAMA · March 28, 2007
Featured Publication
CONTEXT: Prosthetic valve endocarditis (PVE) is associated with significant mortality and morbidity. The contemporary clinical profile and outcome of PVE are not well defined. OBJECTIVES: To describe the prevalence, clinical characteristics, and outcome of ...
Full textLink to itemCite
Journal ArticleClin Infect Dis · February 1, 2007
Featured Publication
BACKGROUND: An accurate assessment of the predictors of long-term mortality in patients with infective endocarditis is not possible using retrospective data because of inherent treatment biases and predictable imbalances in the distribution of prognostic f ...
Full textLink to itemCite
Journal ArticleJ Matern Fetal Neonatal Med · September 2006
BACKGROUND: Pregnancy in a woman with a mechanical heart valve is a life-threatening situation. Due to the inability of unfractionated heparin to prevent valvular thromboses, warfarin or other vitamin K antagonists have been the preferred anticoagulants fo ...
Full textLink to itemCite
Journal ArticleJ Heart Valve Dis · May 2006
BACKGROUND AND AIM OF THE STUDY: Inflammation may play a central role in the progression of stenotic valvular heart disease. Serum levels of matrix metalloproteinases (MMPs), markers of extracellular matrix (ECM) turnover and potential markers of active in ...
Link to itemCite
OtherScand J Infect Dis · 2006
The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on End ...
Full textLink to itemCite
Journal ArticleAm Heart J · November 2005
Featured Publication
BACKGROUND: Early surgery has been shown to be beneficial for patients with infective endocarditis (IE), yet surgery is not used in most patients. Evidence of the uncertainty around the use of surgery can be found in the wide variations in the use of cardi ...
Full textLink to itemCite
Journal ArticleAm Heart J · November 2005
Featured Publication
BACKGROUND: Although surgical intervention is often used in the treatment of prosthetic valve infective endocarditis (PVIE), an understanding of its effect on survival has been limited by the biases of observational studies and lack of controlled trials. M ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · October 1, 2005
The aims of this study were to determine the clinical characteristics and outcome of patients who had definite infective endocarditis (IE) complicated by aortic ring abscess formation that was detected with transesophageal echocardiography (TEE) and to det ...
Full textLink to itemCite
Journal ArticleAm Heart J · October 2005
BACKGROUND: Assessment of pulmonary vasodilator responsiveness is important in determining the prognosis and management of patients with pulmonary hypertension. Many patients, however, are already on vasodilators at the time of testing. It is unclear if th ...
Full textLink to itemCite
Journal ArticleAm J Med · March 2005
PURPOSE: Staphylococcus aureus is a common cause of bacteremia and of native valve infective endocarditis. However, the risk of endocarditis in patients with a prosthetic valve who develop S. aureus bacteremia is unclear. The aim of this study was to defin ...
Full textLink to itemCite
Journal ArticleCurr Treat Options Cardiovasc Med · December 2004
Infective endocarditis (IE) is a serious and deadly disease. Despite medical advances over the past half century, more than one half of patients with IE suffer a serious complication, and the mortality rate remains approximately 20% during the initial hosp ...
Full textLink to itemCite
Journal ArticleCirculation · April 13, 2004
Featured Publication
BACKGROUND: Data on early determinants of outcome in infective endocarditis (IE) are limited. We evaluated the prognostic significance of early clinical characteristics in a large, prospective cohort of patients with IE. METHODS AND RESULTS: Two hundred si ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · April 1, 2004
A prospective cohort of patients with mitral stenosis and no history of atrial arrhythmias showed no decrease in the incidence of atrial fibrillation (AF) after successful versus unsuccessful Inoue balloon percutaneous balloon mitral valve commissurotomy. ...
Full textLink to itemCite
Journal ArticleAnn Thorac Surg · March 2004
Coronary artery fistulas (CAF) are rare abnormalities that can be symptomatic or asymptomatic. Most drain into the right ventricle or pulmonary artery, though a variety of other drainage sites have been reported. We report the results of the surgical closu ...
