Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Duke University 1995
• 

  Duke Appointment History

  • Associate Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2011 - 2015
  • Assistant Professor of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2005 - 2011
  • Instructor, Temporary in the Department of Surgery, Surgery, Cardiovascular and Thoracic Surgery, Surgery 2005
• Research
• 

  Selected Grants

  • Safety and Performance of Aortic Valve Repair Using the HAART Aortic Annuloplasty Devices awarded by BioStable Science & Engineering, Inc. 2020 - 2036
  • Sure-AVR awarded by LivaNova 2019 - 2028
  • GORE - TAMBE AAA 17-01 awarded by W. L. Gore & Associates, Inc. 2020 - 2026
  • CryoLife PROACT awarded by CryoLife 2020 - 2025
  • A Prospective, Multicenter, Non-Blinded, Non-Randomized Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System in Subjects with Thoracic Aortic Pathologies Requiring Treatment Proximal to the Origin of the Innominate Artery awarded by Bolton Medical, Inc. 2019 - 2025
  • Mitrofolow Aortic Pericardial Heart Valve with Phospholipid Reduction Treatment awarded by Sorin Group 2015 - 2025
  • Placement of AoRTic TraNscathetER Valves Trial II (PARTNER II) Sapien 3 Intermediate (PIIS3i) awarded by Edwards Lifesciences Corporation 2014 - 2025
  • A Prospective, Multicenter, Non-Blinded, Non-Randomized Study of the RelayPro Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers awarded by Bolton Medical, Inc. 2019 - 2025
  • Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta awarded by W. L. Gore & Associates, Inc. 2017 - 2024
  • TAVR in Low Risk Patients awarded by Medtronic, Inc. 2016 - 2023
  • Valiant EVO US Clinical Trial awarded by Medtronic, Inc. 2016 - 2021
  • Post-Approval Study of the Relay Thoracic Stent-Graft with Plus Delivery System in Patients with Thoracic Aortic Aneurysms and Penetrating Ulcers awarded by Bolton Medical, Inc. 2014 - 2021
  • Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest awarded by National Institutes of Health 2016 - 2021
  • Metabolomic and microRNA signatures in peripheral blood of patients with thoracic aortic aneurysm awarded by Thoracic Surgery Foundation for Research and Education 2015 - 2017
  • Evaluation of the Thoraflex Hybrid Device for Use in Repair or Replacement of the Ascending Aorta, Aortic Arch, and Descending Aorta in an Open Surgical Procedure awarded by Terumo Medical Corporation 2016 - 2017
  • CardioCel Tri-leaflet Repair Study awarded by Admedus Limited 2016
  • A Retrospective Chart Review Study to Investigate Bleeding Risk and Blood Transfusion Requirements in Patients Undergoing Complex Cardiovascular Surgery in the United States awarded by CSL Behring LLC 2014 - 2015
  • A Phase II, Randomized, Placebo-Controlled, Double-Blind (Sponsor Open) Study of GSK1278863, a HIF-Prolyl Hydroxylase Inhibitor, to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair awarded by GlaxoSmithKline 2013 - 2015
  • Transmyocardial Laser Revascularization: Mechanisms . . . awarded by National Institutes of Health 1998 - 2000
• 

  External Relationships

  • Terumo Aortic
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Weissler, E Hope, Soraya L. Voigt, Vignesh Raman, Oliver Jawitz, Julie Doberne, Jatin Anand, Ryan Plichta, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Permissive Hypertension and Collateral Revascularization May Allow Avoidance of Cerebrospinal Fluid Drainage in Thoracic Endovascular Aortic Repair.” Ann Thorac Surg 110, no. 5 (November 2020): 1469–74. https://doi.org/10.1016/j.athoracsur.2020.04.101.
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    • Hughes, G Chad, and Charles M. Wojnarski. “Perioperative Transfusion Practices and Aortic Root Replacement: The Devil Is in the Details.” Ann Thorac Surg 110, no. 4 (October 2020): 1234. https://doi.org/10.1016/j.athoracsur.2020.03.115.
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    • Hughes, G Chad. “Commentary: Lack of screening makes primary prevention most effective to reduce the mortality of aortic dissection.” J Thorac Cardiovasc Surg, September 12, 2020. https://doi.org/10.1016/j.jtcvs.2020.09.031.
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    • Marquis-Gravel, Guillaume, Amanda Stebbins, Andrzej S. Kosinski, Morgan L. Cox, J Kevin Harrison, G Chad Hughes, Vinod H. Thourani, et al. “Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.” Jama Cardiol 5, no. 9 (September 1, 2020): 1006–10. https://doi.org/10.1001/jamacardio.2020.1725.
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    • Sabe, Ashraf A., Edward Percy, Tsuyoshi Kaneko, Ryan P. Plichta, and G Chad Hughes. “When to Consider Deferral of Surgery in Acute Type A Aortic Dissection: A Review.” Ann Thorac Surg, August 31, 2020. https://doi.org/10.1016/j.athoracsur.2020.08.002.
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    • Schwartz, Fides Regina, Tina Tailor, Jeffrey G. Gaca, Todd Kiefer, Kevin Harrison, G Chad Hughes, Juan-Carlos Ramirez-Giraldo, Daniele Marin, and Lynne M. Hurwitz. “Impact of dual energy cardiac CT for metal artefact reduction post aortic valve replacement.” Eur J Radiol 129 (August 2020): 109135. https://doi.org/10.1016/j.ejrad.2020.109135.
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    • Hughes, G Chad. “INVITED COMMENTARY.” Ann Thorac Surg 110, no. 1 (July 2020): 38–39. https://doi.org/10.1016/j.athoracsur.2020.01.014.
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    • Malas, Mahmoud, Satinderjit Locham, Chad Hughes, Michael Bacharach, Derek Brinster, James McKinsey, Krishna Mannava, James Wu, Saum Rahimi, and Melham Sharafuddin. “Midterm outcomes in patients undergoing endovascular repair of thoracic aortic aneurysms and penetrating atherosclerotic ulcers using the RelayPlus stent graft.” J Vasc Surg, June 19, 2020. https://doi.org/10.1016/j.jvs.2020.05.059.
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    • Marquis-Gravel, Guillaume, Amanda Stebbins, Andrzej S. Kosinski, Morgan L. Cox, J Kevin Harrison, G Chad Hughes, Vinod H. Thourani, et al. “Geographic Access to Transcatheter Aortic Valve Replacement Centers in the United States: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.” Jama Cardiol, June 10, 2020. https://doi.org/10.1001/jamacardio.2020.1725.
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    • Jawitz, Oliver K., Vignesh Raman, Jatin Anand, Muath Bishawi, Soraya L. Voigt, Julie Doberne, Andrew M. Vekstein, E Hope Weissler, Joseph W. Turek, and G Chad Hughes. “Aortic valve repair with a newly approved geometric annuloplasty ring in patients undergoing proximal aortic repair: early results from a single-centre experience.” Eur J Cardiothorac Surg 57, no. 6 (June 1, 2020): 1137–44. https://doi.org/10.1093/ejcts/ezaa009.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Adam Z. Banks, Lynne H. Koweek, Ryan Plichta, Adam Williams, et al. “Transcatheter aortic valve replacement for patients with severe bicuspid aortic stenosis.” Am Heart J 224 (June 2020): 105–12. https://doi.org/10.1016/j.ahj.2020.02.003.
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    • Bavaria, Joseph E., William T. Brinkman, G Chad Hughes, Aamir S. Shah, Kristofer M. Charlton-Ouw, Ali Azizzadeh, and Rodney A. White. “Five-year outcomes of endovascular repair of complicated acute type B aortic dissections.” J Thorac Cardiovasc Surg, May 13, 2020. https://doi.org/10.1016/j.jtcvs.2020.03.162.
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    • Hughes, G Chad. “Commentary: Left subclavian artery revascularization during zone 2 thoracic endovascular aortic repair: Bypass versus transposition? Just do it!.” J Thorac Cardiovasc Surg 159, no. 4 (April 2020): 1228–30. https://doi.org/10.1016/j.jtcvs.2019.05.050.
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    • Wang, Alice, Daniel Montgomery, Derek R. Brinster, Dan Gilon, Gilbert R. Upchurch, Thomas G. Gleason, Anthony Estrera, Eric M. Isselbacher, Kim A. Eagle, and G Chad Hughes. “Predicting In-Hospital Survival in Acute Type A Aortic Dissection Medically Treated.” J Am Coll Cardiol 75, no. 11 (March 24, 2020): 1360–61. https://doi.org/10.1016/j.jacc.2020.01.015.
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    • Chung, Matthew J., Asvin M. Ganapathi, Amit N. Vora, Jacob N. Schroder, Todd L. Kiefer, and G Chad Hughes. “Valve-in-Ring Transcatheter Aortic Valve Replacement After Left Ventricular Assist Device Therapy.” Ann Thorac Surg 109, no. 3 (March 2020): e163–65. https://doi.org/10.1016/j.athoracsur.2019.06.094.
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    • Lombardi, Joseph V., G Chad Hughes, Jehangir J. Appoo, Joseph E. Bavaria, Adam W. Beck, Richard P. Cambria, Kristofer Charlton-Ouw, et al. “Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) Reporting Standards for Type B Aortic Dissections.” Ann Thorac Surg 109, no. 3 (March 2020): 959–81. https://doi.org/10.1016/j.athoracsur.2019.10.005.
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    • Lombardi, Joseph V., G Chad Hughes, Jehangir J. Appoo, Joseph E. Bavaria, Adam W. Beck, Richard P. Cambria, Kristofer Charlton-Ouw, et al. “Society for Vascular Surgery (SVS) and Society of Thoracic Surgeons (STS) reporting standards for type B aortic dissections.” Journal of Vascular Surgery 71, no. 3 (March 2020): 723–47. https://doi.org/10.1016/j.jvs.2019.11.013.
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    • Wolsky, Ryan M., J Scott Rankin, James M. Meza, G Chad Hughes, and Joseph W. Turek. “Geometric ring annuloplasty for bicuspid aortic valve repair in a child.” J Thorac Cardiovasc Surg 159, no. 2 (February 2020): e135–37. https://doi.org/10.1016/j.jtcvs.2019.06.047.
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    • Hughes, G Chad. “Invited Commentary.” Ann Thorac Surg 109, no. 1 (January 2020): 33–35. https://doi.org/10.1016/j.athoracsur.2019.08.051.
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    • Wojnarski, Charles M., and G Chad Hughes. “Commentary: Go "all in" the way they do in Texas-Or wait to see how the hand plays out? Extent of distal repair for acute type I dissection.” J Thorac Cardiovasc Surg 158, no. 5 (November 2019): 1283–84. https://doi.org/10.1016/j.jtcvs.2019.01.051.
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    • Rymer, Jennifer A., Qun Xiang, Alice Wang, David J. Cohen, Nimesh D. Desai, Ajay J. Kirtane, G Chad Hughes, J Kevin Harrison, Andrzej S. Kosinski, and Sreekanth Vemulapalli. “Factors Associated With and Outcomes of Aborted Procedures During Elective Transcatheter Aortic Valve Replacement.” Jacc Cardiovasc Interv 12, no. 18 (September 23, 2019): 1768–77. https://doi.org/10.1016/j.jcin.2019.05.017.
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    • Wang, Alice, Zhuokai Li, Jennifer A. Rymer, Andrzej S. Kosinski, Babatunde Yerokun, Morgan L. Cox, Brian C. Gulack, et al. “Relation of Postdischarge Care Fragmentation and Outcomes in Transcatheter Aortic Valve Implantation from the STS/ACC TVT Registry.” Am J Cardiol 124, no. 6 (September 15, 2019): 912–19. https://doi.org/10.1016/j.amjcard.2019.06.005.
