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Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease.

Publication ,  Journal Article
Lima, B; Williams, JB; Bhattacharya, SD; Shah, AA; Andersen, N; Wang, A; Harrison, JK; Hughes, GC
Published in: The Journal of heart valve disease
July 2011

Bicuspid aortic valve (BAV) disease is associated with an aortopathy resulting in aneurysmal dilatation spanning the root, ascending, and arch segments. To date, no large series of proximal aortic replacement in this population has been reported. The study aim was to report contemporary surgical outcomes for proximal aortic replacement in BAV disease, and to examine the relationships between valve morphology, valve pathophysiology, and pathology of the thoracic aorta.Between September 2005 and December 2009, a total of 100 consecutive patients (mean age 54 +/- 13 years; range: 29-80 years) with BAV and proximal aortic enlargement underwent aortic replacement at a single referral institution. Of these patients, 16% had undergone prior aortic valve replacement (AVR). The aortic repair was individually tailored to treat the aortic valve and thoracic aortic pathology, and included supracoronary ascending aortic (AA) replacement (n = 17), AVR with separate supracoronary AA replacement (n = 39), aortic root replacement (n = 42), and valve-sparing root replacement (n = 2). Concomitant arch replacement was performed in 82 patients (80 hemi-arch, two full arch). Other concomitant cardiac procedures were performed in 28 patients.The 30-day/in-hospital rates of death and stroke were both 1%. The predominant aortic valve pathophysiology was aortic stenosis (AS; 33%), aortic insufficiency (AI; 29%), mixed AS/AI (17%), normally functioning BAV (17%), and unknown (4%). Valve morphology included Sievers Type I, R/L (75%), Type I, R/N (9%), Type I, L/N (2%), Type 0 (7%), and Type II (7%). BAV patients with predominantly AI had more frequent root dilatation (62%) than those with either AS (30%) or normal valve function (35%). Based on BAV morphology, there were no significant differences in maximal thoracic aortic diameters between groups. At a mean follow up of 16 months, there were no late deaths or valve-related complications.Proximal aortic replacement in patients with BAV can be performed with low rates of mortality and morbidity. The pathologic anatomy of the thoracic aorta was not predicted by the aortic valve morphology, although dilation of the aortic root was most common in BAV patients with a predominant AI pathophysiology. These findings convey the safety and feasibility of treating concomitant aortopathy, including arch replacement as needed, and may help tailor the specific operation needed to the patient's pathology.

Duke Scholars

Published In

The Journal of heart valve disease

EISSN

2053-2644

ISSN

0966-8519

Publication Date

July 2011

Volume

20

Issue

4

Start / End Page

387 / 395

Related Subject Headings

  • Vascular Surgical Procedures
  • Treatment Outcome
  • Retrospective Studies
  • Respiratory System
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Heart Valve Diseases
  • Follow-Up Studies
 

Citation

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Lima, B., Williams, J. B., Bhattacharya, S. D., Shah, A. A., Andersen, N., Wang, A., … Hughes, G. C. (2011). Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease. The Journal of Heart Valve Disease, 20(4), 387–395.
Lima, Brian, Judson B. Williams, S Dave Bhattacharya, Asad A. Shah, Nicholas Andersen, Andrew Wang, J Kevin Harrison, and G Chad Hughes. “Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease.The Journal of Heart Valve Disease 20, no. 4 (July 2011): 387–95.
Lima B, Williams JB, Bhattacharya SD, Shah AA, Andersen N, Wang A, et al. Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease. The Journal of heart valve disease. 2011 Jul;20(4):387–95.
Lima, Brian, et al. “Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease.The Journal of Heart Valve Disease, vol. 20, no. 4, July 2011, pp. 387–95.
Lima B, Williams JB, Bhattacharya SD, Shah AA, Andersen N, Wang A, Harrison JK, Hughes GC. Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease. The Journal of heart valve disease. 2011 Jul;20(4):387–395.

Published In

The Journal of heart valve disease

EISSN

2053-2644

ISSN

0966-8519

Publication Date

July 2011

Volume

20

Issue

4

Start / End Page

387 / 395

Related Subject Headings

  • Vascular Surgical Procedures
  • Treatment Outcome
  • Retrospective Studies
  • Respiratory System
  • Middle Aged
  • Male
  • Magnetic Resonance Angiography
  • Humans
  • Heart Valve Diseases
  • Follow-Up Studies