Full textLink to itemCite
Journal ArticleAm Heart J · February 2004
BACKGROUND: The late outcome of patients treated with atrial septal occluder devices remains incompletely defined. The purpose of this study was to assess the late outcome (range 4-7 years postprocedure) of patients in whom the Das AngelWings septal occlud ...
Full textLink to itemCite
Journal ArticleAm Heart J · December 2003
BACKGROUND: Markers of systemic inflammation including C-reactive protein (CRP) appear to predict morbidity and mortality in various clinical conditions. The presence of systemic inflammation and its impact on the procedural success of percutaneous balloon ...
Full textLink to itemCite
Journal ArticleJAMA · November 5, 2003
Featured Publication
CONTEXT: The development of contrast-induced nephropathy in patients undergoing invasive cardiac procedures is associated with a marked increase in cardiovascular morbidity and mortality. Fenoldopam mesylate, a specific agonist of the dopamine-1 receptor, ...
Full textLink to itemCite
Journal ArticleCatheter Cardiovasc Interv · June 2003
Using a prospectively collected database of patients undergoing cardiac catheterization, we sought to compare the outcomes of procedures performed by supervised physician assistants (PAs) with those performed by supervised cardiology fellows-in-training. O ...
Full textLink to itemCite
Journal ArticleJ Heart Valve Dis · March 2003
Featured Publication
BACKGROUND AND AIM OF THE STUDY: The pulmonary autograft, or Ross procedure, has theoretical hemodynamic benefits over other aortic valve replacements. The hemodynamic performance of the pulmonary autograft and pulmonary homograft components of this proced ...
Link to itemCite
Journal ArticleAm J Cardiovasc Drugs · 2003
Contrast-induced nephropathy occurs in 2-10% of patients exposed to intravascular radiographic contrast agents and results in significant morbidity and mortality. Although the exact mechanism of this disorder has not been fully elucidated, contrast nephrop ...
Full textLink to itemCite
Journal ArticleAm Heart J · May 2002
Featured Publication
BACKGROUND: Radiocontrast nephropathy (RCN) is a common source of acute renal failure in hospitalized patients and is associated with increased morbidity and mortality rates. Fenoldopam mesylate is a dopamine A1 receptor agonist that augments renal plasma ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · January 16, 2002
OBJECTIVES: This study was designed to determine predictors of restenosis after successful percutaneous mitral commissurotomy (PMC) and its relationship to late clinical outcome. BACKGROUND: The restenosis rate after PMC and its relationship to late clinic ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · November 1, 2001
Percutaneous balloon mitral commissurotomy (PBMC) is now first-line therapy in patients with symptomatic mitral stenosis (MS) and favorable valve morphology. Unfortunately, the outcome of Medicare-aged patients undergoing this procedure has not previously ...
Full textLink to itemCite
Journal ArticleAm Heart J · August 2001
BACKGROUND: Cardiac conduction abnormalities occur in endocarditis and have been associated with infection extension and increased mortality. There have been no prospective studies of electrocardiographic (ECG) conduction changes in endocarditis. We examin ...
Full textLink to itemCite
Journal ArticleJ Am Soc Echocardiogr · April 2001
An association between left atrial spontaneous echocardiographic contrast (LASEC) and thromboembolic events has been recognized. However, the appearance of LASEC and the assessment of its intensity are gain dependent. To evaluate the relation between LASEC ...
Full textLink to itemCite
Journal ArticleJ Am Coll Cardiol · December 2000
OBJECTIVES: We sought to compare the responses of patients with pulmonary hypertension from primary and secondary causes (PPH and SPH, respectively) to inhaled nitric oxide (iNO) in the cardiac catheterization laboratory. BACKGROUND: Pulmonary hypertension ...