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    • Pineda, Andrés M., Jennifer Rymer, Alice Wang, Lynne H. Koweek, Adam Williams, Todd Kiefer, Andrew Wang, Jeffrey Gaca, G Chad Hughes, and J Kevin Harrison. “Trends and Outcomes of Alternative-Access Transcatheter Aortic Valve Replacement.” J Invasive Cardiol 31, no. 7 (July 2019): E184–91.
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    • Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/aln.0000000000002668.
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    • Stavridis, George T., Richard S. Downey, Marc W. Gerdisch, G Chad Hughes, Marek J. Jasinski, J Scott Rankin, Domenico Mazzitelli, et al. “Aortic valve repair for tri-leaflet aortic insufficiency associated with asymmetric aortic root aneurysms.” Ann Cardiothorac Surg 8, no. 3 (May 2019): 426–29. https://doi.org/10.21037/acs.2019.04.10.
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    • Wallen, Tyler, Andreas Habertheuer, Joseph E. Bavaria, G Chad Hughes, Vinay Badhwar, Jeffrey P. Jacobs, Babatunde Yerokun, et al. “Elective Aortic Root Replacement in North America: Analysis of STS Adult Cardiac Surgery Database.” Ann Thorac Surg 107, no. 5 (May 2019): 1307–12. https://doi.org/10.1016/j.athoracsur.2018.12.039.
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    • Yerokun, Babatunde A., Jatin Anand, Richard L. McCann, and G Chad Hughes. “Back stabber: ladder fall causing traumatic aortic transection.” Asian Cardiovasc Thorac Ann 27, no. 4 (May 2019): 302–3. https://doi.org/10.1177/0218492319834449.
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    • Plichta, Ryan P., Donald D. Glower, and G Chad Hughes. “Valvular Disease in Marfan Syndrome: Surgical Considerations and Management.” Curr Cardiol Rep 21, no. 4 (March 4, 2019): 23. https://doi.org/10.1007/s11886-019-1110-3.
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    • Voigt, Soraya L., Muath Bishawi, David Ranney, Babatunde Yerokun, Richard L. McCann, and G Chad Hughes. “Outcomes of carotid-subclavian bypass performed in the setting of thoracic endovascular aortic repair.” J Vasc Surg 69, no. 3 (March 2019): 701–9. https://doi.org/10.1016/j.jvs.2018.07.022.
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    • Wagner, Matthew A., Hanghang Wang, Ehsan Benrashid, Jeffrey E. Keenan, Asvin M. Ganapathi, Brian R. Englum, and G Chad Hughes. “Risk Prediction Model for Major Adverse Outcome in Proximal Thoracic Aortic Surgery.” Ann Thorac Surg 107, no. 3 (March 2019): 795–801. https://doi.org/10.1016/j.athoracsur.2018.09.052.
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    • Gould, Russell A., Hamza Aziz, Courtney E. Woods, Manuel Alejandro Seman-Senderos, Elizabeth Sparks, Christoph Preuss, Florian Wünnemann, et al. “ROBO4 variants predispose individuals to bicuspid aortic valve and thoracic aortic aneurysm.” Nat Genet 51, no. 1 (January 2019): 42–50. https://doi.org/10.1038/s41588-018-0265-y.
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    • Hughes, G Chad. “Stent graft-induced new entry tear (SINE): Intentional and NOT.” J Thorac Cardiovasc Surg 157, no. 1 (January 2019): 101-106.e3. https://doi.org/10.1016/j.jtcvs.2018.10.060.
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    • Trimarchi, Santi, Hector W. L. de Beaufort, Jip L. Tolenaar, Joseph E. Bavaria, Nimesh D. Desai, Marco Di Eusanio, Roberto Di Bartolomeo, et al. “Acute aortic dissections with entry tear in the arch: A report from the International Registry of Acute Aortic Dissection.” J Thorac Cardiovasc Surg 157, no. 1 (January 2019): 66–73. https://doi.org/10.1016/j.jtcvs.2018.07.101.
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    • Gleason, Thomas G., Michael J. Reardon, Jeffrey J. Popma, G Michael Deeb, Steven J. Yakubov, Joon S. Lee, Neal S. Kleiman, et al. “5-Year Outcomes of Self-Expanding Transcatheter Versus Surgical Aortic Valve Replacement in High-Risk Patients.” J Am Coll Cardiol 72, no. 22 (December 4, 2018): 2687–96. https://doi.org/10.1016/j.jacc.2018.08.2146.
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    • Ranney, David N., Babatunde A. Yerokun, Ehsan Benrashid, Muath Bishawi, Adam Williams, Richard L. McCann, and G Chad Hughes. “Outcomes of Planned Two-Stage Hybrid Aortic Repair With Dacron-Replaced Proximal Landing Zone.” Ann Thorac Surg 106, no. 4 (October 2018): 1136–42. https://doi.org/10.1016/j.athoracsur.2018.04.044.
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    • Vora, Amit N., Dadi Dai, Roland Matsuoka, J Kevin Harrison, G Chad Hughes, Matthew W. Sherwood, Jonathan P. Piccini, et al. “Incidence, Management, and Associated Clinical Outcomes of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: An Analysis From the STS/ACC TVT Registry.” Jacc Cardiovasc Interv 11, no. 17 (September 10, 2018): 1746–56. https://doi.org/10.1016/j.jcin.2018.05.042.
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    • Puskas, John D., Marc Gerdisch, Dennis Nichols, Lilibeth Fermin, Birger Rhenman, Divya Kapoor, Jack Copeland, et al. “Anticoagulation and Antiplatelet Strategies After On-X Mechanical Aortic Valve Replacement.” J Am Coll Cardiol 71, no. 24 (June 19, 2018): 2717–26. https://doi.org/10.1016/j.jacc.2018.03.535.
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    • Kochar, Ajar, Zhuokai Li, J Kevin Harrison, G Chad Hughes, Vinod H. Thourani, Michael J. Mack, Roland A. Matsouaka, et al. “Stroke and Cardiovascular Outcomes in Patients With Carotid Disease Undergoing Transcatheter Aortic Valve Replacement.” Circ Cardiovasc Interv 11, no. 6 (June 2018): e006322. https://doi.org/10.1161/CIRCINTERVENTIONS.117.006322.
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    • Hughes, G Chad. “Classic hybrid arch debranching (type I hybrid arch repair) without circulatory arrest.” Ann Cardiothorac Surg 7, no. 3 (May 2018): 443–50. https://doi.org/10.21037/acs.2018.05.06.
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    • Klinger, Rebecca Y., Olga G. James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, et al. “18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.” Anesthesiology 128, no. 4 (April 2018): 728–44. https://doi.org/10.1097/ALN.0000000000002103.
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    • Gleason, Thomas G., John T. Schindler, Robert C. Hagberg, G Michael Deeb, David H. Adams, John V. Conte, George L. Zorn, et al. “Subclavian/Axillary Access for Self-Expanding Transcatheter Aortic Valve Replacement Renders Equivalent Outcomes as Transfemoral.” Ann Thorac Surg 105, no. 2 (February 2018): 477–83. https://doi.org/10.1016/j.athoracsur.2017.07.017.
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    • Keeling, W Brent, David H. Tian, Brad G. Leshnower, Satoshi Numata, G Chad Hughes, George Matalanis, Yutaka Okita, et al. “Safety of Moderate Hypothermia With Antegrade Cerebral Perfusion in Total Aortic Arch Replacement.” Ann Thorac Surg 105, no. 1 (January 2018): 54–61. https://doi.org/10.1016/j.athoracsur.2017.06.072.
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    • Lee, Teng C., Zachary Kon, Faisal H. Cheema, Maria V. Grau-Sepulveda, Brian Englum, Sunghee Kim, Paramita S. Chaudhuri, et al. “Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database.” J Card Surg 33, no. 1 (January 2018): 7–18. https://doi.org/10.1111/jocs.13511.
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    • Plichta, Ryan P., and G Chad Hughes. “Thoracic endovascular aortic repair for the ascending aorta: experience and pitfalls.” J Vis Surg 4 (2018): 92. https://doi.org/10.21037/jovs.2018.03.01.
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    • Wang, Alice, Asvin M. Ganapathi, Andrew Wang, and G Chad Hughes. “The Modified Ross Procedure with Prosthetic Graft Wrap Does Not Prevent Autograft Failure.” J Heart Valve Dis 26, no. 6 (November 2017): 735–37.
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    • Fanaroff, Alexander C., Pratik Manandhar, David R. Holmes, David J. Cohen, J Kevin Harrison, G Chad Hughes, Vinod H. Thourani, et al. “Peripheral Artery Disease and Transcatheter Aortic Valve Replacement Outcomes: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Therapy Registry.” Circ Cardiovasc Interv 10, no. 10 (October 2017). https://doi.org/10.1161/CIRCINTERVENTIONS.117.005456.
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    • Karhausen, Jörn A., Alan M. Smeltz, Igor Akushevich, Mary Cooter, Mihai V. Podgoreanu, Mark Stafford-Smith, Susan M. Martinelli, Manuel L. Fontes, and Miklos D. Kertai. “Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery.” Anesth Analg 125, no. 4 (October 2017): 1129–39. https://doi.org/10.1213/ANE.0000000000002187.
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    • Englum, Brian R., Xia He, Brian C. Gulack, Asvin M. Ganapathi, Joseph P. Mathew, J Matthew Brennan, T Brett Reece, et al. “Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database.” Eur J Cardiothorac Surg 52, no. 3 (September 1, 2017): 492–98. https://doi.org/10.1093/ejcts/ezx133.
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    • Iribarne, Alexander, Jeffrey Keenan, Ehsan Benrashid, Hanghang Wang, James M. Meza, Asvin Ganapathi, Jeffrey G. Gaca, Han W. Kim, Lynne M. Hurwitz, and G Chad Hughes. “Imaging Surveillance After Proximal Aortic Operations: Is it Necessary?” Ann Thorac Surg 103, no. 3 (March 2017): 734–41. https://doi.org/10.1016/j.athoracsur.2016.06.085.
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    • Popma, Jeffrey J., Michael J. Reardon, Kamal Khabbaz, J Kevin Harrison, G Chad Hughes, Susheel Kodali, Isaac George, et al. “Early Clinical Outcomes After Transcatheter Aortic Valve Replacement Using a Novel Self-Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Who Are Suboptimal for Surgery: Results of the Evolut R U.S. Study.” Jacc Cardiovasc Interv 10, no. 3 (February 13, 2017): 268–75. https://doi.org/10.1016/j.jcin.2016.08.050.
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    • Harrison, J Kevin, G Chad Hughes, Michael J. Reardon, Robert Stoler, Paul Grayburn, Robert Hebeler, David Liu, Yanping Chang, Jeffrey J. Popma, and Jeffrey J. CoreValve US Clinical Investigators. “Balloon Post-Dilation Following Implantation of a Self-Expanding Transcatheter Aortic Valve Bioprosthesis.” Jacc Cardiovasc Interv 10, no. 2 (January 23, 2017): 168–75. https://doi.org/10.1016/j.jcin.2016.11.002.
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    • Kertai, Miklos D., Sreekanth Cheruku, Wenjing Qi, Yi-Ju Li, G Chad Hughes, Joseph P. Mathew, and Jörn A. Karhausen. “Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 153, no. 1 (January 2017): 68-76.e2. https://doi.org/10.1016/j.jtcvs.2016.05.063.
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    • Kiefer, Todd L., John Vavalle, Lynne M. Hurwitz, G Chad Hughes, and J Kevin Harrison. “Resolution of severe hemolysis and paravalvular aortic regurgitation employing an Amplatzer Vascular Plug 4: the importance of detailed pre-procedural planning using CT angiography.” Cardiovasc Interv Ther 32, no. 1 (January 2017): 48–52. https://doi.org/10.1007/s12928-015-0363-z.
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    • Keenan, Jeffrey E., Ehsan Benrashid, Emily Kale, Alina Nicoara, Aatif M. Husain, and G Chad Hughes. “Neurophysiological Intraoperative Monitoring During Aortic Arch Surgery.” Semin Cardiothorac Vasc Anesth 20, no. 4 (December 2016): 273–82. https://doi.org/10.1177/1089253216672441.
