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George Charles Hughes IV

Professor of Surgery
Surgery, Cardiovascular and Thoracic Surgery
Box 3051 Med Ctr, Durham, NC 27710
3580 White Zone, Duke South, Durham, NC 27710

Selected Grants


EXTEND Thoraflex Hybrid Study

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2023 - 2038

Safety and Performance of Aortic Valve Repair Using the HAART Aortic Annuloplasty Devices

Clinical TrialPrincipal Investigator · Awarded by BioStable Science & Engineering, Inc. · 2020 - 2036

Corcym Inc - MANTRA Study - Pro00110315

Clinical TrialPrincipal Investigator · Awarded by Corcym, Inc · 2022 - 2032

EXTEND Thoraflex Hybrid Study

Clinical TrialPrincipal Investigator · Awarded by Vascutek Limited · 2023 - 2038

Safety and Performance of Aortic Valve Repair Using the HAART Aortic Annuloplasty Devices

Clinical TrialPrincipal Investigator · Awarded by BioStable Science & Engineering, Inc. · 2020 - 2036

Corcym Inc - MANTRA Study - Pro00110315

Clinical TrialPrincipal Investigator · Awarded by Corcym, Inc · 2022 - 2032

TITAN

Clinical TrialPrincipal Investigator · Awarded by Ottawa Heart Research Institute · 2022 - 2027

GORE - TAMBE AAA 17-01

Clinical TrialPrincipal Investigator · Awarded by W. L. Gore & Associates, Inc. · 2020 - 2026

Placement of AoRTic TraNscathetER Valves Trial II (PARTNER II) Sapien 3 Intermediate (PIIS3i)

Clinical TrialCo-Principal Investigator · Awarded by Edwards Lifesciences Corporation · 2014 - 2025

CryoLife PROACT

Clinical TrialPrincipal Investigator · Awarded by Artivion, Inc · 2020 - 2025

TAVR in Low Risk Patients

Clinical TrialCo Investigator · Awarded by Medtronic, Inc. · 2016 - 2024

Valiant EVO US Clinical Trial

Clinical TrialPrincipal Investigator · Awarded by Medtronic, Inc. · 2016 - 2023

Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2016 - 2023

Sure-AVR

ResearchPrincipal Investigator · Awarded by LivaNova · 2019 - 2022

Mitrofolow Aortic Pericardial Heart Valve with Phospholipid Reduction Treatment

Clinical TrialPrincipal Investigator · Awarded by Sorin Group · 2015 - 2021

Metabolomic and microRNA signatures in peripheral blood of patients with thoracic aortic aneurysm

FellowshipPrincipal Investigator · Awarded by Thoracic Surgery Foundation for Research and Education · 2015 - 2017

CardioCel Tri-leaflet Repair Study

Clinical TrialPrincipal Investigator · Awarded by Admedus Limited · 2016 - 2016

Transmyocardial Laser Revascularization: Mechanisms . . .

ResearchPI-Fellow · Awarded by National Institutes of Health · 1998 - 2000

External Relationships


  • W. L. Gore & Associates, Inc.

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.