Full textLink to itemCite
Journal ArticleCatheter Cardiovasc Interv · December 2000
A 44-year-old woman with recurrent pulmonary infections developed severe hemoptysis. Chest radiography revealed a hypoplastic right lung. Absence of the right pulmonary artery, a very rare congenital anomaly, was demonstrated by computed tomography and car ...
Full textLink to itemCite
Journal ArticleKidney Int · April 2000
BACKGROUND: Endothelin is a potent vasoconstrictor that has been implicated in the pathogenesis of radiocontrast nephrotoxicity. Endothelin antagonists may reduce the renal hemodynamic abnormalities following radiocontrast administration. METHODS: One hund ...
Full textLink to itemCite
Journal ArticleAm Heart J · October 1999
BACKGROUND: This study evaluated the correlation and variability between noninvasive and invasive measures of mitral stenosis severity before and after balloon mitral commissurotomy (BMC) in a large group of patients with symptomatic mitral stenosis. Facto ...
Full textLink to itemCite
Journal ArticleCatheter Cardiovasc Interv · April 1999
We describe two unusual cases of hypoxemia after cardiac surgery due to intracardiac right-to-left shunting through a patent foramen ovale or atrial septal defect. The interatrial defects were successfully occluded by placement of a novel, transcather devi ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · January 1, 1999
Clinical, echocardiographic, and cardiac catheterization data were evaluated in 263 patients with mitral stenosis who were undergoing balloon commissurotomy to determine the predictors of atrial rhythm and its effect on functional status. Conversion from a ...
Full textLink to itemCite
Journal ArticleAm J Cardiol · December 1, 1998
Left atrial v-wave amplitude has been associated with the presence and severity of chronic mitral regurgitation (MR) but it has not been evaluated for the detection of acute MR. We evaluated the left atrial v-wave amplitude of 205 consecutive patients with ...
Full textLink to itemCite
Journal ArticleChest · January 1998
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension associated with fibrotic occlusion of the smaller pulmonary veins. Although vasodilator therapy is effective in many patients with primary pulmonary hypertension, the role of ...
Full textLink to itemCite
Journal ArticleCathet Cardiovasc Diagn · September 1997
We present a novel technique employing biplane cineangiography with simultaneous left coronary and pulmonary angiography to define the anomalous course of the left main coronary artery when it originates from the right sinus of Valsalva. These biplane cine ...
Full textLink to itemCite
Journal ArticleProg Cardiovasc Dis · 1997
Balloon aortic valvuloplasty is a percutaneous, therapeutic option for patients with severe aortic stenosis, yet the effectiveness of this procedure is dependent on the morphology of the stenotic aortic valve and the respective mechanism of dilation. In yo ...
Full textLink to itemCite
Journal ArticleCardiology Review · December 1, 1996
In this study of 165 elderly patients with severe symptomatic aortic valve stenosis treated with balloon valvuloplasty, long-term event-free and actuarial survival was poor regardless of symptoms at presentation and resembled the natural history of untreat ...
Cite
Journal ArticleBrain Res · July 19, 1988
Intrahippocampal injections of L-proline, a neutral amino acid excitant, non-selectively destroyed pyramidal and granule cells. Co-administration of equimolar kynurenate, an excitatory amino acid antagonist, markedly reduced the extent of neuronal cell dea ...
Full textLink to itemCite
Journal ArticleEur J Pharmacol · November 4, 1986
L-[3H]Proline binds specifically and saturably to rat hippocampal synaptic membranes in the absence of inorganic ions. Saturation isotherms constructed in Hepes-Tris buffer best fit a model of a single independent population of binding sites with a dissoci ...
Full textLink to itemCite
Journal ArticleJ Neurochem · June 1985
The effects of Cl- and Ca2+ were studied on the specific binding of L-[3H]glutamate to multiple sites on rat hippocampal synaptic membranes. Quisqualate (5 microM) or DL-2-amino-4-phosphonobutyrate (2-APB) (300 microM) was used to discriminate two previous ...
Full textLink to itemCite