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    • Keenan, Jeffrey E., Hanghang Wang, Brian C. Gulack, Asvin M. Ganapathi, Nicholas D. Andersen, Brian R. Englum, Yamini Krishnamurthy, Jerrold H. Levy, Ian J. Welsby, and G Chad Hughes. “Does moderate hypothermia really carry less bleeding risk than deep hypothermia for circulatory arrest? A propensity-matched comparison in hemiarch replacement.” J Thorac Cardiovasc Surg 152, no. 6 (December 2016): 1559-1569.e2. https://doi.org/10.1016/j.jtcvs.2016.08.014.
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    • Nauta, Foeke J. H., Jip L. Tolenaar, Himanshu J. Patel, Jehangir J. Appoo, Thomas T. Tsai, Nimesh D. Desai, Daniel G. Montgomery, et al. “Impact of Retrograde Arch Extension in Acute Type B Aortic Dissection on Management and Outcomes.” Ann Thorac Surg 102, no. 6 (December 2016): 2036–43. https://doi.org/10.1016/j.athoracsur.2016.05.013.
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    • Benrashid, Ehsan, Hanghang Wang, Nicholas D. Andersen, Jeffrey E. Keenan, Richard L. McCann, and G Chad Hughes. “Complementary roles of open and hybrid approaches to thoracoabdominal aortic aneurysm repair.” J Vasc Surg 64, no. 5 (November 2016): 1228–38. https://doi.org/10.1016/j.jvs.2016.04.022.
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    • Gleason, Thomas, Jeffrey Popma, Michael Reardon, John Schindler, Robert Hagberg, G Michael Deeb, David Adams, John Conte, Trip Zorn, and G Chad Hughes. “TCT-372 Subclavian Access for Self-Expanding Transcatheter Aortic Valve Replacement Renders Equivalent Outcomes as Transfemoral.” J Am Coll Cardiol 68, no. 18S (November 1, 2016): B152. https://doi.org/10.1016/j.jacc.2016.09.505.
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    • Popma, Jeffrey, George Dibu, G Chad Hughes, Susheel Kodali, Isaac George, Jae Oh, James Slater, and Mathew Williams. “TCT-37 Transcatheter Aortic Valve Replacement with a Repositionable Self-expanding Bioprosthesis in Patients With Severe Aortic Stenosis at High Risk for Surgery: One-Year Results from the Evolut R US Pivotal Study.” J Am Coll Cardiol 68, no. 18S (November 1, 2016): B16. https://doi.org/10.1016/j.jacc.2016.09.174.
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    • Reardon, Michael J., Neal S. Kleiman, David H. Adams, Steven J. Yakubov, Joseph S. Coselli, G Michael Deeb, Daniel O’Hair, et al. “Outcomes in the Randomized CoreValve US Pivotal High Risk Trial in Patients With a Society of Thoracic Surgeons Risk Score of 7% or Less.” Jama Cardiol 1, no. 8 (November 1, 2016): 945–49. https://doi.org/10.1001/jamacardio.2016.2257.
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    • Sherwood, Matthew, Qun Xiang, Roland Matsouaka, G Chad Hughes, Sreekanth Vemulapalli, Amit Vora, Eric Peterson, and Sunil Rao. “TCT-78 Incidence and Outcomes of Vascular Complications and Bleeding Events in Patients undergoing TAVR in contemporary U.S. practice: Insights from the STS/ACC TVT Registry®.” J Am Coll Cardiol 68, no. 18S (November 1, 2016): B32. https://doi.org/10.1016/j.jacc.2016.09.226.
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    • Andersen, Nicholas D., and G Chad Hughes. “Concomitant replacement of the ascending aorta is free-for some.” J Thorac Cardiovasc Surg 152, no. 3 (September 2016): 799–800. https://doi.org/10.1016/j.jtcvs.2016.06.022.
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    • Gleason, Thomas G., John T. Schindler, David H. Adams, Michael J. Reardon, Neal S. Kleiman, Louis R. Caplan, John V. Conte, et al. “The risk and extent of neurologic events are equivalent for high-risk patients treated with transcatheter or surgical aortic valve replacement.” J Thorac Cardiovasc Surg 152, no. 1 (July 2016): 85–96. https://doi.org/10.1016/j.jtcvs.2016.02.073.
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    • Deeb, G Michael, Michael J. Reardon, Stan Chetcuti, Himanshu J. Patel, P Michael Grossman, Steven J. Yakubov, Neal S. Kleiman, et al. “3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement.” J Am Coll Cardiol 67, no. 22 (June 7, 2016): 2565–74. https://doi.org/10.1016/j.jacc.2016.03.506.
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    • Hughes, G Chad. “Invited Commentary.” Ann Thorac Surg 101, no. 6 (June 2016): 2235–36. https://doi.org/10.1016/j.athoracsur.2016.01.051.
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    • Andersen, Nicholas D., Ehsan Benrashid, Adia K. Ross, Lisa C. Pickett, Peter K. Smith, Mani A. Daneshmand, Jacob N. Schroder, Jeffrey G. Gaca, and G Chad Hughes. “The utility of the aortic dissection team: outcomes and insights after a decade of experience.” Ann Cardiothorac Surg 5, no. 3 (May 2016): 194–201. https://doi.org/10.21037/acs.2016.05.12.
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    • Hanna, Jennifer M., Jeffrey E. Keenan, Hanghang Wang, Nicholas D. Andersen, Jeffrey G. Gaca, Frederick W. Lombard, Ian J. Welsby, and G Chad Hughes. “Use of human fibrinogen concentrate during proximal aortic reconstruction with deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 151, no. 2 (February 2016): 376–82. https://doi.org/10.1016/j.jtcvs.2015.08.079.
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    • Schechter, Matthew A., Asad A. Shah, Brian R. Englum, Judson B. Williams, Asvin M. Ganapathi, John D. Davies, Ian J. Welsby, and G Chad Hughes. “Prolonged postoperative respiratory support after proximal thoracic aortic surgery: Is deep hypothermic circulatory arrest a risk factor?” J Crit Care 31, no. 1 (February 2016): 125–29. https://doi.org/10.1016/j.jcrc.2015.10.021.
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    • Conte, John V., Thomas G. Gleason, Jon R. Resar, David H. Adams, G Michael Deeb, Jeffrey J. Popma, G Chad Hughes, George L. Zorn, and Michael J. Reardon. “Transcatheter or Surgical Aortic Valve Replacement in Patients With Prior Coronary Artery Bypass Grafting.” Ann Thorac Surg 101, no. 1 (January 2016): 72–79. https://doi.org/10.1016/j.athoracsur.2015.06.067.
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    • Englum, Brian R., Asvin M. Ganapathi, Matthew A. Schechter, J Kevin Harrison, Donald D. Glower, and G Chad Hughes. “Changes in Risk Profile and Outcomes of Patients Undergoing Surgical Aortic Valve Replacement From the Pre- to Post-Transcatheter Aortic Valve Replacement Eras.” Ann Thorac Surg 101, no. 1 (January 2016): 110–17. https://doi.org/10.1016/j.athoracsur.2015.06.083.
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    • Illig, Karl A., Takao Ohki, G Chad Hughes, Masaaki Kato, Hideyuki Shimizu, Himanshu J. Patel, Ali Shahriari, Shraddha Mehta, and Shraddha Zenith TX2 Low Profile study investigators. “One-year outcomes from the international multicenter study of the Zenith Alpha Thoracic Endovascular Graft for thoracic endovascular repair.” J Vasc Surg 62, no. 6 (December 2015): 1485-94.e2. https://doi.org/10.1016/j.jvs.2015.05.007.
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    • Davis, Robert Patrick, Nicholas D. Andersen, Asvin M. Ganapathi, Louis R. DiBernardo, and G Chad Hughes. “Repair of Bicuspid Aortic Valve Syndrome with Anomalous Right Coronary Artery in Osteogenesis Imperfecta.” J Heart Valve Dis 24, no. 6 (November 2015): 666–68.
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    • Klinger, Rebecca Y., Christopher A. Thunberg, William D. White, Manuel Fontes, Nathan H. Waldron, Jonathan P. Piccini, G Chad Hughes, et al. “Intraoperative Magnesium Administration Does Not Reduce Postoperative Atrial Fibrillation After Cardiac Surgery.” Anesth Analg 121, no. 4 (October 2015): 861–67. https://doi.org/10.1213/ANE.0000000000000873.
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    • Yakubov, Steven J., David H. Adams, Daniel R. Watson, Michael J. Reardon, Neal S. Kleiman, David Heimansohn, James Hermiller, et al. “2-Year Outcomes After Iliofemoral Self-Expanding Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis Deemed Extreme Risk for Surgery.” J Am Coll Cardiol 66, no. 12 (September 22, 2015): 1327–34. https://doi.org/10.1016/j.jacc.2015.07.042.
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    • Bavaria, Joseph E., William T. Brinkman, G Chad Hughes, Ali Khoynezhad, Wilson Y. Szeto, Ali Azizzadeh, W Anthony Lee, and Rodney A. White. “Outcomes of Thoracic Endovascular Aortic Repair in Acute Type B Aortic Dissection: Results From the Valiant United States Investigational Device Exemption Study.” Ann Thorac Surg 100, no. 3 (September 2015): 802–8. https://doi.org/10.1016/j.athoracsur.2015.03.108.
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    • Shah, Asad A., Simon G. Gregory, Deidre Krupp, Sheng Feng, Allison Dorogi, Carol Haynes, Elizabeth Grass, et al. “Epigenetic profiling identifies novel genes for ascending aortic aneurysm formation with bicuspid aortic valves.” Heart Surg Forum 18, no. 4 (August 30, 2015): E134–39. https://doi.org/10.1532/hsf.1247.
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    • Ganapathi, Asvin M., Brian R. Englum, Jeffrey E. Keenan, Matthew A. Schechter, Hanghang Wang, Peter K. Smith, Donald D. Glower, and G Chad Hughes. “Long-Term Survival After Bovine Pericardial Versus Porcine Stented Bioprosthetic Aortic Valve Replacement: Does Valve Choice Matter?” Ann Thorac Surg 100, no. 2 (August 2015): 550–59. https://doi.org/10.1016/j.athoracsur.2015.02.067.
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    • Reardon, Michael J., David H. Adams, Neal S. Kleiman, Steven J. Yakubov, Joseph S. Coselli, G Michael Deeb, Thomas G. Gleason, et al. “2-Year Outcomes in Patients Undergoing Surgical or Self-Expanding Transcatheter Aortic Valve Replacement.” J Am Coll Cardiol 66, no. 2 (July 14, 2015): 113–21. https://doi.org/10.1016/j.jacc.2015.05.017.
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    • Keenan, Jeffrey E., John P. Vavalle, Asvin M. Ganapathi, Hanghang Wang, J Kevin Harrison, Andrew Wang, and G Chad Hughes. “Factor VIIa for Annulus Rupture After Transcatheter Aortic Valve Replacement.” Ann Thorac Surg 100, no. 1 (July 2015): 313–15. https://doi.org/10.1016/j.athoracsur.2014.09.063.
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    • Klein, Michael R., Frida Sundh, Jacob Simlund, J Kevin Harrison, Kevin P. Jackson, G Chad Hughes, Galen S. Wagner, et al. “Immediate mechanical effects of acute left bundle branch block by speckle tracked strain.” J Electrocardiol 48, no. 4 (July 2015): 643–51. https://doi.org/10.1016/j.jelectrocard.2015.05.005.
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    • Wang, Hanghang, Jennifer M. Hanna, Asvin Ganapathi, Jeffrey E. Keenan, Lynne M. Hurwitz, John P. Vavalle, Todd L. Kiefer, Andrew Wang, J Kevin Harrison, and G Chad Hughes. “Comparison of aortic annulus size by transesophageal echocardiography and computed tomography angiography with direct surgical measurement.” Am J Cardiol 115, no. 11 (June 1, 2015): 1568–73. https://doi.org/10.1016/j.amjcard.2015.02.060.
