Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.
Publication
, Journal Article
Greene, WM; Wang, A; Nadler, JV
Published in: Eur J Pharmacol
November 4, 1986
L-[3H]Proline binds specifically and saturably to rat hippocampal synaptic membranes in the absence of inorganic ions. Saturation isotherms constructed in Hepes-Tris buffer best fit a model of a single independent population of binding sites with a dissociation constant of 1.6 microM and maximum density of 16 pmol/mg protein. The rank order of displacement of radioligand by proline analogues suggests that binding sites of this type could be receptors responsible for proline-induced retinal spreading depression and inhibition of memory consolidation.
Duke Scholars
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
November 4, 1986
Volume
130
Issue
3
Start / End Page
333 / 336
Location
Netherlands
Related Subject Headings
- Synaptic Membranes
- Sodium
- Rats, Inbred Strains
- Rats
- Proline
- Pharmacology & Pharmacy
- Kinetics
- In Vitro Techniques
- Hippocampus
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Greene, W. M., Wang, A., & Nadler, J. V. (1986). Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol, 130(3), 333–336. https://doi.org/10.1016/0014-2999(86)90288-8
Greene, W. M., A. Wang, and J. V. Nadler. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.” Eur J Pharmacol 130, no. 3 (November 4, 1986): 333–36. https://doi.org/10.1016/0014-2999(86)90288-8.
Greene WM, Wang A, Nadler JV. Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol. 1986 Nov 4;130(3):333–6.
Greene, W. M., et al. “Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes.” Eur J Pharmacol, vol. 130, no. 3, Nov. 1986, pp. 333–36. Pubmed, doi:10.1016/0014-2999(86)90288-8.
Greene WM, Wang A, Nadler JV. Sodium-independent binding of L-[3H]proline to hippocampal synaptic membranes. Eur J Pharmacol. 1986 Nov 4;130(3):333–336.
Published In
Eur J Pharmacol
DOI
ISSN
0014-2999
Publication Date
November 4, 1986
Volume
130
Issue
3
Start / End Page
333 / 336
Location
Netherlands
Related Subject Headings
- Synaptic Membranes
- Sodium
- Rats, Inbred Strains
- Rats
- Proline
- Pharmacology & Pharmacy
- Kinetics
- In Vitro Techniques
- Hippocampus
- Female