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Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.

Publication ,  Journal Article
Lv, Y-B; Yin, Z-X; Chei, C-L; Qian, H-Z; Kraus, VB; Zhang, J; Brasher, MS; Shi, X-M; Matchar, DB; Zeng, Y
Published in: Atherosclerosis
March 2015

OBJECTIVE: Low-density lipoprotein cholesterol (LDL-C) is a risk factor for survival in middle-aged individuals, but conflicting evidence exists on the relationship between LDL-C and all-cause mortality among the elderly. The goal of this study was to assess the relationship between LDL-C and all-cause mortality among Chinese oldest old (aged 80 and older) in a prospective cohort study. METHODS: LDL-C concentration was measured at baseline and all-cause mortality was calculated over a 3-year period. Multiple statistical models were used to adjust for demographic and biological covariates. RESULTS: During three years of follow-up, 447 of 935 participants died, and the overall all-cause mortality was 49.8%. Each 1 mmol/L increase of LDL-C concentration corresponded to a 19% decrease in 3-year all-cause mortality (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.71-0.92). The crude HR for abnormally higher LDL-C concentration (≥3.37 mmol/L) was 0.65 (0.41-1.03); and the adjusted HR was statistically significant around 0.60 (0.37-0.95) when adjusted for different sets of confounding factors. Results of sensitivity analysis also showed a significant association between higher LDL-C and lower mortality risk. CONCLUSIONS: Among the Chinese oldest old, higher LDL-C level was associated with lower risk of all-cause mortality. Our findings suggested the necessity of re-evaluating the optimal level of LDL-C among the oldest old.

Duke Scholars

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

March 2015

Volume

239

Issue

1

Start / End Page

137 / 142

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Risk Factors
  • Prospective Studies
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Follow-Up Studies
 

Citation

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Lv, Y.-B., Yin, Z.-X., Chei, C.-L., Qian, H.-Z., Kraus, V. B., Zhang, J., … Zeng, Y. (2015). Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey. Atherosclerosis, 239(1), 137–142. https://doi.org/10.1016/j.atherosclerosis.2015.01.002
Lv, Yue-Bin, Zhao-Xue Yin, Choy-Lye Chei, Han-Zhu Qian, Virginia Byers Kraus, Juan Zhang, Melanie Sereny Brasher, Xiao-Ming Shi, David Bruce Matchar, and Yi Zeng. “Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.Atherosclerosis 239, no. 1 (March 2015): 137–42. https://doi.org/10.1016/j.atherosclerosis.2015.01.002.
Lv, Yue-Bin, et al. “Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.Atherosclerosis, vol. 239, no. 1, Mar. 2015, pp. 137–42. Pubmed, doi:10.1016/j.atherosclerosis.2015.01.002.
Lv Y-B, Yin Z-X, Chei C-L, Qian H-Z, Kraus VB, Zhang J, Brasher MS, Shi X-M, Matchar DB, Zeng Y. Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey. Atherosclerosis. 2015 Mar;239(1):137–142.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

March 2015

Volume

239

Issue

1

Start / End Page

137 / 142

Location

Ireland

Related Subject Headings

  • Treatment Outcome
  • Sensitivity and Specificity
  • Risk Factors
  • Prospective Studies
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
  • Follow-Up Studies