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    • Di Eusanio, Marco, Santi Trimarchi, Mark D. Peterson, Truls Myrmel, G Chad Hughes, Amit Korach, Thoralf M. Sundt, et al. “Root replacement surgery versus more conservative management during type A acute aortic dissection repair.” Ann Thorac Surg 98, no. 6 (December 2014): 2078–84. https://doi.org/10.1016/j.athoracsur.2014.06.070.
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    • Ganapathi, Asvin M., Jennifer M. Hanna, Matthew A. Schechter, Brian R. Englum, Anthony W. Castleberry, Jeffrey G. Gaca, and G Chad Hughes. “Antegrade versus retrograde cerebral perfusion for hemiarch replacement with deep hypothermic circulatory arrest: does it matter? A propensity-matched analysis.” J Thorac Cardiovasc Surg 148, no. 6 (December 2014): 2896–2902. https://doi.org/10.1016/j.jtcvs.2014.04.014.
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    • Hughes, G Chad, Asvin M. Ganapathi, Jeffrey E. Keenan, Brian R. Englum, Jennifer M. Hanna, Matthew A. Schechter, Hanghang Wang, and Richard L. McCann. “Thoracic endovascular aortic repair for chronic DeBakey IIIb aortic dissection.” Ann Thorac Surg 98, no. 6 (December 2014): 2092–97. https://doi.org/10.1016/j.athoracsur.2014.06.066.
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    • Dean, Joshua H., Elise M. Woznicki, Patrick O’Gara, Daniel G. Montgomery, Santi Trimarchi, Truls Myrmel, Reed E. Pyeritz, et al. “Cocaine-related aortic dissection: lessons from the International Registry of Acute Aortic Dissection.” Am J Med 127, no. 9 (September 2014): 878–85. https://doi.org/10.1016/j.amjmed.2014.05.005.
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    • Vavalle, John P., Harry R. Phillips, Sara A. Holleran, Andrew Wang, Christopher M. O’Connor, Peter K. Smith, G Chad Hughes, J Kevin Harrison, and Manesh R. Patel. “Analysis of geographic variations in the diagnosis and treatment of patients with aortic stenosis in North Carolina.” Am J Cardiol 113, no. 11 (June 1, 2014): 1874–78. https://doi.org/10.1016/j.amjcard.2014.03.021.
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    • Popma, Jeffrey J., David H. Adams, Michael J. Reardon, Steven J. Yakubov, Neal S. Kleiman, David Heimansohn, James Hermiller, et al. “Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery.” J Am Coll Cardiol 63, no. 19 (May 20, 2014): 1972–81. https://doi.org/10.1016/j.jacc.2014.02.556.
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    • Adams, David H., Jeffrey J. Popma, Michael J. Reardon, Steven J. Yakubov, Joseph S. Coselli, G Michael Deeb, Thomas G. Gleason, et al. “Transcatheter aortic-valve replacement with a self-expanding prosthesis.” N Engl J Med 370, no. 19 (May 8, 2014): 1790–98. https://doi.org/10.1056/NEJMoa1400590.
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    • Andersen, Nicholas D., Asvin M. Ganapathi, Jennifer M. Hanna, Judson B. Williams, Jeffrey G. Gaca, and G Chad Hughes. “Outcomes of acute type a dissection repair before and after implementation of a multidisciplinary thoracic aortic surgery program.” J Am Coll Cardiol 63, no. 17 (May 6, 2014): 1796–1803. https://doi.org/10.1016/j.jacc.2013.10.085.
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    • Andersen, Nicholas D., J Matthew Brennan, Yue Zhao, Judson B. Williams, Matthew L. Williams, Peter K. Smith, John E. Scarborough, and G Chad Hughes. “Insurance status is associated with acuity of presentation and outcomes for thoracic aortic operations.” Circ Cardiovasc Qual Outcomes 7, no. 3 (May 2014): 398–406. https://doi.org/10.1161/CIRCOUTCOMES.113.000593.
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    • Andersen, Nicholas D., Jeffrey E. Keenan, Asvin M. Ganapathi, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting.” Ann Cardiothorac Surg 3, no. 3 (May 2014): 264–74. https://doi.org/10.3978/j.issn.2225-319X.2014.05.07.
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    • Vavalle, John P., Todd L. Kiefer, Carmelo A. Milano, J Kevin Harrison, and G Chad Hughes. “Transcatheter aortic valve replacement performed via left ventricular assist device inflow cannula.” Circ Heart Fail 7, no. 3 (May 2014): 544–46. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001232.
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    • Yan, Tristan D., David H. Tian, Scott A. LeMaire, G Chad Hughes, Edward P. Chen, Martin Misfeld, Randall B. Griepp, et al. “Standardizing clinical end points in aortic arch surgery: a consensus statement from the International Aortic Arch Surgery Study Group.” Circulation 129, no. 15 (April 15, 2014): 1610–16. https://doi.org/10.1161/CIRCULATIONAHA.113.006421.
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    • Puskas, John, Marc Gerdisch, Dennis Nichols, Reed Quinn, Charles Anderson, Birger Rhenman, Lilibeth Fermin, et al. “Reduced anticoagulation after mechanical aortic valve replacement: interim results from the prospective randomized on-X valve anticoagulation clinical trial randomized Food and Drug Administration investigational device exemption trial.” J Thorac Cardiovasc Surg 147, no. 4 (April 2014): 1202–10. https://doi.org/10.1016/j.jtcvs.2014.01.004.
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    • Kiefer, Todd L., G Chad Hughes, Jeffrey Chad Johnson, and J Kevin Harrison. “Aortic subannular left ventricular aneurysm: a rare and surgically correctable cause of angina.” Ann Thorac Surg 97, no. 1 (January 2014): 313–15. https://doi.org/10.1016/j.athoracsur.2013.04.130.
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    • Yan, Tristan D., David H. Tian, Scott A. LeMaire, Martin Misfeld, John A. Elefteriades, Edward P. Chen, G Chad Hughes, et al. “The ARCH Projects: design and rationale (IAASSG 001).” Eur J Cardiothorac Surg 45, no. 1 (January 2014): 10–16. https://doi.org/10.1093/ejcts/ezt520.
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    • Chad Hughes, G., N. D. Andersen, and R. L. McCann. “Endovascular Repair of Chronic Type B Aortic Dissection With Aneurysmal Degeneration.” Operative Techniques in Thoracic and Cardiovascular Surgery 18, no. 2 (December 16, 2013): 101–16. https://doi.org/10.1053/j.optechstcvs.2013.04.003.
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    • Gaca, Jeffrey G., Robert M. Clare, J Scott Rankin, Mani A. Daneshmand, Carmelo A. Milano, G Chad Hughes, Walter G. Wolfe, Donald D. Glower, and Peter K. Smith. “Risk-adjusted survival after tissue versus mechanical aortic valve replacement: a 23-year assessment.” J Heart Valve Dis 22, no. 6 (November 2013): 810–16.
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    • Ong, Daniel S., Robert A. Aertker, Alexandra N. Clark, Todd Kiefer, G Chad Hughes, J Kevin Harrison, and Thomas M. Bashore. “Radiation-associated valvular heart disease.” J Heart Valve Dis 22, no. 6 (November 2013): 883–92.
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    • Halim, Sharif A., Todd L. Kiefer, G Chad Hughes, Lynne M. Hurwitz, and J Kevin Harrison. “Transcatheter aortic valve replacement: an update.” Curr Cardiol Rep 15, no. 6 (June 2013): 367. https://doi.org/10.1007/s11886-013-0367-1.
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    • Shah, A. A., R. L. Mccann, and G. C. Hughes. “Conformable Gore® TAG® Thoracic Endoprosthesis for the treatment of thoracic aortic aneurysms.” Interventional Cardiology (London) 5, no. 3 (June 1, 2013): 267–74. https://doi.org/10.2217/ica.13.14.
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    • Ikonomidis, John S., Charlotte R. Ivey, Jason B. Wheeler, Adam W. Akerman, Allison Rice, Risha K. Patel, Robert E. Stroud, et al. “Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease.” J Thorac Cardiovasc Surg 145, no. 5 (May 2013): 1326–33. https://doi.org/10.1016/j.jtcvs.2012.12.027.
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    • Englum, Brian R., Nicholas D. Andersen, Aatif M. Husain, Joseph P. Mathew, and G Chad Hughes. “Degree of hypothermia in aortic arch surgery - optimal temperature for cerebral and spinal protection: deep hypothermia remains the gold standard in the absence of randomized data.” Ann Cardiothorac Surg 2, no. 2 (March 2013): 184–93. https://doi.org/10.3978/j.issn.2225-319X.2013.03.01.
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    • Ganapathi, Asvin M., Nicholas D. Andersen, Deyanira J. Prastein, Zubair A. Hashmi, Joseph G. Rogers, Carmelo A. Milano, Richard L. McCann, and G Chad Hughes. “Endovascular stent grafting of a left ventricular assist device outflow graft pseudoaneurysm.” Circ Heart Fail 6, no. 1 (January 2013): e16–18. https://doi.org/10.1161/CIRCHEARTFAILURE.112.971861.
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    • Hughes, G Chad, Yue Zhao, J Scott Rankin, John E. Scarborough, Sean O’Brien, Joseph E. Bavaria, Walter G. Wolfe, et al. “Effects of institutional volumes on operative outcomes for aortic root replacement in North America.” J Thorac Cardiovasc Surg 145, no. 1 (January 2013): 166–70. https://doi.org/10.1016/j.jtcvs.2011.10.094.
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    • Nelson, James A., John Vavalle, Sharif Halim, G. C. Hughes, Andrew Wang, Lynne Koweek, Donald Glower, Jeff Gaca, John Alexander, and John K. Harrison. “Who is Being Referred for TAVR?: Patterns of Referral for TAVR at a Single Academic Medical Center.” Circulation 126, no. 21 (November 20, 2012).
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    • Shah, Asad A., Michael E. Barfield, Nicholas D. Andersen, Judson B. Williams, Julie A. Shah, Jennifer M. Hanna, Richard L. McCann, and G Chad Hughes. “Results of thoracic endovascular aortic repair 6 years after United States Food and Drug Administration approval.” Ann Thorac Surg 94, no. 5 (November 2012): 1394–99. https://doi.org/10.1016/j.athoracsur.2012.05.072.
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    • Steinberg, Benjamin A., J Kevin Harrison, Camille Frazier-Mills, G Chad Hughes, and Jonathan P. Piccini. “Cardiac conduction system disease after transcatheter aortic valve replacement.” Am Heart J 164, no. 5 (November 2012): 664–71. https://doi.org/10.1016/j.ahj.2012.07.028.
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    • Hughes, G Chad, Michael E. Barfield, Asad A. Shah, Judson B. Williams, Maragatha Kuchibhatla, Jennifer M. Hanna, Nicholas D. Andersen, and Richard L. McCann. “Staged total abdominal debranching and thoracic endovascular aortic repair for thoracoabdominal aneurysm.” J Vasc Surg 56, no. 3 (September 2012): 621–29. https://doi.org/10.1016/j.jvs.2011.11.149.
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    • Andersen, Nicholas D., Judson B. Williams, Emil L. Fosbol, Asad A. Shah, Syamal D. Bhattacharya, Rajendra H. Mehta, and G Chad Hughes. “Cardiac catheterization within 1 to 3 days of proximal aortic surgery is not associated with increased postoperative acute kidney injury.” J Thorac Cardiovasc Surg 143, no. 6 (June 2012): 1404–10. https://doi.org/10.1016/j.jtcvs.2012.01.069.
