George Charles Hughes IV

Professor of Surgery

Surgery, Cardiovascular and Thoracic Surgery

Box 3051 Med Ctr, Durham, NC 27710

3580 White Zone, Duke South, Durham, NC 27710

AT A GLANCE

Credentials
1. Education

Academic Experience
1. Current Appointments & Affiliations
2. Previous Appointments & Affiliations

Expertise

Research
1. Selected Grants

Publications
1. Selected Publications

Artistic Works / Events

Teaching

Advising & Mentoring

Recognition

Professional Activities

Selected Grants

EXTEND Thoraflex Hybrid Study

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2023 - 2038

Safety and Performance of Aortic Valve Repair Using the HAART Aortic Annuloplasty Devices

Clinical TrialPrincipal Investigator · Awarded by BioStable Science & Engineering, Inc. · 2020 - 2036

Corcym Inc - MANTRA Study - Pro00110315

Clinical TrialPrincipal Investigator · Awarded by Corcym, Inc · 2022 - 2032

A Multi-arm, Multi-Center, Non-Randomized, Prospective, Clinical Study to Evaluate the Safety and Effectiveness of the NEXUSTM Aortic Arch Stent Graft System in Treating Thoracic Aortic Lesions Involving the Aortic Arch

Clinical TrialPrincipal Investigator · Awarded by Endospan, Ltd · 2021 - 2031

A Prospective and Retrospective, Multi-Centre, Post-Market, NonInterventional Study of Terumo Aortic* Cardiovascular Patches, and Knitted and Woven Grafts

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2021 - 2031

EXTEND Thoraflex Hybrid Study

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2023 - 2038

Safety and Performance of Aortic Valve Repair Using the HAART Aortic Annuloplasty Devices

Clinical TrialPrincipal Investigator · Awarded by BioStable Science & Engineering, Inc. · 2020 - 2036

Corcym Inc - MANTRA Study - Pro00110315

Clinical TrialPrincipal Investigator · Awarded by Corcym, Inc · 2022 - 2032

A Multi-arm, Multi-Center, Non-Randomized, Prospective, Clinical Study to Evaluate the Safety and Effectiveness of the NEXUSTM Aortic Arch Stent Graft System in Treating Thoracic Aortic Lesions Involving the Aortic Arch

Clinical TrialPrincipal Investigator · Awarded by Endospan, Ltd · 2021 - 2031

A Prospective and Retrospective, Multi-Centre, Post-Market, NonInterventional Study of Terumo Aortic* Cardiovascular Patches, and Knitted and Woven Grafts

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2021 - 2031

TITAN

Clinical TrialPrincipal Investigator · Awarded by Ottawa Heart Research Institute · 2022 - 2027

GORE - TAMBE AAA 17-01

Clinical TrialPrincipal Investigator · Awarded by W. L. Gore & Associates, Inc. · 2020 - 2026

Placement of AoRTic TraNscathetER Valves Trial II (PARTNER II) Sapien 3 Intermediate (PIIS3i)

Clinical TrialCo-Principal Investigator · Awarded by Edwards Lifesciences Corporation · 2014 - 2025

CryoLife PROACT

Clinical TrialPrincipal Investigator · Awarded by Artivion, Inc · 2020 - 2025

A Prospective, Multicenter, Non-Blinded, Non-Randomized Early Feasibility Study of the RelayBranch Thoracic Stent-Graft System in Subjects with Thoracic Aortic Pathologies Requiring Treatment Proximal to the Origin of the Innominate Artery

Clinical TrialPrincipal Investigator · Awarded by Bolton Medical, Inc. · 2019 - 2025

A Prospective, Multicenter, Non-Blinded, Non-Randomized Study of the RelayPro Thoracic Stent-Graft in Subjects with Thoracic Aortic Aneurysms and Penetrating Atherosclerotic Ulcers

Clinical TrialPrincipal Investigator · Awarded by Bolton Medical, Inc. · 2019 - 2025

Evaluation of the GORE® TAG® Thoracic Branch Endoprosthesis (TBE Device) in the Treatment of Lesions of the Aortic Arch and Descending Thoracic Aorta

Clinical TrialPrincipal Investigator · Awarded by W. L. Gore & Associates, Inc. · 2017 - 2024

TAVR in Low Risk Patients

Clinical TrialCo Investigator · Awarded by Medtronic, Inc. · 2016 - 2024

Using Computational Fluid Dynamics to Predict Aneurysmal Degeneration of the Distal Aorta After Repair of Type A Dissection

FellowshipMentor · Awarded by American Heart Association · 2022 - 2023

Valiant EVO US Clinical Trial

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2016 - 2023

Post-Approval Study of the Relay Thoracic Stent-Graft with Plus Delivery System in Patients with Thoracic Aortic Aneurysms and Penetrating Ulcers

Clinical TrialPrincipal Investigator · Awarded by Bolton Medical, Inc. · 2014 - 2023

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2016 - 2023

Sure-AVR

ResearchPrincipal Investigator · Awarded by LivaNova · 2019 - 2022

Mitrofolow Aortic Pericardial Heart Valve with Phospholipid Reduction Treatment

Clinical TrialPrincipal Investigator · Awarded by Sorin Group · 2015 - 2021

Metabolomic and microRNA signatures in peripheral blood of patients with thoracic aortic aneurysm

FellowshipPrincipal Investigator · Awarded by Thoracic Surgery Foundation for Research and Education · 2015 - 2017

Evaluation of the Thoraflex Hybrid Device for Use in Repair or Replacement of the Ascending Aorta, Aortic Arch, and Descending Aorta in an Open Surgical Procedure

Clinical TrialPrincipal Investigator · Awarded by Terumo Medical Corporation · 2016 - 2017

CardioCel Tri-leaflet Repair Study

Clinical TrialPrincipal Investigator · Awarded by Admedus Limited · 2016 - 2016

A Retrospective Chart Review Study to Investigate Bleeding Risk and Blood Transfusion Requirements in Patients Undergoing Complex Cardiovascular Surgery in the United States

ResearchPrincipal Investigator · Awarded by CSL Behring LLC · 2014 - 2015

A Phase II, Randomized, Placebo-Controlled, Double-Blind (Sponsor Open) Study of GSK1278863, a HIF-Prolyl Hydroxylase Inhibitor, to Reduce Ischemic Events in Patients Undergoing Thoracic Aortic Aneurysm Repair

Clinical TrialPrincipal Investigator · Awarded by GlaxoSmithKline · 2013 - 2015

Transmyocardial Laser Revascularization: Mechanisms . . .

ResearchPI-Fellow · Awarded by National Institutes of Health · 1998 - 2000