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    • Andersen, Nicholas D., Syamal D. Bhattacharya, Judson B. Williams, Emil L. Fosbol, Evelyn L. Lockhart, Mayur B. Patel, Jeffrey G. Gaca, Ian J. Welsby, and G Chad Hughes. “Intraoperative use of low-dose recombinant activated factor VII during thoracic aortic operations.” Ann Thorac Surg 93, no. 6 (June 2012): 1921–28. https://doi.org/10.1016/j.athoracsur.2012.02.037.
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    • Williams, Judson B., Nicholas D. Andersen, Syamal D. Bhattacharya, Elizabeth Scheer, Jonathan P. Piccini, Richard L. McCann, and G Chad Hughes. “Retrograde ascending aortic dissection as an early complication of thoracic endovascular aortic repair.” J Vasc Surg 55, no. 5 (May 2012): 1255–62. https://doi.org/10.1016/j.jvs.2011.11.063.
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    • Shah, Asad A., Damian M. Craig, Jacqueline K. Sebek, Carol Haynes, Robert C. Stevens, Michael J. Muehlbauer, Christopher B. Granger, et al. “Metabolic profiles predict adverse events after coronary artery bypass grafting.” J Thorac Cardiovasc Surg 143, no. 4 (April 2012): 873–78. https://doi.org/10.1016/j.jtcvs.2011.09.070.
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    • Andersen, Nicholas D., Judson B. Williams, J Kevin Harrison, and G Chad Hughes. “Ascending-descending aortic bypass with valve-sparing root replacement for coarctation with aortic root aneurysm.” J Thorac Cardiovasc Surg 143, no. 2 (February 2012): 514–15. https://doi.org/10.1016/j.jtcvs.2011.07.047.
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    • Hughes, G Chad. “Endovascular repair will be the best option for thoracoabdominal aortic aneurysm in 2020.” Tex Heart Inst J 39, no. 6 (2012): 834–35.
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    • Kiefer, Todd L., Andrew Wang, G Chad Hughes, and Thomas M. Bashore. “Management of patients with bicuspid aortic valve disease.” Curr Treat Options Cardiovasc Med 13, no. 6 (December 2011): 489–505. https://doi.org/10.1007/s11936-011-0152-7.
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    • Lima, Brian, Judson B. Williams, S Dave Bhattacharya, Asad A. Shah, Nicholas Andersen, Jeffrey G. Gaca, and G Chad Hughes. “Results of proximal arch replacement using deep hypothermia for circulatory arrest: is moderate hypothermia really justifiable?” Am Surg 77, no. 11 (November 2011): 1438–44.
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    • Andersen, Nicholas D., Syamal D. Bhattacharya, Judson B. Williams, Richard L. McCann, and G Chad Hughes. “Mycotic aneurysm of the thoracoabdominal aorta in a child with end-stage renal disease.” J Vasc Surg 54, no. 4 (October 2011): 1161–63. https://doi.org/10.1016/j.jvs.2011.04.051.
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    • Mehta, Rajendra H., Emily Honeycutt, Uptal D. Patel, Renato D. Lopes, Judson B. Williams, Linda K. Shaw, Sean M. O’Brien, Robert M. Califf, G Chad Hughes, and Michael H. Sketch. “Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury.” Circulation 124, no. 11 Suppl (September 13, 2011): S149–55. https://doi.org/10.1161/CIRCULATIONAHA.110.011700.
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    • Lee, Teng C., Nicholas D. Andersen, Judson B. Williams, Syamal D. Bhattacharya, Richard L. McCann, and G Chad Hughes. “Results with a selective revascularization strategy for left subclavian artery coverage during thoracic endovascular aortic repair.” Ann Thorac Surg 92, no. 1 (July 2011): 97–102. https://doi.org/10.1016/j.athoracsur.2011.03.089.
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    • Lima, Brian, Judson B. Williams, S Dave Bhattacharya, Asad A. Shah, Nicholas Andersen, Andrew Wang, J Kevin Harrison, and G Chad Hughes. “Individualized thoracic aortic replacement for the aortopathy of biscuspid aortic valve disease.” J Heart Valve Dis 20, no. 4 (July 2011): 387–95.
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    • Swaminathan, Madhav, Alina Nicoara, Barbara G. Phillips-Bute, Nicolas Aeschlimann, Carmelo A. Milano, G Burkhard Mackensen, Mihai V. Podgoreanu, et al. “Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery.” Ann Thorac Surg 91, no. 6 (June 2011): 1844–50. https://doi.org/10.1016/j.athoracsur.2011.02.008.
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    • Shah, Asad A., Syamal D. Bhattacharya, Richard L. McCann, and G Chad Hughes. “Pan-aortic hybrid treatment of mega-aorta syndrome.” J Vasc Surg 53, no. 5 (May 2011): 1398–1401. https://doi.org/10.1016/j.jvs.2010.11.115.
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    • Williams, Judson B., Barbara Phillips-Bute, Syamal D. Bhattacharya, Asad A. Shah, Nicholas D. Andersen, Burak Altintas, Brian Lima, Peter K. Smith, G Chad Hughes, and Ian J. Welsby. “Predictors of massive transfusion with thoracic aortic procedures involving deep hypothermic circulatory arrest.” J Thorac Cardiovasc Surg 141, no. 5 (May 2011): 1283–88. https://doi.org/10.1016/j.jtcvs.2010.07.098.
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    • Williams, Judson B., Richard L. McCann, and G Chad Hughes. “Total aortic replacement in Loeys-Dietz syndrome.” J Card Surg 26, no. 3 (May 2011): 304–8. https://doi.org/10.1111/j.1540-8191.2011.01224.x.
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    • Parsa, Cyrus J., Judson B. Williams, Syamal D. Bhattacharya, Walter G. Wolfe, Mani A. Daneshmand, Richard L. McCann, and G Chad Hughes. “Midterm results with thoracic endovascular aortic repair for chronic type B aortic dissection with associated aneurysm.” J Thorac Cardiovasc Surg 141, no. 2 (February 2011): 322–27. https://doi.org/10.1016/j.jtcvs.2010.10.043.
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    • Gaca, Jeffrey G., Shubin Sheng, Mani A. Daneshmand, Sean O’Brien, J Scott Rankin, J Matthew Brennan, G Chad Hughes, Donald D. Glower, James S. Gammie, and Peter K. Smith. “Outcomes for endocarditis surgery in North America: a simplified risk scoring system.” J Thorac Cardiovasc Surg 141, no. 1 (January 2011): 98-106.e1-2. https://doi.org/10.1016/j.jtcvs.2010.09.016.
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    • Hughes, G Chad. “Aggressive aortic replacement for Loeys-Dietz syndrome.” Tex Heart Inst J 38, no. 6 (2011): 663–66.
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    • Williams, Matthew L., Shubin Sheng, James S. Gammie, J Scott Rankin, Peter K. Smith, and G Chad Hughes. “Richard E. Clark Award. Aortic dissection as a complication of cardiac surgery: report from the Society of Thoracic Surgeons database.” Ann Thorac Surg 90, no. 6 (December 2010): 1812–16. https://doi.org/10.1016/j.athoracsur.2010.05.023.
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    • Hughes, G Chad, Sean M. Lee, Mani A. Daneshmand, Syamal D. Bhattacharya, Judson B. Williams, Sonny W. Tucker, and Richard L. McCann. “Endovascular repair of descending thoracic aneurysms: results with "on-label" application in the post Food and Drug Administration approval era.” Ann Thorac Surg 90, no. 1 (July 2010): 83–89. https://doi.org/10.1016/j.athoracsur.2010.03.052.
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    • Hudson, Christopher C. C., Ian J. Welsby, Barbara Phillips-Bute, Joseph P. Mathew, Andrew Lutz, G. Chad Hughes, Mark Stafford-Smith, and Mark Cardiothoracic Anesthesiology Research Endeavors (C.A.R.E.) Group. “Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients.” Can J Anaesth 57, no. 6 (June 2010): 565–72. https://doi.org/10.1007/s12630-010-9294-4.
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    • Parsa, Cyrus J., Richard L. McCann, and G Chad Hughes. “Novel approach to the treatment of distal malperfusion secondary to ascending aortic dissection.” J Card Surg 25, no. 2 (March 2010): 220–22. https://doi.org/10.1111/j.1540-8191.2009.00991.x.
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    • Williams, Matthew L., Stephanie Burns Wechsler, and G Chad Hughes. “Two-stage total aortic replacement for Loeys-Dietz syndrome.” J Card Surg 25, no. 2 (March 2010): 223–24. https://doi.org/10.1111/j.1540-8191.2009.00956.x.
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    • Andersen, Nicholas D., John Dubose, Ankoor Shah, Teng Lee, Stephanie B. Wechsler, and G Chad Hughes. “Thoracic endografting in a patient with hereditary hemorrhagic telangiectasia presenting with a descending thoracic aneurysm.” J Vasc Surg 51, no. 2 (February 2010): 468–70. https://doi.org/10.1016/j.jvs.2009.08.058.
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    • Parsa, Cyrus J., Mani A. Daneshmand, Brian Lima, Keki Balsara, Richard L. McCann, and G Chad Hughes. “Utility of remote wireless pressure sensing for endovascular leak detection after endovascular thoracic aneurysm repair.” Ann Thorac Surg 89, no. 2 (February 2010): 446–52. https://doi.org/10.1016/j.athoracsur.2009.10.068.
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    • Parsa, Cyrus J., Jacob N. Schroder, Mani A. Daneshmand, Richard L. McCann, and G Chad Hughes. “Midterm results for endovascular repair of complicated acute and chronic type B aortic dissection.” Ann Thorac Surg 89, no. 1 (January 2010): 97–102. https://doi.org/10.1016/j.athoracsur.2009.09.029.
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    • Hughes, G Chad, Mani A. Daneshmand, Keki R. Balsara, Hardean A. Achneck, Bantayehu Sileshi, Sean M. Lee, and Richard L. McCann. “"Hybrid" repair of aneurysms of the transverse aortic arch: midterm results.” Ann Thorac Surg 88, no. 6 (December 2009): 1882–87. https://doi.org/10.1016/j.athoracsur.2009.07.027.
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    • Rajagopal, Keshava, Joseph G. Rogers, Andrew J. Lodge, Jeffrey G. Gaca, Richard L. McCann, Carmelo A. Milano, and G Chad Hughes. “Two-stage total cardioaortic replacement for end-stage heart and aortic disease in Marfan syndrome: case report and review of the literature.” J Heart Lung Transplant 28, no. 9 (September 2009): 958–63. https://doi.org/10.1016/j.healun.2009.05.012.
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    • Atkins, Broadus Zane, Mary Kay Wooten, Jean Kistler, Kista Hurley, G Chad Hughes, and Walter G. Wolfe. “Does negative pressure wound therapy have a role in preventing poststernotomy wound complications?” Surg Innov 16, no. 2 (June 2009): 140–46. https://doi.org/10.1177/1553350609334821.
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    • Parsa, Cyrus J., Carmelo A. Milano, Alan D. Proia, G Burkhard Mackensen, and G Chad Hughes. “A previously unreported complication of apicoaortic conduit for severe aortic stenosis.” Ann Thorac Surg 87, no. 3 (March 2009): 927–28. https://doi.org/10.1016/j.athoracsur.2008.07.061.
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    • Hughes, G Chad, and Richard L. McCann. “Hybrid thoracoabdominal aortic aneurysm repair: concomitant visceral revascularization and endovascular aneurysm exclusion.” Semin Thorac Cardiovasc Surg 21, no. 4 (2009): 355–62. https://doi.org/10.1053/j.semtcvs.2009.11.010.
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    • Parsa, Cyrus J., and G Chad Hughes. “Surgical options to contend with thoracic aortic pathology.” Semin Roentgenol 44, no. 1 (January 2009): 29–51. https://doi.org/10.1053/j.ro.2008.10.004.
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    • Swaminathan, M., M. Stuart, G. C. Hughes, J. Jaggers, S. E. Hill, C. A. Milano, E. Bennett-Guerrero, and M. Stafford-Smith. “Institutional response to FDA warning on aprotinin and impact on outcomes.” Hsr Proc Intensive Care Cardiovasc Anesth 1, no. 1 (2009): 30–36.
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    • Hughes, G Chad, Christopher F. Sulzer, Richard L. McCann, and Madhav Swaminathan. “Endovascular approaches to complex thoracic aortic disease.” Semin Cardiothorac Vasc Anesth 12, no. 4 (December 2008): 298–319. https://doi.org/10.1177/1089253208328667.
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    • Hughes, G Chad, Mani A. Daneshmand, Madhav Swaminathan, Jeffrey J. Nienaber, Errol L. Bush, Aatif H. Husain, Walter G. Wolfe, and Richard L. McCann. “"Real world" thoracic endografting: results with the Gore TAG device 2 years after U.S. FDA approval.” Ann Thorac Surg 86, no. 5 (November 2008): 1530–37. https://doi.org/10.1016/j.athoracsur.2008.07.089.
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    • Mullenix, Philip S., Cyrus J. Parsa, G Burkhard Mackensen, James G. Jollis, J Kevin Harrison, and G Chad Hughes. “Pannus-related prosthetic valve dysfunction and life-threatening aortic regurgitation.” J Heart Valve Dis 17, no. 6 (November 2008): 666–69.
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    • Hughes, G Chad, Jeffrey J. Nienaber, Errol L. Bush, Mani A. Daneshmand, and Richard L. McCann. “Use of custom Dacron branch grafts for "hybrid" aortic debranching during endovascular repair of thoracic and thoracoabdominal aortic aneurysms.” J Thorac Cardiovasc Surg 136, no. 1 (July 2008): 21-28.e6. https://doi.org/10.1016/j.jtcvs.2008.02.051.
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    • Husain, Aatif M., Madhav Swaminathan, Richard L. McCann, and G Chad Hughes. “Neurophysiologic intraoperative monitoring during endovascular stent graft repair of the descending thoracic aorta.” J Clin Neurophysiol 24, no. 4 (August 2007): 328–35. https://doi.org/10.1097/WNP.0b013e31811ebf6e.
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    • Rajagopal, Keshava, Brian Lima, J Kevin Harrison, Madhav Swaminathan, Richard L. McCann, and G Chad Hughes. “Endovascular thoracic aortic aneurysm repair with concomitant myocardial and carotid revascularization.” Ann Thorac Surg 84, no. 1 (July 2007): e1–3. https://doi.org/10.1016/j.athoracsur.2007.03.038.
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    • Swaminathan, Madhav, Georg B. Mackensen, Mihai V. Podgoreanu, Richard L. McCann, Joseph P. Mathew, and George C. Hughes. “Spontaneous echocardiographic contrast indicating successful endoleak management.” Anesth Analg 104, no. 5 (May 2007): 1037–39. https://doi.org/10.1213/01.ane.0000263269.68845.83.
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    • Hughes, G Chad, Madhav Swaminathan, and Walter G. Wolfe. “Reimplantation technique (David operation) for multiple sinus of valsalva aneurysms.” Ann Thorac Surg 82, no. 2 (August 2006): e14–16. https://doi.org/10.1016/j.athoracsur.2006.04.076.
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    • Lima, Brian, G Chad Hughes, Anthony Lemaire, James Jaggers, Donald D. Glower, and Walter G. Wolfe. “Short-term and intermediate-term outcomes of aortic root replacement with St. Jude mechanical conduits and aortic allografts.” Ann Thorac Surg 82, no. 2 (August 2006): 579–85. https://doi.org/10.1016/j.athoracsur.2006.03.068.
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    • Hughes, G Chad, and Brian H. Annex. “Angiogenic therapy for coronary artery and peripheral arterial disease.” Expert Rev Cardiovasc Ther 3, no. 3 (May 2005): 521–35. https://doi.org/10.1586/14779072.3.3.521.
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    • Hughes, G Chad, Shankha S. Biswas, Bangliang Yin, R Edward Coleman, Timothy R. DeGrado, Carolyn K. Landolfo, James E. Lowe, Brian H. Annex, and Kevin P. Landolfo. “Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF.” Ann Thorac Surg 77, no. 3 (March 2004): 812–18. https://doi.org/10.1016/j.athoracsur.2003.09.060.
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    • Biswas, Shankha S., G Chad Hughes, John E. Scarborough, Patrick W. Domkowski, Luis Diodato, Monica L. Smith, Carolyn Landolfo, James E. Lowe, Brian H. Annex, and Kevin P. Landolfo. “Intramyocardial and intracoronary basic fibroblast growth factor in porcine hibernating myocardium: a comparative study.” J Thorac Cardiovasc Surg 127, no. 1 (January 2004): 34–43. https://doi.org/10.1016/j.jtcvs.2003.07.003.
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    • Hughes, G Chad, Dmitri V. Baklanov, Shankha S. Biswas, Anne M. Pippen, Timothy R. DeGrado, R Edward Coleman, Carolyn K. Landolfo, James E. Lowe, Brian H. Annex, and Kevin P. Landolfo. “Regional cardiac sympathetic innervation early and late after transmyocardial laser revascularization.” J Card Surg 19, no. 1 (January 2004): 21–27. https://doi.org/10.1111/j.0886-0440.2004.04005.x.
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    • Hughes, G Chad, Mark J. Post, Michael Simons, and Brian H. Annex. “Translational physiology: porcine models of human coronary artery disease: implications for preclinical trials of therapeutic angiogenesis.” J Appl Physiol (1985) 94, no. 5 (May 2003): 1689–1701. https://doi.org/10.1152/japplphysiol.00465.2002.
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    • Hughes, G Chad, Shankha S. Biswas, Bangliang Yin, Dmitri V. Baklanov, Brian H. Annex, R Edward Coleman, Timothy R. DeGrado, Carolyn K. Landolfo, Kevin P. Landolfo, and James E. Lowe. “A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardium.” J Am Coll Cardiol 39, no. 7 (April 3, 2002): 1220–28. https://doi.org/10.1016/s0735-1097(02)01734-5.
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    • Biswas, S., F. Clements, L. Diodato, G. C. Hughes, and K. Landolfo. “Changes in systolic and diastolic function during multivessel off-pump coronary bypass grafting.” Eur J Cardiothorac Surg 20, no. 5 (November 2001): 913–17. https://doi.org/10.1016/s1010-7940(01)00932-0.
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    • Hughes, G. C., C. K. Landolfo, B. Yin, T. R. DeGrado, R. E. Coleman, K. P. Landolfo, and J. E. Lowe. “Is chronically dysfunctional yet viable myocardium distal to a severe coronary stenosis hypoperfused?” Ann Thorac Surg 72, no. 1 (July 2001): 163–68. https://doi.org/10.1016/s0003-4975(01)02685-6.
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    • Domkowski, P. W., G. C. Hughes, J. E. Scarborough, L. H. Diodato, M. L. Smith, K. P. Landolfo, and J. E. Lowe. “Lasers in cardiothoracic surgery.” Optics and Photonics News 12, no. 7 (January 1, 2001): 36–41. https://doi.org/10.1364/OPN.12.7.000036.
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    • Hughes, G. C., A. P. Kypson, B. H. Annex, B. Yin, J. D. St Louis, S. S. Biswas, R. E. Coleman, et al. “Induction of angiogenesis after TMR: a comparison of holmium: YAG, CO2, and excimer lasers.” Ann Thorac Surg 70, no. 2 (August 2000): 504–9. https://doi.org/10.1016/s0003-4975(00)01569-1.
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    • St Louis, J. D., G. C. Hughes, A. P. Kypson, T. R. DeGrado, C. L. Donovan, R. E. Coleman, B. Yin, C. Steenbergen, K. P. Landolfo, and J. E. Lowe. “An experimental model of chronic myocardial hibernation.” Ann Thorac Surg 69, no. 5 (May 2000): 1351–57. https://doi.org/10.1016/s0003-4975(00)01130-9.
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    • Landolfo, C. K., K. P. Landolfo, G. C. Hughes, E. R. Coleman, R. B. Coleman, and J. E. Lowe. “Intermediate-term clinical outcome following transmyocardial laser revascularization in patients with refractory angina pectoris.” Circulation 100, no. 19 Suppl (November 9, 1999): II128–33. https://doi.org/10.1161/01.cir.100.suppl_2.ii-128.
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    • Lowe, J. E., G. C. Hughes, and S. S. Biswas. “Non-blood-contacting biventricular support: Direct mechanical ventricular actuation.” Operative Techniques in Thoracic and Cardiovascular Surgery 4, no. 4 (November 1, 1999): 345–51. https://doi.org/10.1016/S1522-2942(07)70128-9.
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    • Hughes, G. C., B. H. Annex, B. Yin, A. M. Pippen, P. Lin, A. P. Kypson, K. G. Peters, J. E. Lowe, and K. P. Landolfo. “Transmyocardial laser revascularization limits in vivo adenoviral-mediated gene transfer in porcine myocardium.” Cardiovasc Res 44, no. 1 (October 1999): 81–90. https://doi.org/10.1016/s0008-6363(99)00182-0.
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    • Hughes, G. C., S. Abdel-aleem, S. S. Biswas, K. P. Landolfo, and J. E. Lowe. “Transmyocardial laser revascularization: experimental and clinical results.” Can J Cardiol 15, no. 7 (July 1999): 797–806.
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    • Abdel-Aleem, S., J. D. St Louis, G. C. Hughes, and J. E. Lowe. “Metabolic changes in the normal and hypoxic neonatal myocardium.” Ann N Y Acad Sci 874 (June 30, 1999): 254–61. https://doi.org/10.1111/j.1749-6632.1999.tb09240.x.
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    • Hughes, G. C., A. P. Kypson, J. D. St Louis, B. H. Annex, R. E. Coleman, T. R. DeGrado, C. L. Donovan, J. E. Lowe, and K. P. Landolfo. “Improved perfusion and contractile reserve after transmyocardial laser revascularization in a model of hibernating myocardium.” Ann Thorac Surg 67, no. 6 (June 1999): 1714–20. https://doi.org/10.1016/s0003-4975(99)00317-3.
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    • Hughes, G. C., K. P. Landolfo, J. E. Lowe, R. B. Coleman, and C. L. Donovan. “Diagnosis, incidence, and clinical significance of early postoperative ischemia after transmyocardial laser revascularization.” Am Heart J 137, no. 6 (June 1999): 1163–68. https://doi.org/10.1016/s0002-8703(99)70377-7.
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    • Hughes, G. C., T. L. Ketchersid, J. M. Lenzen, and J. E. Lowe. “Thoracic complications of peritoneal dialysis.” Ann Thorac Surg 67, no. 5 (May 1999): 1518–22. https://doi.org/10.1016/s0003-4975(99)00178-2.
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    • Hughes, G. C., K. P. Landolfo, J. E. Lowe, R. B. Coleman, and C. L. Donovan. “Perioperative morbidity and mortality after transmyocardial laser revascularization: incidence and risk factors for adverse events.” J Am Coll Cardiol 33, no. 4 (March 15, 1999): 1021–26. https://doi.org/10.1016/s0735-1097(98)00676-7.
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    • Hughes, G. C., T. P. Smith, S. R. Eachempati, S. N. Vaslef, and R. L. Reed. “The use of a temporary vena caval interruption device in high-risk trauma patients unable to receive standard venous thromboembolism prophylaxis.” J Trauma 46, no. 2 (February 1999): 246–49. https://doi.org/10.1097/00005373-199902000-00007.
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    • Abdel-aleem, S., N. El-Guindy, T. I. Sallam, G. C. Hughes, and J. E. Lowe. “Stimulation of long-chain fatty acid uptake by dipyridamole in isolated myocytes.” J Cardiovasc Pharmacol 33, no. 1 (January 1999): 43–48. https://doi.org/10.1097/00005344-199901000-00007.
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    • Hughes, G. C., J. E. Lowe, A. P. Kypson, J. D. St Louis, A. M. Pippen, K. G. Peters, R. E. Coleman, et al. “Neovascularization after transmyocardial laser revascularization in a model of chronic ischemia.” Ann Thorac Surg 66, no. 6 (December 1998): 2029–36. https://doi.org/10.1016/s0003-4975(98)01095-9.
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    • Hughes, G. C., C. L. Donovan, J. E. Lowe, and K. P. Landolfo. “Combined TMR and mitral valve replacement via left thoracotomy.” Ann Thorac Surg 65, no. 4 (April 1998): 1141–43. https://doi.org/10.1016/s0003-4975(98)00051-4.
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    • Hasselman, C. T., T. M. Best, C. Hughes, S. Martinez, and W. E. Garrett. “An explanation for various rectus femoris strain injuries using previously undescribed muscle architecture.” Am J Sports Med 23, no. 4 (July 1995): 493–99. https://doi.org/10.1177/036354659502300421.
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    • Hughes, C., C. T. Hasselman, T. M. Best, S. Martinez, and W. E. Garrett. “Incomplete, intrasubstance strain injuries of the rectus femoris muscle.” Am J Sports Med 23, no. 4 (July 1995): 500–506. https://doi.org/10.1177/036354659502300422.
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  • Book Sections

    • Williams, J. B., and G. C. Hughes. “TEVAR Complicated by Acute Retrograde Dissection.” In Current Vascular Surgery. People’s Medical Publishing House, 2013.
    • Lee, T. C., and G. C. Hughes. “Complications of thoracic endovascular stent grafts.” In Cardiothoracic Surgery Review, 581–88, 2012.
    • Stafford-Smith, M., C. Hughes, A. D. Shaw, and M. Swaminathan. “Renal protection strategies.” In Anesthesia and Perioperative Care for Aortic Surgery, 329–47, 2011. https://doi.org/10.1007/978-0-387-85922-4_15.
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    • Hughes, G. C., and J. E. Lowe. “Animal Models of Acute and Chronic Coronary Ischemia: Effects of TMR on Perfusion and Left Ventricular Function.” In Myocardial Laser Revascularization, 65–78, 2007. https://doi.org/10.1002/9780470994832.ch5.
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  • Other Articles

    • Hughes, G Chad. “Invited Commentary.” Ann Thorac Surg, March 2016. https://doi.org/10.1016/j.athoracsur.2015.09.045.
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    • Hughes, G Chad, and Joseph P. Mathew. “Invited Commentary.” Ann Thorac Surg, January 2016. https://doi.org/10.1016/j.athoracsur.2015.07.045.
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    • Englum, Brian R., Asvin M. Ganapathi, and G Chad Hughes. “Reply: To PMID 25301369.” Ann Thorac Surg, October 2015. https://doi.org/10.1016/j.athoracsur.2015.03.091.
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    • Chen, E. P., E. P. Garcia, E. P. Preventza, G. C. Hughes, and H. Patel. “Discussion.” Annals of Thoracic Surgery, August 1, 2015. https://doi.org/10.1016/j.athoracsur.2015.02.095.
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    • Kiefer, Todd L., Sharif Halim, Andrew Wang, J. Kevin Harrison, Jeffrey Gaca, and G Chad Hughes. “Fluoroscopic characterization of surgical bioprosthetic heart valves.” Catheter Cardiovasc Interv, June 2015. https://doi.org/10.1002/ccd.25904.
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    • Andersen, Nicholas D., and G Chad Hughes. “Reply to the editor.” J Thorac Cardiovasc Surg, January 2013. https://doi.org/10.1016/j.jtcvs.2012.09.077.
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    • Andersen, N. D., and G. C. Hughes. “Reply to the editor.” Journal of Thoracic and Cardiovascular Surgery, July 1, 2012. https://doi.org/10.1016/j.jtcvs.2012.03.043.
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    • Hughes, G. C. “Cellular models of hibernating myocardium: implications for future research.” Cardiovasc Res, August 1, 2001. https://doi.org/10.1016/s0008-6363(01)00352-2.
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    • Domkowski, P. W., G. C. Hughes, and J. E. Lowe. “Ameroid constrictor versus hydraulic occluder: creation of hibernating myocardium.” Ann Thorac Surg, June 2000. https://doi.org/10.1016/s0003-4975(00)01476-4.
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    • Beranek, J. T. “Lymphatic angiogenesis induced by transmyocardial laser revascularization.” Ann Thorac Surg, July 1999. https://doi.org/10.1016/s0003-4975(99)00486-5.
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  • Conference Papers

    • Wagner, Matthew A., Hanghang Wang, Ehsan Benrashid, Jeffrey E. Keenan, Yamini Krishnamurthy, Jerrold H. Levy, Ian J. Welsby, and G Chad Hughes. “Protocolized hemostatic factor use in major thoracic aortic surgery.” In J Cardiovasc Surg (Torino), 60:633–36, 2019. https://doi.org/10.23736/S0021-9509.19.10819-1.
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    • Rymer, Jennifer, Katelyn Xiang, Alice Wang, David Cohen, Nimesh Desai, Ajay Jayant Kirtane, G Chad Hughes, J Kevin Harrison, and Sreekanth Vemulapalli. “TCT-7 Predictors and Outcomes of Aborted Procedures During Elective Transcatheter Aortic Valve Replacement.” In Journal of the American College of Cardiology, 72:B3–B3. Elsevier BV, 2018. https://doi.org/10.1016/j.jacc.2018.08.1082.
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    • Cox, Morgan, Muath Bishawi, Uttara Nag, David Ranney, Babatunde Yerokun, Alice Wang, and G Chad Hughes. “IMPACT OF POST-OPERATIVE ATRIAL FIBRILLATION ON EARLY AND LATE OUTCOMES AFTER PROXIMAL AORTIC SURGERY.” In Journal of the American College of Cardiology, 71:A504–A504. Elsevier BV, 2018. https://doi.org/10.1016/s0735-1097(18)31045-3.
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    • Ranney, David N., Morgan L. Cox, Babatunde A. Yerokun, Ehsan Benrashid, Richard L. McCann, and G Chad Hughes. “Long-term results of endovascular repair for descending thoracic aortic aneurysms.” In J Vasc Surg, 67:363–68, 2018. https://doi.org/10.1016/j.jvs.2017.06.094.
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    • Voigt, Soraya L., Muath Bishawi, Richard L. McCann, and G Chad Hughes. “Long-term Outcomes of Carotid-Subclavian Bypass in the Setting of Thoracic Endovascular Aortic Repair.” In Journal of Vascular Surgery, 67:E16–E16. MOSBY-ELSEVIER, 2018.
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    • Wang, Alice, Babatunde Yerokun, Zhuokai Li, Andrzej Kosinski, Morgan L. Cox, Brian C. Gulack, Matthew W. Sherwood, et al. “Fragmented Care Following Transcatheter Aortic Valve Replacement is Associated With Increased 1-year Mortality and Readmission.” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Yerokun, Babatunde A., Jorn Karhausen, David N. Ranney, Ehsan Benrashid, Hanghang Wang, Jeffrey Keenan, Jacob Schroder, Mani Daneshmand, Jeffrey G. Gaca, and G Chad Hughes. “Does Deeper Hypothermia Reduce the Risk of Acute Kidney Injury After Circulatory Arrest for Aortic Arch Surgery?” In Circulation, Vol. 136. LIPPINCOTT WILLIAMS & WILKINS, 2017.
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    • Wang, Hanghang, Matthew Wagner, Ehsan Benrashid, Jeffrey Keenan, Alice Wang, David Ranney, Babatunde Yerokun, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Outcomes of Reoperation After Acute Type A Aortic Dissection: Implications for Index Repair Strategy.” In J Am Heart Assoc, Vol. 6, 2017. https://doi.org/10.1161/JAHA.117.006376.
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    • Fanaroff, Alexander C., Pratik Manandhar, David Holmes, David Cohen, J Kevin Harrison, G Chad Hughes, Vinod Thourani, Michael Mack, William Jones, and Sreekanth Vemulapalli. “PERIPHERAL ARTERY DISEASE AND TRANSCATHETER AORTIC VALVE REPLACEMENT OUTCOMES: A REPORT FROM THE STS/TVT REGISTRY.” In Journal of the American College of Cardiology, 69:991–991. ELSEVIER SCIENCE INC, 2017.
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    • Kochar, Ajar, Zhuokai Li, John Harrison, G Chad Hughes, Vinod Thourani, Michael Mack, David Cohen, Eric Peterson, William Jones, and Sreekanth Vemulapalli. “STROKE AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH CAROTID DISEASE UNDERGOING TAVR: INSIGHTS FROM THE STS/TVT REGISTRY.” In Journal of the American College of Cardiology, 69:1302–1302. ELSEVIER SCIENCE INC, 2017.
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    • Ranney, David, Ehsan Benrashid, Babatunde Yerokun, Hanghang Wang, John Harrison, Andrew Wang, Todd Kiefer, and G Chad Hughes. “SURGERY FOR PATIENTS WITH BICUSPID AORTOPATHY: VALIDATION OF THE 2016 ACC/AHA GUIDELINES CLARIFICATION.” In Journal of the American College of Cardiology, 69:1925–1925. ELSEVIER SCIENCE INC, 2017.
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    • Vora, Amit, Dadi David Dai, Roland Matsouaka, J Kevin Harrison, G Chad Hughes, Matthew Sherwood, Jonathan Piccini, et al. “NEW-ONSET ATRIAL FIBRILLATION FOLLOWING TRANSCATHETER AORTIC VALVE REPLACEMENT: INCIDENCE, ANTICOAGULANT STRATEGY, AND OUTCOMES.” In Journal of the American College of Cardiology, 69:961–961. ELSEVIER SCIENCE INC, 2017.
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    • Wang, Alice, Hanghang Wang, Ehsan Benrashid, David Ranney, Babatunde Yerokun, Matthew W. Sherwood, Jeffrey Gaca, et al. “PREDICTORS OF MORTALITY AFTER TAVR IN A "REAL WORLD" SETTING.” In Journal of the American College of Cardiology, 69:1342–1342. ELSEVIER SCIENCE INC, 2017.
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    • Hughes, C. G. “The development and evolution of an in-situ remote temperature sensing system for advanced composites manufacturing and Repa I R.” In International Sampe Technical Conference, 2013–27, 2017.
    • Rose, J. D., and C. Hughes. “The verification of applicability of the use of embedded microwire temperature sensors in repair scenarios.” In Camx 2017  Composites and Advanced Materials Expo, Vol. 2017-December, 2017.
    • Yerokun, Babatunde A., Muath Bishawi, Adam R. Williams, David N. Ranney, Ehsan Benrashid, Richard L. McCann, and G Chad Hughes. “Impact of Early versus Late Timing of TEVAR on Aortic Remodeling and Long-Term Survival Following Type B Aortic Dissection.” In Journal of Vascular Surgery, 65:e3–4. Elsevier BV, 2017. https://doi.org/10.1016/j.jvs.2016.10.017.
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    • Benrashid, Ehsan, Hanghang Wang, Nicholas D. Andersen, Jeffrey E. Keenan, Richard L. McCann, and George C. Hughes. “An Integrated Approach to Thoracoabdominal Aortic Aneurysm Repair: Complimentary Roles of Open and Hybrid Approaches.” In Journal of Vascular Surgery, 63:287–88. Elsevier BV, 2016. https://doi.org/10.1016/j.jvs.2015.10.035.
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    • Cheruku, Sreekanth, Miklos D. Kertai, Wenjing Qi, Yi-Ju Li, G. C. Hughes, Joseph P. Mathew, and Joern Karhausen. “Mast Cell Activation During Aortic Repair Requiring Circulatory Arrest is Associated With Hemodynamic Instability and Indications of End-Organ Injury.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Sherwood, Matthew W., Sreekanth Vemulapalli, Amit N. Vora, David D. Dai, Sharif Halim, Todd L. Kiefer, G Charles Hughes, J Kevin Harrison, and Eric D. Peterson. “National Variation in Post-tavr Antithrombotic Therapy Utilization in Patients With Atrial Fibrillation: Insights From the Sts/acc Tvt Registry (R).” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Vora, Amit N., John K. Harrison, Allison Dunning, Phillip Schulte, Matthew W. Sherwood, Joseph Kisslo, G. C. Hughes, Fawaz A. Alenezi, Eric Velazquez, and Zainab Samad. “TAVR Versus Medical Management Among Patients With Severe Aortic Stenosis and Left Ventricular Systolic Dysfunction.” In Circulation, Vol. 132. LIPPINCOTT WILLIAMS & WILKINS, 2015.
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    • Harrison, J Kevin, G. C. Hughes, Michael J. Reardon, Robert Stoler, Paul Grayburn, Robert F. Hebeler, and Jeffrey Popma. “TCT-94 Balloon Post-Dilation of the Self-Expanding CoreValve Transcatheter Aortic Valve Bioprosthesis: Procedural Results and In Hospital Outcomes from 3532 patients in the CoreValve US Pivotal and Continued Access Trials.” In Journal of the American College of Cardiology, 66:B43–44. Elsevier BV, 2015. https://doi.org/10.1016/j.jacc.2015.08.139.
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    • Sherwood, Matthew W., Amit N. Vora, Sreekanth Vemulapalli, David Dai, Sharif Halim, Todd Kiefer, G. C. Hughes, and J Kevin Harrison. “TCT-103 National variation in post-TAVR antithrombotic therapy utilization and associated outcomes: Insights from the STS/ACC TVT Registry®.” In Journal of the American College of Cardiology, 66:B47–48. Elsevier BV, 2015. https://doi.org/10.1016/j.jacc.2015.08.149.
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    • Benrashid, Ehsan, Hanghang Wang, Jeffrey E. Keenan, Nicholas D. Andersen, James M. Meza, Richard L. McCann, and G Chad Hughes. “SS7. Hybrid Repair of the Aortic Arch: Long-Term Outcomes After a Decade of Intervention.” In Journal of Vascular Surgery, 61:44S-44S. Elsevier BV, 2015. https://doi.org/10.1016/j.jvs.2015.04.077.
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    • Schechter, Matthew A., Asvin M. Ganapathi, Brian R. Englum, Jeffrey E. Keenan, Hanghang Wang, G Chad Hughes, and Richard L. McCann. “PC46. Improved Long-Term Survival of EVAR Compared to Open Repair.” In Journal of Vascular Surgery, 61:130S-130S. Elsevier BV, 2015. https://doi.org/10.1016/j.jvs.2015.04.247.
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    • Ganapathi, Asvin M., Brian R. Englum, Matthew A. Schechter, John P. Vavalle, J Kevin Harrison, Richard L. McCann, and G Chad Hughes. “Role of cardiac evaluation before thoracic endovascular aortic repair.” In J Vasc Surg, 60:1196–1203, 2014. https://doi.org/10.1016/j.jvs.2014.05.029.
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    • Ganapathi, Asvin, Mark Peterson, Mark E. Lindsay, Himanshu Patel, Reed Pyeritz, Santi Trimarchi, Stuart Hutchison, et al. “TYPE A AORTIC DISSECTION AT A DIAMETER <5.5 CENTIMETERS: DOES MODERATE ENLARGEMENT OF THE AORTIC ROOT CARRY GREATER RISK THAN MODERATE SUPRACORONARY ASCENDING AORTIC ENLARGEMENT?” In Journal of the American College of Cardiology, 63:A2065–A2065. Elsevier BV, 2014. https://doi.org/10.1016/s0735-1097(14)62068-4.
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    • Watson, Kelly A., Asvin M. Ganapathi, Matthew A. Schechter, Brian R. Englum, Richard L. McCann, and G. Chad Hughes. “Repair of Mycotic Thoracoabdominal Aortic Aneurysm Following BCG Treatment.” In Journal of Vascular Surgery, 58:1733–1733. Elsevier BV, 2013. https://doi.org/10.1016/j.jvs.2013.10.022.
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    • Di Eusanio, Marco, Santi Trimarchi, Mark D. Peterson, Truls Myrmel, G. C. Hughes, Amit Korach, Thoralf M. Sundt, et al. “Root Replacement versus More Conservative Management During Type A Acute Aortic Dissection Repair: Insights From the International Registry of Acute Aortic Dissection.” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Vavalle, John P., Patricia Cowper, James A. Nelson, Lvnne Hurwitz, G Chad Hughes, Andrew Wang, Jeffrey G. Gaca, et al. “Inpatient and Outpatient Resource Utilization in the Evaluation and Management of Patients With Aortic Stenosis Being Considered for Transcatheter Aortic Valve Replacement (TAVR).” In Circulation, Vol. 128. LIPPINCOTT WILLIAMS & WILKINS, 2013.
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    • Schechter, Matthew A., Asvin M. Ganapathi, Brian R. Englum, Jennifer M. Hanna, Richard McCann, and G Chad Hughes. “Frailty Does Not Increase Risk in Thoracic Endovascular Aortic Repair.” In Journal of Vascular Surgery, 57:41S-41S. Elsevier BV, 2013. https://doi.org/10.1016/j.jvs.2013.02.165.
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    • Hanna, Jennifer M., Rossella Fattori, Dan Gilon, Gilbert Upchurch, Kevin Harris, Eduardo Bossone, Matthias Voehringer, et al. “PREDICTORS OF IN-HOSPITAL SURVIVAL WITH MEDICAL MANAGEMENT FOR TYPE A ACUTE AORTIC DISSECTION: IMPLICATIONS FOR SUBOPTIMAL SURGICAL CANDIDATES.” In Journal of the American College of Cardiology, 61:E1555–E1555. Elsevier BV, 2013. https://doi.org/10.1016/s0735-1097(13)61555-7.
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    • Hanna, Jennifer M., Asvin Ganapathi, Nicholas Andersen, Richard L. McCann, and G Chad Hughes. “Long-Term Results for Endovascular Repair of Acute Complicated Type B Aortic Dissection.” In Journal of Vascular Surgery, 56:1827–28. Elsevier BV, 2012. https://doi.org/10.1016/j.jvs.2012.10.050.
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    • Vavalle, John P., Harry Phillips, Sara Holleran, Andrew Wang, Christoper M. O’Connor, Peter K. Smith, G Chad Hughes, J Kevin Harrison, and Manesh R. Patel. “Access to Care: Geographical Variations in the Diagnosis and Treatment of Aortic Stenosis in North Carolina.” In Circulation, Vol. 126. LIPPINCOTT WILLIAMS & WILKINS, 2012.
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    • Andersen, Nicholas D., Jennifer M. Hanna, Syamal D. Bhattacharya, Judson B. Williams, Jeffrey G. Gaca, Richard L. McCann, and G Chad Hughes. “Insurance status predicts non-elective case status but not outcomes of thoracic aortic operations.” In Journal of the American College of Surgeons, 215:S45–46. Elsevier BV, 2012. https://doi.org/10.1016/j.jamcollsurg.2012.06.136.
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    • Hanna, Jennifer M., Nicholas D. Andersen, Asad A. Shah, J Kevin Harrison, Richard L. McCann, and G Chad Hughes. “Open femoral access for transcatheter aortic intervention leads to fewer major vascular complications.” In Journal of the American College of Surgeons, 215:S42–S42. Elsevier BV, 2012. https://doi.org/10.1016/j.jamcollsurg.2012.06.128.
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    • Bossone, E., A. Korach, R. Fattori, G. C. Hughes, T. T. Tsai, D. G. Montgomery, K. A. Eagle, C. A. Nienaber, E. M. Isselbacher, and T. Suzuki. “Racial differences in acute aortic dissection: insights from the International Registry of Acute Aortic Dissection.” In European Heart Journal, 33:82–83. OXFORD UNIV PRESS, 2012.
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    • Shah, Asad A., Damian M. Craig, Judson B. Williams, Syamal D. Bhattacharya, Nicholas D. Andersen, Svati H. Shah, Richard L. McCann, and G Chad Hughes. “PS24. Risk Factors for Non-Procedure Related Mortality One Year after Thoracic Endovascular Aortic Repair.” In Journal of Vascular Surgery, 53:36S-36S. Elsevier BV, 2011. https://doi.org/10.1016/j.jvs.2011.03.077.
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    • Williams, Judson B., Jonathan P. Piccini, Syamal D. Bhattacharya, Nicholas D. Andersen, Richard L. McCann, and G Chad Hughes. “PS28. Retrograde Ascending Aortic Dissection as an Early Complication of Thoracic Endovascular Aortic Repair.” In Journal of Vascular Surgery, 53:37S-37S. Elsevier BV, 2011. https://doi.org/10.1016/j.jvs.2011.03.079.
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    • Shah, A. A., J. B. Williams, B. Phillips-Bute, R. Bartz, G. C. Hughes, and I. J. Welsby. “Pulmonary Dysfunction After Thoracic Aortic Surgery Utilizing Deep Hypothermic Circulatory Arrest.” In American Journal of Respiratory and Critical Care Medicine, Vol. 183. AMER THORACIC SOC, 2011.
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    • Hughes, G Chad, Yue Zhao, J Scott Rankin, Sean O’Brien, Joseph E. Bavaria, Walter G. Wolfe, Jeffrey G. Gaca, James S. Gammie, David M. Shahian, and Peter K. Smith. “Effects of Institutional Volumes on Operative Outcomes for Combined Aortic Valve and Ascending Aortic Surgery.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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    • Mehta, Rajendra H., Emily Honeycutt, G Chad Hughes, and Michael H. Sketch. “Relationship of Time Interval Between Elective Coronary Artery Bypass Surgery and Cardiac Catheterization With the Risk of Post-Surgical Acute Kidney Injury.” In Circulation, Vol. 122. LIPPINCOTT WILLIAMS & WILKINS, 2010.
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    • Patel, Mayur B., Syamal D. Bhattacharya, Judson B. Williams, Timothy E. Sweeney, Steven N. Vaslef, G Chad Hughes, Paul C. Kuo, and Jeffery H. Lawson. “Six Year, Single Institution, off-Label Use of Recombinant Factor VIIa.” In Blood, 116:603–603. AMER SOC HEMATOLOGY, 2010.
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    • Ibrahim, I. A., A. Hassan, Z. Abdel-Wahab, A. El-ghanam, G. C. Hughes, R. Thomas, D. Taylor, J. E. Lowe, and S. Abel-aleem. “Depression of cytosolic heart fatty acid binding protein (H-FABP) expression in adriamycin-induced cardiomyopathy and its reversal by L-carnitine.” In Faseb Journal, 13:A907–A907. FEDERATION AMER SOC EXP BIOL, 1999.
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    • Abdel-aleem, S., A. M. Kishk, A. G. Hassan, G. C. Hughes, I. A. Ibrahim, D. A. Taylor, and J. E. Lowe. “The enhancement of insulin-sensitive glucose transporter expression by chronic inhibition of fatty acid oxidation in the diabetic rat heart.” In Circulation, 98:213–213. LIPPINCOTT WILLIAMS & WILKINS, 1998.
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    • Hughes, G. “Perioperative Morbidity and Mortality Following Transmyocardial Laser Revascularization.” In Journal of the American College of Cardiology, 31:285A-286A. Elsevier BV, 1998. https://doi.org/10.1016/s0735-1097(97)84951-0.
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    • St. Louis, J. “An Experimental Model of Myocardial Hibernation.” In Journal of the American College of Cardiology, 31:409A-409A. Elsevier BV, 1998. https://doi.org/10.1016/s0735-1097(97)85477-0.
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